02501nas a2200193   4500008004100000022001400041245009300055210006900148260007100217300001400288490000700302520174800309100002802057700002102085700002502106700002102131700002902152856012602181       2007                        eng d  a0888-588500aEnvironmentally benign catalytic hydroformylation-oxidation route for naproxen synthesis0 aEnvironmentally benign catalytic hydroformylationoxidation route  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcDEC  a8480-84890 v463 a<p>Hydroformylation of 6-methoxy-2-vinylnaphthalene (MVN), using homogeneous Rh(CO)acac) as a catalyst and a chelating bidentate ligand (1,2-bis-(diphenylphosphino) ethane, dppe), followed by oxidation of the product (2-(6-methoxynaphthyl) propanal, 2-MNP) has been studied as an alternative route for the synthesis Of D,L-naproxen. The feasibility of the MVN hydroformylation route has been demonstrated, and a detailed study has been reported on the key hydroformylation step. The roles of the catalyst, ligands, and solvents, as well as the effect of reaction conditions on the reaction rate and regioselectivity of the product 2-MNP, have been investigated. With Rh(CO)2(acac) as a catalyst and dppe as a ligand, &gt; 98% selectivity to 2-MNP (an important precursor to D,L-naproxen) has been achieved. A possible mechanism to explain the variation in regioselectivity with Rh(CO)(2)(acac) as a catalyst and dppe as a ligand has been discussed. The kinetics of the hydroformylation step has been investigated and a rate equation has been proposed. The second step in the proposed route for naproxen-the oxidation of 2-MNP to 2-(6-methoxynaphthyl) propanoic acid (2-MNPA, or naproxen) - has been studied using Na2WO4 as a catalyst and tetrabutyl ammonium hydrogen sulfate (TBAHS) as the phase-transfer catalyst with H2O2 as the oxidant for the first time. Screening of the catalysts that consisted of the early transition metals, such as salts of tungsten, vanadium, and molybdenum showed that Na2WO4 gives the best performance for the oxidation step with &gt; 80% selectivity to 2-(6-methoxynaphthyl)propanoic acid (2-MNPA/naproxen). This study would be valuable in developing a new environmentally benign route for naproxen synthesis.</p>1 aRajurkar, Kalpendra, B.1 aTonde, Sunil, S.1 aDidgikar, Mahesh, R.1 aJoshi, Sunil, S.1 aChaudhari, Raghunath, V.  uhttps://library.ncl.res.in/content/environmentally-benign-catalytic-hydroformylation-oxidation-route-naproxen-synthesis-001490nas a2200241   4500008004100000022001400041245008000055210006900135260000800204300001200212490000700224520074000231653001800971653001800989653002101007653001301028653001401041653001401055100002101069700002801090700002101118856010901139       2025                        eng d  a0538-806600aKinetic investigation on palladium-catalyzed carbonylation of allyl alcohol0 aKinetic investigation on palladiumcatalyzed carbonylation of all  cOCT  a153-1630 v573 a<p>
	Palladium-catalyzed carbonylation of allyl alcohol to 3-butenoic acid has been investigated. A significant effect of halide promoters, p-tolylsulfonic acid (TsOH), water, solvents, and PPh3 concentration activity and selectivity has been studied. Detailed kinetics of this reaction was investigated in a temperature range of 363-383 K. The influence of parameters such as stirring speed, allyl alcohol, catalyst, benzyltriethylammonium chloride (BTEAC), TsOH concentrations, and CO partial pressures on the activity and selectivity has been studied. An empirical rate equation was suggested and found to be fairly consistent with observed rate data. In addition, the activation energy and kinetic parameters were evaluated.</p>
10aallyl alcohol10aCarbonylation10ahalide promoters10akinetics10aMechanism10aPalladium1 aTonde, Sunil, S.1 aRajurkar, Kalpendra, B.1 aPagar, Nitin, S.  uhttps://library.ncl.res.in/content/kinetic-investigation-palladium-catalyzed-carbonylation-allyl-alcohol