02104nas a2200241   4500008004100000022001400041245010000055210006900155260000800224300001400232490000700246520127000253653001501523653003001538653001601568653002901584653002201613100002701635700002701662700002401689700002301713856012601736       2018                        eng d  a1860-539700aAssessing the possibilities of designing a unified multistep continuous flow synthesis platform0 aAssessing the possibilities of designing a unified multistep con  cJUL  a1917-19360 v143 a<p>The multistep flow synthesis of complex molecules has gained momentum over the last few years. A wide range of reaction types and conditions have been integrated seamlessly on a single platform including in-line separation as well as monitoring. Beyond merely getting considered as `flow version' of conventional `one-pot synthesis', multistep flow synthesis has become the next generation tool for creating libraries of new molecules. Here we give a more `engineering' look at the possibility of developing a `unified multistep flow synthesis platform'. A detailed analysis of various scenarios is presented considering 4 different classes of drugs already reported in the literature. The possible complexities that an automated and controlled platform needs to handle are also discussed in detail. Three different design approaches are proposed: (i) one molecule at a time, (ii) many molecules at a time and (iii) cybernetic approach. Each approach would lead to the effortless integration of different synthesis stages and also at different synthesis scales. While one may expect such a platform to operate like a `driverless car' or a `robo chemist' or a `transformer', in reality, such an envisaged system would be much more complex than these examples.</p>10aautomation10acontinuous flow synthesis10acybernetics10amultistep flow synthesis10aunified platforms1 aSharma, Mrityunjay, K.1 aAcharya, Roopashri, B.1 aShukla, Chinmay, A.1 aKulkarni, Amol, A.  uhttps://library.ncl.res.in/content/assessing-possibilities-designing-unified-multistep-continuous-flow-synthesis-platform