01378nas a2200301 4500008004100000022001400041245008300055210006900138260000800207300001500215490000700230520045900237653001500696653002400711653001300735653002000748653001200768653001800780653001200798653001600810653001600826653003000842100002200872700002000894700002600914700002500940856011100965 2017 eng d a1477-052000aNickel-catalyzed N-vinylation of heteroaromatic amines via C-H bond activation0 aNickelcatalyzed Nvinylation of heteroaromatic amines via CH bond cSEP a 6896-69000 v153 a

Here, we report a ligand- and reductant-free nickel-catalyzed N-vinylation of heteroaromatic amines using biorenewable p-cymene as a solvent. This unprecedented cross-coupling strategy has high functional group tolerance (halides, alkoxy, cyano, chiral motif, etc.) and proceeded via C-H bond activation.

10aAlkylation10aAmination Reactions10aAnilines10aAryl Chlorides10ahalides10aMonoarylation10aO Bonds10aPrecatalyst10aPyrimidines10aRemoveble Directing Group1 aLandge, Vinod, G.1 aRana, Jagannath1 aSubaramanian, Murugan1 aBalaraman, Ekambaram uhttps://library.ncl.res.in/content/nickel-catalyzed-n-vinylation-heteroaromatic-amines-c-h-bond-activation01537nas a2200361 4500008004100000022001400041245007800055210006900133260000800202300001400210490000700224520045500231653002800686653001300714653001400727653001100741653001300752653002000765653002100785653003900806653002400845653002600869653001200895653001700907653001900924653002300943653002500966100002000991700001801011700001801029700002501047856010301072 2017 eng d a0039-788100aSimple cobalt(II) chloride catalyzed N-alkylation of amines with alcohols0 aSimple cobaltII chloride catalyzed Nalkylation of amines with al cSEP a3957-39610 v493 a

A facile cobalt-catalyzed N-alkylation of amines with alcohols using inexpensive, commercially available CoCl2 center dot 6H(2)O is reported. Employing this readily available cobalt catalyst, a variety of amines with wide functional group tolerance were selectively alkylated under benign conditions.

10a(Hetero)Aromatic Amines10aAlcohols10aAmination10aamines10aAnilines10aAromatic-amines10aCobalt Catalysis10aDehydrogenation Borrowing Hydrogen10aEfficient Catalysts10aHydrogen Autotransfer10aIridium10aN-alkylation10aPincer-complex10aSecondary Alcohols10aSelective Alkylation1 aMidya, Siba, P.1 aMondal, Akash1 aBegum, Ayesha1 aBalaraman, Ekambaram uhttps://library.ncl.res.in/content/simple-cobaltii-chloride-catalyzed-n-alkylation-amines-alcohols