00965nas a2200229 4500008004100000022001400041245005800055210005700113260008600170300001400256490000700270520022900277653002000506653001600526653002200542653001400564653002700578100001500605700001800620700001300638856008400651 2005 eng d a0039-791100aWittig-horner approach for the synthesis of tamoxifen0 aWittighorner approach for the synthesis of tamoxifen a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcMAY a2795-28000 v353 a

A stereoselective synthesis of Z -tamoxifen, a tetra-substituted alkene with antiestrogenic activity, is described. The Wittig-Horner reaction has been employed as the key step to establish the olefin stereochemistry.

10aanticancer drug10aphosphonate10astereoselectivity10aTamoxifen10aWittig-Horner reaction1 aPandey, RK1 aWakharkar, RD1 aKumar, P uhttps://library.ncl.res.in/content/wittig-horner-approach-synthesis-tamoxifen-0