01675nas a2200229   4500008004100000022001400041245008100055210006900136260006900205300000900274490000800283520084100291653003201132653002701164653002501191653002501216653001201241100002401253700003001277700002301307856011501330       2014                        eng d  a0010-854500aHybrid diphosphorus ligands in rhodium catalysed asymmetric hydroformylation0 aHybrid diphosphorus ligands in rhodium catalysed asymmetric hydr  aPO BOX 564, 1001 LAUSANNE, SWITZERLANDbELSEVIER SCIENCE SAcMAR  a1-150 v2623 a<p>This review aims to illustrate recent advances in the application of hybrid diphosphorus ligands for the Rh catalysed hydroformylation of alkenes, discussing the most prevalent classes of hybrid systems, i.e. phosphine-phosphinite, phosphine-phosphonite, phosphine-phosphite, phosphite-phosphoramidite and phosphite-phosphoramidite and comparing their performance with relevant C-2 symmetric counterparts. In order to introduce the field and put the results in context, a short overview on Rh hydroformylation is provided. Available spectroscopic (in situ) data on the coordination modes of hybrid phosphorus ligands and the catalytic performance of these systems in asymmetric hydroformylation of vinyl arenes are reported. Potential avenues for future research are shortly discussed. (C) 2013 Elsevier B.V. All rights reserved.</p>10aAsymmetric hydroformylation10aCatalyst resting state10aHybrid ligand design10aIn situ spectroscopy10aRhodium1 aChikkali, Samir, H.1 avan der Vlugt, Jarl, Ivar1 aReek, Joost, N. H.  uhttps://library.ncl.res.in/content/hybrid-diphosphorus-ligands-rhodium-catalysed-asymmetric-hydroformylation-002178nas a2200217   4500008004100000022001400041245009500055210006900150260000900219490000700228520138400235653003201619653004101651653001901692653003601711653002401747100001901771700002401790700002401814856012201838       2025                        eng d  a1867-388000aRh-Catalyzed Asymmetric Hydroformylation: The Case of Substituted and Heterocyclic Olefins0 aRhCatalyzed Asymmetric Hydroformylation The Case of Substituted   cNOV 0 v173 a<p>
	Asymmetric hydroformylation (AHF) of prochiral alkenes is an efficient way to synthesize optically active aldehydes, which are versatile chiral building blocks for pharmaceuticals, agrochemicals, and other fine chemicals. The purpose of this review is to take stock of developments in the last decade and shed light on the understanding of the field of AHF. So far, most of the literature methods focused on the use of Rh-based catalysts, due to high catalytic activity and excellent chemoselectivity for the aldehydes. Several chiral phosphorus ligands have been successfully developed for Rh-catalyzed AHF reactions. This review examines the role of the substrate/olefins in AHF. Several different types of ``mono-substituted'' terminal olefins (functionalized/nonfunctionalized) with a variety of chiral ligands have been investigated, which show high activity and excellent ee of up to 99%. The AHF of ``di-substituted'' and ``tri-substituted'' olefins is rarely reported. This review summarizes the evolution of chiral ligands for AHF. It discusses the progress made in desymmetrizing hydroformylation. In addition, it highlights important developments in AHF carried out with and without syngas. These advances span a wide variety of alkenes. Additionally, the review offers future approaches in the field of AHF for the synthesis of optically active aldehydes.</p>
10aAsymmetric hydroformylation10aAsymmetric transfer hydroformylation10aChiral ligands10aDesymmetrizing hydroformylation10aSubstituted alkenes1 aTewari, Tanuja1 aKhopade, Kishor, V.1 aChikkali, Samir, H.  uhttps://library.ncl.res.in/content/rh-catalyzed-asymmetric-hydroformylation-case-substituted-and-heterocyclic-olefins