02492nas a2200253   4500008004100000022001400041245012000055210006900175260011000244300001600354490000700370520154000377100001901917700001401936700001801950700002001968700001901988700001802007700002002025700002202045700002402067700002102091856012602112       2012                        eng d  a0959-942800aPorous ZnO nanorod for targeted delivery of doxorubicin: in vitro and in vivo response for therapeutic applications0 aPorous ZnO nanorod for targeted delivery of doxorubicin in vitro  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcDEC  a24145-241540 v223 a<p>Cancer cell specific targeted delivery (TDD) by porous nanocarrier is on a high role. Here in a simple route for the synthesis of porous ZnO nanorods (ZnO) has been demonstrated. ZnO expressed very high surface area of 305.14 m(2) g(-1) (S-BET) and uniformly distributed pores of 5 nm. In continuation ZnO has been fabricated with 3-aminophosphonic acid followed by folic acid to yield folate conjugated porous ZnO nanorod (ZnO-FA). High surface area, uniformly distributed pores on its surface make the nanocarrier suitable for high drug loading (88%) of the anticancer drug doxorubicin (DOX). A pH triggered drug release was observed with minimum release in pathophysical conditions. In vitro efficacy of DOX loaded ZnO-FA (ZnO-FA-DOX) has been evaluated against breast cancer cells MDA-MB-231, which is not possible alone by DOX or ZnO-FA. Targeted scaffold with pendant -NH2 group has been covalently bonded with fluorescent dye (RITC) for cellular uptake and imaging studies in MDA-MB-231 cells; the possible pathway for cancer regression has also been evaluated. Even in vivo acute and intravenous toxicological evaluation on murine model system complemented biocompatibility of ZnO-FA in TDD. All together we have collaged a template free synthesis of porous ZnO nanorod, successful targeting on to cancer cells, high drug loading, pH triggered drug release, in vitro efficacy of ZnO-FA-DOX against MDA-MB-231 cells and in vivo compatibility as well. We envisioned the future prospect of porous ZnO nanostructures in TDD.</p>1 aMitra, Shouvik1 aSubia, B.1 aPatra, Prasun1 aChandra, Sourov1 aDebnath, Nitai1 aDas, Sumistha1 aBanerjee, Rahul1 aKundu, Subhas, C.1 aPramanik, Panchanan1 aGoswami, Arunava  uhttps://library.ncl.res.in/content/porous-zno-nanorod-targeted-delivery-doxorubicin-vitro-and-vivo-response-therapeutic-001311nas a2200205   4500008004100000022001400041245006900055210006900124260011000193300001600303490000600319520055600325100001900881700002000900700001700920700002000937700002400957700002100981856010301002       2012                        eng d  a2046-206900aRapid microwave synthesis of fluorescent hydrophobic carbon dots0 aRapid microwave synthesis of fluorescent hydrophobic carbon dots  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT  a12129-121310 v23 a<p>Fluorescent hydrophobic carbon dots (HCDs) have been fabricated from a poloxamer by a simple microwave assisted process within a few minutes for the first time. Small and distinct spherical HCDs emitted bright blue and green fluorescent light depending upon the excitation wavelength and were dispersed easily in a wide variety of organic solvents. HCDs exhibited excellent water resistant behavior with a contact angle of similar to 122 degrees enforcing good hydrophobic character which will be quite useful in potential surface applications.</p>1 aMitra, Shouvik1 aChandra, Sourov1 aKundu, Tanay1 aBanerjee, Rahul1 aPramanik, Panchanan1 aGoswami, Arunava  uhttps://library.ncl.res.in/content/rapid-microwave-synthesis-fluorescent-hydrophobic-carbon-dots-001862nas a2200265   4500008004100000022001400041245010600055210006900161260007700230300001600307490000700323520092000330653001701250653001601267653001801283653002901301653001701330100001701347700001901364700001801383700002101401700002201422700002001444856013201464       2014                        eng d  a0947-653900aMechanical downsizing of a gadolinium(iii)-based metal-organic framework for anticancer drug delivery0 aMechanical downsizing of a gadoliniumiiibased metalorganic frame  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcAUG  a10514-105180 v203 a<p>A Gd-III-based porous metal-organic framework (MOF), Gd-pDBI, has been synthesized using fluorescent linker pDBI (pDBI=(1,4-bis(5-carboxy-1H-benzimidazole-2-yl)benzene)), resulting in a three-dimensional interpenetrated structure with a one-dimensional open channel (1.9x1.2nm) filled with hydrogen-bonded water assemblies. Gd-pDBI exhibits high thermal stability, porosity, excellent water stability, along with organic-solvent and mild acid and base stability with retention of crystallinity. Gd-pDBI was transformed to the nanoscale regime (ca. 140nm) by mechanical grinding to yield MG-Gd-pDBI with excellent water dispersibility (&gt;90min), maintaining its porosity and crystallinity. In vitro and in vivo studies on MG-Gd-pDBI revealed its low blood toxicity and highest drug loading (12wt%) of anticancer drug doxorubicin in MOFs reported to date with pH-responsive cancer-cell-specific drug release.</p>10aball-milling10adoxorubicin10adrug delivery10ametal-organic frameworks10ananocarriers1 aKundu, Tanay1 aMitra, Shouvik1 aPatra, Prasun1 aGoswami, Arunava1 aDiaz, David, Diaz1 aBanerjee, Rahul  uhttps://library.ncl.res.in/content/mechanical-downsizing-gadoliniumiii-based-metal-organic-framework-anticancer-drug-delivery-001493nas a2200217   4500008004100000245007900041210006900120260000800189300001600197490000700213520077400220100001800994700002401012700001901036700002101055700001501076700002501091700002501116700002001141856011401161       2016                        eng d00aChemically delaminated free-standing ultrathin covalent organic nanosheets0 aChemically delaminated freestanding ultrathin covalent organic n  cDEC  a15604-156080 v553 aCovalent organic nanosheets (CONs) are a new class of porous thin two-dimensional (2D) nanostructures that can be easily designed and functionalized and could be useful for separation applications. Poor dispersion, layer restacking, and difficult postsynthetic modifications are the major hurdles that need to be overcome to fabricate scalable CON thin films. Herein, we present a unique approach for the chemical exfoliation of an anthracene-based covalent organic framework (COF) to N-hexylmaleimide-functionalized CONs, to yield centimeter-sized free-standing thin films through layer-by-layer CON assembly at the air-water interface. The thinlayer fabrication technique presented here is simple, scalable, and does not require any surfactants or stabilizing agents.1 aKhayum, Abdul1 aKandambeth, Sharath1 aMitra, Shouvik1 aNair, Sanoop, B.1 aDas, Anuja1 aNagane, Samadhan, S.1 aMukherjee, Rabibrata1 aBanerjee, Rahul  uhttps://library.ncl.res.in/content/chemically-delaminated-free-standing-ultrathin-covalent-organic-nanosheets01032nas a2200169   4500008004100000245009000041210006900131260000800200300001200208490000700220520043600227100001700663700001900680700002200699700002000721856012100741       2016                        eng d00aGadolinium(III)-based porous luminescent metal-organic frameworks for bimodal imaging0 aGadoliniumIIIbased porous luminescent metalorganic frameworks fo  cAUG  a728-7320 v813 aGd-III-based metal-organic frameworks, Gd-pDBI-1 and Gd-pDBI-2, have been synthesized using the linker pDBI (pDBI=1,4-bis(5-carboxy-1H-benzimidazole-2yl)benzene). They exhibited structural diversity due to subtle change in reaction constituents. Owing to the judicious choice of the fluorescent linker, the materials could be used for bimodal imaging (fluorescent and magnetic resonance) and displayed a modest T1 relaxivity value.1 aKundu, Tanay1 aMitra, Shouvik1 aDiaz, David, Diaz1 aBanerjee, Rahul  uhttps://library.ncl.res.in/content/gadoliniumiii-based-porous-luminescent-metal-organic-frameworks-bimodal-imaging-002011nas a2200289   4500008004100000022001400041245008000055210006900135260007100204300001400275490000800289520102800297100001901325700002401344700002301368700002201391700003001413700002101443700002001464700002501484700002101509700001901530700001501549700002201564700002001586856011501606       2017                        eng d  a0002-786300aSelf-exfoliated guanidinium-based ionic covalent organic nanosheets (iCONs)0 aSelfexfoliated guanidiniumbased ionic covalent organic nanosheet  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAR  a2823-28280 v1383 a<p>Covalent organic nanosheets (CONs) have emerged as functional two-dimensional materials for versatile applications. Although pi-pi stacking between layers, hydrolytic instability, possible restacking prevents their exfoliation on to few thin layered CONs from crystalline porous polymers. We anticipated rational designing of a structure by intrinsic ionic linker could be the solution to produce self-exfoliated CONs without external stimuli. In an attempt to address this issue, we have synthesized three self-exfoliated guanidinium halide based ionic covalent organic nanosheets (iCONs) with antimicrobial property. Self-exfoliation phenomenon has been supported by molecular dynamics (MD) simulation as well. Intrinsic ionic guanidinium unit plays the pivotal role for both self-exfoliation and antibacterial property against both Gram-positive and Gram-negative bacteria. Using such iCONs, we have devised a Mixed matrix membrane which could be useful for antimicrobial coatings with plausible medical benefits.</p>1 aMitra, Shouvik1 aKandambeth, Sharath1 aBiswal, Bishnu, P.1 aKhayum, Abdul, M.1 aChoudhury, Chandan, Kumar1 aMehta, Mihir, R.1 aKaur, Gagandeep1 aBanerjee, Subhrashis1 aPrabhune, Asmita1 aVerma, Sandeep1 aRoy, Sudip1 aKharul, Ulhas, K.1 aBanerjee, Rahul  uhttps://library.ncl.res.in/content/self-exfoliated-guanidinium-based-ionic-covalent-organic-nanosheets-icons-002245nas a2200205   4500008004100000245010700041210006900148260000800217300001400225490000800239520152600247100001901773700002801792700001701820700002401837700001601861700002201877700002001899856012001919       2017                        eng d00aTargeted drug delivery in covalent organic nanosheets (CONs) via sequential postsynthetic modification0 aTargeted drug delivery in covalent organic nanosheets CONs via s  cMAR  a4513-45200 v1393 aCovalent organic nanosheets (CONs) have emerged as a new class of functional two-dimensional (2D) porous organic polymeric materials with a high accessible surface, diverse functionality, and chemical stability. They could become versatile candidates for targeted drug delivery. Despite their many advantages, there are limitations to their use for target specific drug delivery. We anticipated that these drawbacks could be overturned by judicious postsynthetic modification steps to use CONs for targeted drug delivery. The postsynthetic modification would not only produce the desired functionality, it would also help to exfoliate to CONs as well. In order to meet this requirement, we have developed a facile, salt-mediated synthesis of covalent organic frameworks (COFs) in the presence of p-toluenesulfonic acid (PTSA). The COFs were subjected to sequential postsynthetic modifications to yield functionalized targeted CONs for targeted delivery of 5-fluorouracil to breast cancer cells. This postsynthetic modification resulted in simultaneous chemical delamination and functionalization to targeted CONs. Targeted CONs showed sustained release of the drug to the cancer cells through receptor mediated endocytosis, which led to cancer cell death via apoptosis. Considering the easy and facile COF synthesis, functionality based postsynthetic modifications, and chemical delamination to CONs for potential advantageous targeted drug delivery, this process can have a significant impact in biomedical applications.1 aMitra, Shouvik1 aSasmal, Himadri, Sekhar1 aKundu, Tanay1 aKandambeth, Sharath1 aMath, Kavya1 aDiaz, David, Diaz1 aBanerjee, Rahul  uhttps://library.ncl.res.in/content/targeted-drug-delivery-covalent-organic-nanosheets-cons-sequential-postsynthetic