01944nas a2200289   4500008004100000022001400041245009300055210006900148260007100217300001600288490000800304520090600312100002201218700002301240700002501263700002701288700002801315700003201343700002401375700002001399700001901419700001901438700002501457700002201482700002201504856012801526       2015                        eng d  a0002-786300aGelation landscape engineering using a multi-reaction supramolecular hydrogelator system0 aGelation landscape engineering using a multireaction supramolecu  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a14236-142390 v1373 a<p>Simultaneous control of the kinetics and thermodynamics of two different types of covalent chemistry allows pathway selectivity in the formation of hydrogelating molecules from a complex reaction network. This can lead to a range of hydrogel materials with vastly different properties, starting from a set of simple starting compounds and reaction conditions. Chemical reaction between a trialdehyde and the tuberculosis drug isoniazid can form one, two, or three hydrazone connectivity products, meaning kinetic gelation pathways can be addressed. Simultaneously, thermodynamics control the formation of either a keto or an enol tautomer of the products, again resulting in vastly different materials. Overall, this shows that careful navigation of a reaction landscape using both kinetic and thermodynamic selectivity can be used to control material selection from a complex reaction network.</p>1 aFoster, Jamie, S.1 aZurek, Justyna, M.1 aAlmeida, Nuno, M. S.1 aHendriksen, Wouter, E.1 ale Sage, Vincent, A. A.1 aLakshminarayanan, Vasudevan1 aThompson, Amber, L.1 aBanerjee, Rahul1 aEelkema, Rienk1 aMulvana, Helen1 aPaterson, Martin, J.1 avan Esch, Jan, H.1 aLloyd, Gareth, O.  uhttps://library.ncl.res.in/content/gelation-landscape-engineering-using-multi-reaction-supramolecular-hydrogelator-system-0