02161nas a2200193   4500008004100000022001400041245013700055210006900192260000800261490000700269520141000276100002701686700002701713700002701740700003101767700002101798700001801819856013001837       2018                        eng d  a1935-273500a Nitrosporeusine analogue ameliorates Chandipura virus induced inflammatory response in CNS via NF kappa b inactivation in microglia0 aNitrosporeusine analogue ameliorates Chandipura virus induced in  cJUL0 v123 aChandipura Virus (CHPV), a negative-stranded RNA virus belonging to the Rhabdoviridae family, has been previously reported to bring neuronal apoptosis by activating several factors leading to neurodegeneration. Following virus infection of the central nervous system, microglia, the ontogenetic and functional equivalents of macrophages in somatic tissues gets activated and starts secreting chemokines, thereby recruiting peripheral leukocytes into the brain parenchyma. In the present study, we have systemically examined the effect of CHPV on microglia and the activation of cellular signalling pathways leading to chemokine expression upon CHPV infection. Protein and mRNA expression profiles of chemokine genes revealed that CHPV infection strongly induces the expression of CXC chemokine ligand 10 (CXCL10) and CC chemokine ligand 5 (CCL5) in microglia. CHPV infection triggered the activation of signalling pathways mediated by mitogen-activated protein kinases, including p38, JNK 1 and 2, and nuclear factor kappa B (NF-kappaB). CHPV-induced expression of CXCL10 and CCL5 was achieved by the activation of p38 and NF-kappaB pathways. Considering the important role of inflammation in neurodegeneration, we have targeted NF-kappaB using a newly synthesised natural product nitrosporeusine analogue and showed incapability of microglial supernatant of inducing apoptosis in neurons after treatment.1 aVerma, Abhishek, Kumar1 aWaghmare, Trushnal, S.1 aJachak, Gorakhnath, R.1 aPhilkhana, Satish, Chandra1 aReddy, Srinivasa1 aBasu, Anirban  uhttps://library.ncl.res.in/content/nitrosporeusine-analogue-ameliorates-chandipura-virus-induced-inflammatory-response-cns-nf01626nas a2200289   4500008004100000022001400041245010400055210006900159260000900228300001400237520066700251653001000918653002200928653002600950653001700976653001600993653002001009100002501029700002101054700002401075700002501099700002101124700002701145700001801172700002101190856012501211       2019                        eng d  a1434-193X00aNeural anti-inflammatory natural product periconianone A: total synthesis and biological evaluation0 aNeural antiinflammatory natural product periconianone A total sy  cAPR   a2376-23813 a<p>Total synthesis of periconianone A, an eremophilane-type sesquiterpenoid with impressive neural anti-inflammatory potential, has been accomplished. Diels-Alder/aldol strategy to construct tetrahydro-naphthalene-2,6-dione scaffold, allylic oxidation of dienone using DBU/O-2 and postulated biomimetic aldol reaction to construct 6/6/6 tricyclic system are the highlights of the present synthesis. Furthermore, the synthesized (+/-)-periconianone A and two close analogs were tested for their neural anti-inflammatory activity using various assays. In the course of our study we found a structurally simplified analog is superior to (+/-)-periconianone A.</p>
10aAldol10aAllylic oxidation10aBiological evaluation10aCytotoxicity10aDiels-Alder10aPericonianone A1 aKalmode, Hanuman, P.1 aPatil, Suhag, S.1 aHandore, Kishor, L.1 aAthawale, Paresh, R.1 aDandela, Rambabu1 aVerma, Abhishek, Kumar1 aBasu, Anirban1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/neural-anti-inflammatory-natural-product-periconianone-total-synthesis-and-biological