01546nas a2200181   4500008004100000022001400041245012900055210006900184260007900253300001100332490000800343520078600351100002201137700002501159700002101184700003401205856012501239       2014                        eng d  a0031-900700aRole of structure and entropy in determining differences in dynamics for glass formers with different interaction potentials0 aRole of structure and entropy in determining differences in dyna  aONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USAbAMER PHYSICAL SOCcNOV  a2257010 v1133 a<p>We present a study of two model liquids with different interaction potentials, exhibiting similar structure but significantly different dynamics at low temperatures. By evaluating the configurational entropy, we show that the differences in the dynamics of these systems can be understood in terms of their thermodynamic differences. Analyzing their structure, we demonstrate that differences in pair correlation functions between the two systems, through their contribution to the entropy, dominate the differences in their dynamics, and indeed overestimate the differences. Including the contribution of higher order structural correlations to the entropy leads to smaller estimates for the relaxation times, as well as smaller differences between the two studied systems.</p>1 aBanerjee, Atreyee1 aSengupta, Shiladitya1 aSastry, Srikanth1 aBhattacharyya, Sarika, Maitra  uhttps://library.ncl.res.in/content/role-structure-and-entropy-determining-differences-dynamics-glass-formers-different-002541nas a2200313   4500008004100000022001400041245007700055210006900132260008000201300001600281490000800297520150100305653001701806653001801823653001501841653001701856653001301873100002101886700001801907700002001925700001901945700002801964700002001992700002102012700003302033700003202066700002502098856010402123       2016                        eng d  a0027-842400aReporter nanoparticle that monitors its anticancer efficacy in real time0 aReporter nanoparticle that monitors its anticancer efficacy in r  a2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USAbNATL ACAD SCIENCEScAPR  aE2104-E21130 v1133 a<p>The ability to monitor the efficacy of an anticancer treatment in real time can have a critical effect on the outcome. Currently, clinical readouts of efficacy rely on indirect or anatomic measurements, which occur over prolonged time scales postchemotherapy or postimmunotherapy and may not be concordant with the actual effect. Here we describe the biology-inspired engineering of a simple 2-in-1 reporter nanoparticle that not only delivers a cytotoxic or an immunotherapy payload to the tumor but also reports back on the efficacy in real time. The reporter nanoparticles are engineered from a novel two-staged stimuli-responsive polymeric material with an optimal ratio of an enzyme-cleavable drug or immunotherapy (effector elements) and a drug function-activatable reporter element. The spatiotemporally constrained delivery of the effector and the reporter elements in a single nanoparticle produces maximum signal enhancement due to the availability of the reporter element in the same cell as the drug, thereby effectively capturing the temporal apoptosis process. Using chemotherapy-sensitive and chemotherapy-resistant tumors in vivo, we show that the reporter nanoparticles can provide a real-time noninvasive readout of tumor response to chemotherapy. The reporter nanoparticle can also monitor the efficacy of immune checkpoint inhibition in melanoma. The self-reporting capability, for the first time to our knowledge, captures an anticancer nanoparticle in action in vivo.</p>10achemotherapy10aimmunotherapy10amonitoring10ananoparticle10areporter1 aKulkarni, Ashish1 aRao, Poornima1 aNatarajan, Siva1 aGoldman, Aaron1 aSabbisetti, Venkata, S.1 aKhater, Yashika1 aKorimerla, Navya1 aChandrasekar, Vineethkrishna1 aMashelkar, Raghunath, Anant1 aSengupta, Shiladitya  uhttps://library.ncl.res.in/content/reporter-nanoparticle-monitors-its-anticancer-efficacy-real-time