01363nas a2200241 4500008004100000022001400041245011400055210006900169260000800238520051600246653002700762653001900789653001900808653001500827653002600842100002700868700002200895700001500917700001800932700002200950700002100972856012800993 2019 eng d a1861-472800aOrtho-oxygenative 1,2-difunctionalization of diarylalkynes under merged gold/organophotoredox relay catalysis0 aOrthooxygenative 12difunctionalization of diarylalkynes under me cOCT3 a

Reported herein is an ortho-oxygenative 1,2-difunctionalization of diarylalkynes under merged gold/organophotoredox catalysis to access highly functionalized 2-(2-hydroxyaryl)-2-alkoxy-1-arylethan-1-ones. Detailed mechanistic studies suggested a relay process, initiating with gold-catalyzed hydroalkoxylation of alkynes, to generate enol-ether followed by a key formal [4+2]-cycloaddition reaction. The successful application of the present methodology was also shown for the synthesis of benzofurans.

10abinary catalyst system10aGold catalysis10aorganocatalyst10aphotoredox10asynthetic methodology1 aSancheti, Shashank, P.1 aAkram, Manjur, O.1 aRoy, Rupam1 aBedi, Vaibhav1 aKundu, Shubhankar1 aPatil, Nitin, T. uhttps://library.ncl.res.in/content/ortho-oxygenative-12-difunctionalization-diarylalkynes-under-merged-goldorganophotoredox