00993nas a2200205 4500008004100000245008600041210006900127260006600196520021000262100002000472700002200492700002700514700001800541700002100559700002000580700002100600700003600621700002100657856010900678 2017 eng d00aStudies on use of sodium poly acrylate (SPA) for low salt animal skinpreservation0 aStudies on use of sodium poly acrylate SPA for low salt animal s a ITC CHOLA , CHENNAIbCentral Leather Research InstitutecFEB3 aIn this study, commercial sodium poly acrylate (SPA) is used along with sodium chloride for low salt skin preservation. SPA is a super-absorbent polymer which can absorb water many times of its own weight.1 aSandhya, K., V.1 aBrindha, Velappan1 aAbinandan, Sudharsanam1 aVedaraman, N.1 aJohn, Sundar, V.1 aSuresha, P., R.1 aBadiger, Manohar1 aChinnaraj, Velappan, kandukalpa1 aMuralidharan, C. uhttps://library.ncl.res.in/content/studies-use-sodium-poly-acrylate-spa-low-salt-animal-skinpreservation01888nas a2200241 4500008004100000022001400041245010200055210006900157260000800226300001200234490000700246520108100253653002401334653001301358653002601371653001801397100001801415700002201433700002501455700001801480700002101498856012701519 2020 eng d a1380-222400aOne-pot synthesis of bimodal (macro-meso, micro-mesoporous) silica by polyHIPE: parameter studies0 aOnepot synthesis of bimodal macromeso micromesoporous silica by  cFEB a263-2750 v273 a

Porous silica with hierarchical organization of pore structure is desired for a variety of applications such as, chromatography, sensing, control release, scaffold for biomedical applications and catalysis. Highly porous polymers obtained from high internal phase emulsion (HIPE) templating route have attracted increasing attention of researchers due to their hierarchical porous and interconnected structure with high porosity and low density. The novel method adopted in our approach combines redox initiated polymerization using HIPE polymerization and an in-situ sol-gel processing technique followed by calcination to obtain highly porous materials. The obtained materials have reminiscent of polyHIPE morphology containing pores and interconnected pore throats in micrometer size range with mesopores on the wall of macropores. The effect of concentration of TEOS, volume of dispersed phase, crosslinker concentration, shear rate and surfactant concentration as well as variation in calcination temperatures on the properties of silica materials were examined.

10aMesoporous material10aPolyHIPE10aPolymer-silica hybrid10aPorous silica1 aWale, Apparav1 aNalawade, Archana1 aPonrathnam, Surendra1 aRajan, C., R.1 aBadiger, Manohar uhttps://library.ncl.res.in/content/one-pot-synthesis-bimodal-macro-meso-micro-mesoporous-silica-polyhipe-parameter-studies02207nas a2200241 4500008004100000022001400041245009600055210006900151260000800220300001100228490000800239520135800247653002801605653002901633653003201662653004701694100001701741700001701758700002101775700002201796700002101818856012601839 2021 eng d a1751-616100aMechanical and microstructural studies in a polysaccharide-acrylate double network hydrogel0 aMechanical and microstructural studies in a polysaccharideacryla cDEC a1048390 v1243 aPolymeric hydrogels continue to find a wide range of applications. However, a major drawback of hydrogels is the lack of mechanical strength. In this regard, ``Double Network Hydrogels'' (DN) have shown great promise recently. The toughness in DN hydrogels originates from the synergistic effect of two polymeric networks. In this work, we have synthesized a DN hydrogel consisting of a tightly cross linked carboxymethylcellulose (CMC) as the first network and loosely cross linked poly(hydroxyethylacrylate) (PHEA) as a second network (CMC-PHEADN). The required flexibility in the second network (PHEA) was induced by the presence of a small amount of stearyl methacrylate (SM) as a co-monomer in hydroxyl ethyl acrylate (HEA). The compressive strength of the CMC-PEHA-DN hydrogel was found to be 280 times more than that of CMC-SN hydrogel, and the presence of SM in DN hydrogels showed better recovery after deformation. Cell viability studies showed the biocompatibility of DN hydrogels. The micro-structural analysis of DN xerogels by 3D X-ray Microtomography indicated the presence of oriented pores in size range of 30-40 mu m. To the best of our knowledge, Microtomography was used for the first time to study the DN gels. These hydrogels can be used to develop implants that can withstand prolonged stress and expand the life span of implants.10aCarboxymethyl cellulose10aDouble network hydrogels10aPoly(hydroxyethyl acrylate)10aPoly(hydroxyethyl-co-stearyl methacrylate)1 aTorris, Arun1 aNair, Sanoop1 aMol, K., P. Raji1 aSengupta, Poulomi1 aBadiger, Manohar uhttps://library.ncl.res.in/content/mechanical-and-microstructural-studies-polysaccharide-acrylate-double-network-hydrogel13257nas a2200169 45000080041000002450145000412100069001862600008002553000011002634900006002745201260500280100001812885700002012903700001712923700002112940856012612961 2024 eng d00aSilver nanoparticles in electrospun ethyl hydroxy ethyl cellulose-PVA Nanofiber: synthesis, characterization and wound dressing applications0 aSilver nanoparticles in electrospun ethyl hydroxy ethyl cellulos cJUN a1004770 v73 a

Electrospinning is a simple, cost-effective technique and a reproducible process for both synthetic and natural polymers. It is found to be an attractive tool for various applications in biomedical engineering, filtration, protective clothing, catalysis reactions and sensors. Non-ionic cellulose ethers namely Ethyl Hydroxy Ethyl Cellulose (EHEC) is an important polysaccharide which is non-toxic, biocompatible and biodegradable and finds applications as thickening/rheology control agents in paints, cosmetics, detergents, oil recovery and also in the biomedical area. Poly (vinyl alcohol) (PVA) is a semi-crystalline hydrophilic polymer which is highly biocompatible and non-toxic having good thermal and mechanical properties and also high water solubility. Silver shows powerful antimicrobial activity and is non-toxic. It has been used to cure severe burns and chronic ulcers for many decades and is extensively used as an additive in various fields like prostheses, burn treatment, catheters, vascular grafts, dental resin components, ion exchange fibers, stainless steel materials, human skin and coating of medical devices. In the present work, EHEC/PVA nanofibers embedded with silver nanoparticles (AgNPs) are studied for their antibacterial activity using both gram positive and gram negative bacteria. The nanofibers show increase in tensile properties with the addition of silver nano-particles. The AgNPs embedded EHEC/PVA nanofiber mats having 0.5% AgNPs were found to enhance the wound healing with no scar formation in wistar rats. The biological in-vitro and in-vivo studies support the potential of EHEC based nanofibers as excellent bio-materials for the treatment of severe burns and wounds. To the best of our knowledge, this is the first report on the electrospinning of EHEC/PVA nanofibers for wound healing applications.

1 aWali, Ashwini1 aGorain, Mahadeo1 aKundu, Gopal1 aBadiger, Manohar uhttps://library.ncl.res.in/content/silver-nanoparticles-electrospun-ethyl-hydroxy-ethyl-cellulose-pva-nanofiber-synthesis02803nas a2200145 4500008004100000245013200041210006900173260000800242300001200250490000700262520221800269100001802487700002102505856013102526 2025 eng d00aMicrogels of hydrophobically modified-ethyl hydroxy ethyl cellulose (HM-EHEC) with 5-flurouracil for drug delivery applications0 aMicrogels of hydrophobically modifiedethyl hydroxy ethyl cellulo cAUG a212-2180 v203 a

The polysaccharides (e.g. celluloses and proteins) which form the basic building blocks of life, are gaining increased interest in recent times for researchers to develop newer health care products from renewable bio-polymers which are cheaper and easily available with different desirable properties. Gels are highly swollen three dimensional networks of hydrophilic polymers cross-linked by physical or chemical interactions. Our focus was to design and develop a novel microgel system which would effectively deliver the anti-cancer drug to the targeted site by slow and sustained release for longer times. The water soluble hydrophobically modified ethyl hydroxy ethyl cellulose (HM-EHEC) biopolymer was used in the synthesis of microgels by Michael-type addition reaction between the primary hydroxyl groups of HM-EHEC and Divinyl sulphone (DVS) crosslinker using water-in-oil emulsion technique. The microgels obtained were spherical in shape having flower type morphology with average size of 5 to 8 μm. The anti-cancer drug 5-Flurouracil (5-FU) drug was successfully incorporated and around 56% of the 5-FU was released in 72 hours with a loading efficiency of 95%.

The cell viability (MTT assay) studies confirmed the cycto-toxicity on the MDA-MB 231 breast cancer cell line. There was an increase in the cell death with increase in the concentration of microgel containing drug concentration. The HM-EHEC microgels could be effectively used in the form of a topical cream in the skin and breast cancer for on-site slow and targeted delivery.

1 aWali, Ashwini1 aBadiger, Manohar uhttps://library.ncl.res.in/content/microgels-hydrophobically-modified-ethyl-hydroxy-ethyl-cellulose-hm-ehec-5-flurouracil-drug