00445nas a2200133 4500008004100000245005900041210005900100260000800159300001200167490000700179100001700186700001700203856009100220 2007 eng d00aAu nanoparticle templated synthesis of pNIPAm nanogels0 aAu nanoparticle templated synthesis of pNIPAm nanogels cJAN a719-7260 v191 aSingh, Neetu1 aLyon, Andrew uhttps://library.ncl.res.in/content/au-nanoparticle-templated-synthesis-pnipam-nanogels00448nas a2200133 4500008004100000245004100041210004100082260004700123300001000170100001700180700002700197700001700224856007300241 2007 eng d00aBioconjugation of soft nanomaterials0 aBioconjugation of soft nanomaterials aHoboken, NJ, USA.bJohn Wiley & Sons, Inc. a61-911 aSingh, Neetu1 aBlackburn, William, H.1 aLyon, Andrew uhttps://library.ncl.res.in/content/bioconjugation-soft-nanomaterials00528nas a2200145 4500008004100000245007900041210006900120260000800189300001400197490000700211100001900218700001700237700001700254856011100271 2007 eng d00aDisplacement-induced switching rates of bioresponsive hydrogel microlenses0 aDisplacementinduced switching rates of bioresponsive hydrogel mi cMAY a2527-25320 v191 aKim, Jongseong1 aSingh, Neetu1 aLyon, Andrew uhttps://library.ncl.res.in/content/displacement-induced-switching-rates-bioresponsive-hydrogel-microlenses00566nas a2200145 4500008004100000245010000041210006900141260000800210300001400218490000600232100001900238700001700257700001700274856012900291 2007 eng d00aInfluence of ancillary binding and nonspecific adsorption on bioresponsive hydrogel microlenses0 aInfluence of ancillary binding and nonspecific adsorption on bio cAPR a1157-11610 v81 aKim, Jongseong1 aSingh, Neetu1 aLyon, Andrew uhttps://library.ncl.res.in/content/influence-ancillary-binding-and-nonspecific-adsorption-bioresponsive-hydrogel-microlenses00502nas a2200133 4500008004100000245008200041210006900123260000800192300001400200490000800214100001700222700001700239856011200256 2008 eng d00aSynthesis of multifunctional nanogels using a protected macromonomer approach0 aSynthesis of multifunctional nanogels using a protected macromon cAUG a1061-10690 v2861 aSingh, Neetu1 aLyon, Andrew uhttps://library.ncl.res.in/content/synthesis-multifunctional-nanogels-using-protected-macromonomer-approach00781nas a2200253 4500008004100000245005900041210005900100260000800159300001400167490000600181100002200187700001700209700001700226700001600243700002100259700002700280700002100307700001600328700002800344700002300372700001900395700002500414856008800439 2009 eng d00aFunctional delivery of siRNA in mice using dendriworms0 aFunctional delivery of siRNA in mice using dendriworms cSEP a2495-25040 v31 aAgrawal, Amit, C.1 aMin, Dal-Hee1 aSingh, Neetu1 aZhu, Haihao1 aBirjiniuk, Alona1 avon Maltzahn, Geoffrey1 aHarris, Todd, J.1 aXing, Deyin1 aWoolfenden, Stephen, D.1 aSharp, Phillip, A.1 aCharest, Alain1 aBhatia, Sangeeta, N. uhttps://library.ncl.res.in/content/functional-delivery-sirna-mice-using-dendriworms00518nas a2200169 4500008004100000245005500041210005400096260000900150300001200159490000700171100001700178700001300195700001700208700002000225700001300245856009000258 2009 eng d00aResponsive assemblies and microgel-based materials0 aResponsive assemblies and microgelbased materials c2009 a865-8740 v381 aLyon, Andrew1 aMeng, Z.1 aSingh, Neetu1 aSorrell, C., D.1 aJohn, A. uhttps://library.ncl.res.in/content/responsive-assemblies-and-microgel-based-materials00660nas a2200193 4500008004100000245007000041210006900111260000800180300001200188490000800200100002400208700002500232700001700257700002600274700002400300700001700324700002300341856010200364 2010 eng d00aChronic inflammatory responses to microgel-based implant coatings0 aChronic inflammatory responses to microgelbased implant coatings cJUL a252-2580 v94A1 aBridges, Amanda, W.1 aWhitmire, Rachel, E.1 aSingh, Neetu1 aTempleman, Kellie, L.1 aBabensee, Julia, E.1 aLyon, Andrew1 aGarcia, Andres, J. uhttps://library.ncl.res.in/content/chronic-inflammatory-responses-microgel-based-implant-coatings00603nas a2200169 4500008004100000245007700041210006900118260000800187300001400195490000800209100001700217700002200234700002600256700002300282700002500305856010300330 2010 eng d00aEffect of nanoparticle conjugation on gene silencing by RNA interference0 aEffect of nanoparticle conjugation on gene silencing by RNA inte cJUN a8241-82430 v1321 aSingh, Neetu1 aAgrawal, Amit, C.1 aLeung, Anthony, K. L.1 aSharp, Phillip, A.1 aBhatia, Sangeeta, N. uhttps://library.ncl.res.in/content/effect-nanoparticle-conjugation-gene-silencing-rna-interference00699nas a2200205 4500008004100000245007700041210006900118260000800187300001600195490000800211100001700219700002400236700001200260700001500272700002300287700002600310700002400336700002500360856010800385 2011 eng d00aBioresponsive mesoporous silica nanoparticles for triggered drug release0 aBioresponsive mesoporous silica nanoparticles for triggered drug cDEC a19582-195850 v1331 aSingh, Neetu1 aKarambelkar, Amrita1 aGu, Luo1 aLin, Kevin1 aMiller, Jordan, S.1 aChen, Christopher, S.1 aSailor, Michael, J.1 aBhatia, Sangeeta, N. uhttps://library.ncl.res.in/content/bioresponsive-mesoporous-silica-nanoparticles-triggered-drug-release00750nas a2200229 4500008004100000245007100041210006900112260000800181300001200189490000700201100002700208700001600235700001900251700001700270700002500287700001800312700002500330700002100355700002400376700002500400856009500425 2011 eng d00aNanoparticles that communicate in vivo to amplify tumour targeting0 aNanoparticles that communicate in vivo to amplify tumour targeti cJUL a545-5520 v101 avon Maltzahn, Geoffrey1 aPark, Ji-Ho1 aLin, Kevin, Y.1 aSingh, Neetu1 aSchwoeppe, Christian1 aMesters, Rolf1 aBerdel, Wolfgang, E.1 aRuoslahti, Erkki1 aSailor, Michael, J.1 aBhatia, Sangeeta, N. uhttps://library.ncl.res.in/content/nanoparticles-communicate-vivo-amplify-tumour-targeting02033nas a2200193 4500008004100000022001400041245008100055210006900136260007100205300001400276490000600290520133200296653001601628653003501644653001501679100002001694700001701714856010801731 2014 eng d a1944-824400aControlling the cell adhesion property of silk films by graft polymerization0 aControlling the cell adhesion property of silk films by graft po a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAPR a5005-50110 v63 a

We report here a graft polymerization method to improve the cell adhesion property of Bombyx mori silk fibroin films. B. mori silk has evolved as a promising material for tissue engineering because of its biocompatibility and biodegradability. However, silk's hydrophobic character makes cell adhesion and proliferation difficult. Also, the lack of sufficient reactive amino acid residues makes biofunctionalization via chemical modification challenging. Our study describes a simple method that provides increased chemical handles for tuning of the surface chemistry of regenerated silk films (SFs), thus allowing manipulation of their bioactivity. By grafting pAAc and pHEMA via plasma etching, we have increased carboxylic acid and hydroxyl groups on silk, respectively. These modifications allowed us to tune the hydrophilicity of SFs and provide functional groups for bioconjugation. Our strategy also allowed us to develop silk-based surface coatings, where spatial control over cell adhesion can be achieved. This control over cell adhesion in a particular region of the SFs is difficult to obtain via existing methods of modifying the silk fibroin instead of the SF surface. Thus, our strategy will be a valuable addition to the toolkit of biofunctionalization for enhancing SFs' tissue engineering applications.

10aBombyx mori10apolymer grafting cell adhesion10asilk films1 aDhyani, Vartika1 aSingh, Neetu uhttps://library.ncl.res.in/content/controlling-cell-adhesion-property-silk-films-graft-polymerization-001688nas a2200265 4500008004100000022001400041245009100055210006900146260007100215300001600286490000600302520077300308653001901081653001401100653002601114653001701140653001701157100002101174700002301195700002101218700002401239700002701263700001701290856011501307 2014 eng d a1944-824400aEnhancing cubosome functionality by coating with a single layer of poly-epsilon-lysine0 aEnhancing cubosome functionality by coating with a single layer  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcOCT a17126-171330 v63 a

We report the preparation and characterization of monoolein cubosomes that can be easily surface modified through adsorption of a single layer of cationic poly-epsilon-lysine. Poly-epsilon-lysine coated cubosomes show remarkable stability in serum solution, are nontoxic and, are readily internalized by HeLa cells. The poly-epsilon-lysine coating provides chemical handles for further bioconjugation of the cubosome surface. We also demonstrate that the initial release rate of a hydrophilic drug, Naproxen sodium, from the cubosomes is retarded with just a single layer of polymer. Interestingly, cubosomes loaded with Naproxen sodium, recently shown to have anticancer properties, cause more apoptosis in HeLa cells when compared to free unencapsulated drug.

10abioconjugation10acubosomes10adrug delivery vehicle10adual loading10atheranostics1 aDeshpande, Sonal1 aVenugopal, Edakkal1 aRamagiri, Shobha1 aBellare, Jayesh, R.1 aKumaraswamy, Guruswamy1 aSingh, Neetu uhttps://library.ncl.res.in/content/enhancing-cubosome-functionality-coating-single-layer-poly-epsilon-lysine-001364nas a2200193 4500008004100000022001400041245012200055210006900177260007100246300001400317490000600331520059200337100001800929700002100947700002400968700003000992700001701022856013101039 2014 eng d a2161-165300aMitigating the cytotoxicity of graphene quantum dots and enhancing their applications in bioimaging and drug delivery0 aMitigating the cytotoxicity of graphene quantum dots and enhanci a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcOCT a1064-10680 v33 a

Despite the promising photophysical properties of fluorescent graphene quantum dots (GQDs), their cellular toxicity needs to be addressed before their full potential could be completely realized in biomedicine. A simple method for mitigating the toxicity of GQDs by embedding them in PEG matrix is reported here. The enhanced biocompatibility of polymer modified, P-GQDs, is attributed to reduced reactive oxygen species generation, as measured by an intracellular ROS assay. We also demonstrate the enhanced loading and efficient intracellular delivery of therapeutics by P-GQDs.

1 aChandra, Anil1 aDeshpande, Sonal1 aShinde, Dhanraj, B.1 aPillai, Vijayamohanan, K.1 aSingh, Neetu uhttps://library.ncl.res.in/content/mitigating-cytotoxicity-graphene-quantum-dots-and-enhancing-their-applications-bioimaging-002168nas a2200241 4500008004100000022001400041245013800055210006900193260007300262300001000335490000700345520125800352653001601610653001701626653002601643653002701669653002901696653002201725100002001747700001701767700001901784856012301803 2015 eng d a1387-700300aConstruction and structural diversity of Cd-MOFs with pyrazole based flexible ligands and positional isomer of naphthalenedisulfonate0 aConstruction and structural diversity of CdMOFs with pyrazole ba aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcNOV a35-400 v613 a

In the present communication, we have reported the construction of a series of Cd(II)-MOFs using conformationally flexible ligand (CFL); 3,3',5,5'-tetramethy1-4,4'-bipyrazolyl (H(2)BPz), flexible bent ligand (FBL); methylenebis-(3,5-dimethylpyrazole) (H(2)MBPz) and positional isomer of naphthalene disulfonic acid salt ligands (1,5-NDS, 2,6-NDS). By using these ligands, four new coordination polymers namely [Cd(H(2)MBPz)(2) center dot 1,5-NDSA](n) (NDS-MOF-1), [Cd(H(2)BPz)center dot 1,5-NDSA](n) (NDS-MOF-2), {[Cd(H(2)MBPz)(2)](2+)center dot 2,6-NDSA(2-)}(n), (NDS-MOF-3) and {[Cd(H(2)BPz)(2)](2+).2,6-NDSA(n)(2-}) (NDS-MOF-4) have been synthesized. The crystal structure analysis revealed that the employment of positional isomeric naphthalene disulfonic acid salts resulted in different architectures ranging from one dimensional chain to two dimensional grid network and further connected into a three dimensional supramolecular structure through intermolecular hydrogen bonds, pi center dot center dot center dot pi and C-H center dot center dot center dot pi interactions. In addition, the photophysical properties and thermal stability studies for all the NDS-M0F5 1-4 were also investigated. (C) 2015 Elsevier B.V. All rights reserved.

10aCadmium(II)10aConformation10acoordination polymers10aNaphthalenedisulfonate10aPhotophysical properties10athermal stability1 aSingh, Udai, P.1 aSingh, Neetu1 aChandra, Suman uhttps://library.ncl.res.in/content/construction-and-structural-diversity-cd-mofs-pyrazole-based-flexible-ligands-and-202259nas a2200277 4500008004100000245015100041210006900192260000800261300001600269490000600285520129900291653001801590653002801608653000801636653002001644653003001664653002401694100002001718700001901738700001801757700002101775700001701796700001701813700002001830856013101850 2025 eng d00aBioinspired synthesis of bridged isochromane fused pyrazoles by a silver catalyzed cascade reaction and its application for antibacterial activity0 aBioinspired synthesis of bridged isochromane fused pyrazoles by  cAUG a4184–41950 v53 a

A stereoselective silver catalyzed one pot vinylogous aldol addition followed by a cascade [4+2] cycloaddition reaction of α-arylidene pyrazolinones to in situ generated isochromenylium ions has been developed, which provides an unprecedented bridged [2.2.2] [3.3.1] pentacyclic [5-6-6-6-6] skeleton consisting of an isochroman, chroman, and a pyrazole unit in one molecule with good to high yields as a single diastereomer. This method offers mild reaction conditions, wide substrate compatibility, excellent scalability and easy derivatization. A DFT study was carried out to clarify the reaction mechanism. It was exciting to observe that the unprecedented bridged isochromans synthesized here have shown excellent selectivity toward Gram-positive and Gram-negative bacteria. We demonstrate that while some structures are broad spectrum antibacterial there are two distinct structures that can be explored for selective activity.

10aAntibacterial10aBridged [2.2.2] [3.3.1]10aROS10aStereoselective10aVinylogous aldol addition10a[4+2] cycloaddition1 aSingh, Bhuvnesh1 aTewari, Shreya1 aKaur, Manleen1 aSharma, Himanshu1 aVanka, Kumar1 aSingh, Neetu1 aSingh, Ravi, P. uhttps://library.ncl.res.in/content/bioinspired-synthesis-bridged-isochromane-fused-pyrazoles-silver-catalyzed-cascade-reaction