01768nas a2200229 4500008004100000022001400041245009600055210006900151260010600220300001000326490000700336520090900343653001401252653001501266653001701281653003001298653001901328100001701347700002501364700001901389856013001408 2014 eng d a0014-305700aSynthesis and characterization of hypercrosslinked hydroxyl functionalized co-polymer beads0 aSynthesis and characterization of hypercrosslinked hydroxyl func aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT a46-580 v593 a

Hydroxyl functionalized beaded copolymers were synthesized from 2-hydroxy ethyl methacrylate by suspension polymerization using two different crosslinking agents (EDMA, DVB) and diluents (1,1,2,2-tetrachloroethane, 1,2-dichlorobenzene). Microporous beads with high surface area were successfully synthesized and characterized by different techniques. Maximum surface area obtained was 564 m(2)/g bearing uniform, spherical as well as non-aggregation images of beads. Thermal properties such as DTG and DSC reveal that, type of crosslinker (flexible/rigid) is major while its concentration is minor parameter that affect decomposition and softening temperature of copolymer. Swelling ratio of copolymer beads was examined as a function of crosslinker and crosslink density. Swelling behavior is in accordance with copolymer-solvent interaction parameter. (C) 2014 Elsevier Ltd. All rights reserved.

10aCopolymer10aMorphology10asurface area10aSuspension polymerization10aSwelling ratio1 aMane, Sachin1 aPonrathnam, Surendra1 aChavan, Nayaku uhttps://library.ncl.res.in/content/synthesis-and-characterization-hypercrosslinked-hydroxyl-functionalized-co-polymer-beads-002180nas a2200229 4500008004100000022001400041245009000055210006900145260009200214300001200306490000700318520130800325653002501633653003601658653002301694653003101717653001701748100001701765700002501782700001901807856012401826 2015 eng d a1385-772X00aDesign and synthesis of cauliflower-shaped hydroxyl functionalized core-shell polymer0 aDesign and synthesis of cauliflowershaped hydroxyl functionalize a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcNOV a723-7330 v183 a

Conventional crosslinked polymers and homopolymers both have their own limitations. As a result, core-shell polymer was synthesized to obtain cauliflower-shaped and highly hydroxyl functionalized polymer. For the core, acrylate-based copolymers were synthesized by varying crosslinkers and porogens at different crosslink density. Owing to high surface area (554 m(2)/g), poly(MMA-co-DVB) was used as a core and low-molecular weight (24,600g/mol) poly(GMA) was used as a shell in core-shell approach. Average particle sizes of the core polymers were in the range of 15-75 mu m. In order to evaluate reactivity efficiency of core-shell polymer, hydroxyl content was evaluated with a value of 3.97mmol/g. Importantly, hydroxyl content demonstrated the successful increase in reactive sites of the core-shell polymer over conventional crosslinked hydroxyl polymer. Notably, synthesized core-shell polymer has more surface area and pore volume which substantially attributes for better polymer efficiency during application. Scanning electron microscopy images revealed the spherical, uniform, and slightly conglomerated properties of core-shell polymer. Due to higher reactivity, insolubility, and more surface area of hydroxyl functionalized core-shell polymer, its use become inevitably essential.

10aC-13 solid state NMR10acauliflower-shaped porous beads10acore-shell polymer10ahydroxyl functionalization10asurface area1 aMane, Sachin1 aPonrathnam, Surendra1 aChavan, Nayaku uhttps://library.ncl.res.in/content/design-and-synthesis-cauliflower-shaped-hydroxyl-functionalized-core-shell-polymer-002279nas a2200169 4500008004100000022001400041245014700055210006900202260011000271300001400381490000700395520151500402100001701917700002501934700001901959856013101978 2015 eng d a1144-054600aHyperhydrophilic three-dimensional crosslinked beads as an effective drug carrier in acidic medium: adsorption isotherm and kinetics appraisal0 aHyperhydrophilic threedimensional crosslinked beads as an effect aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN a3835-38440 v393 a

Conventional drug delivery materials are known to provide slow and low drug loading in aqueous medium due to the hydrophobic or less hydrophilic properties of the carrier. However, the present study explored the synthesis of cheaply available metals modified with a hyperhydrophilic polymer. Hyperhydrophilic three-dimensional crosslinked beads as a drug carrier were synthesized with desirable properties that substantially influence the polymer efficiency. These synthesized polymers were characterized for surface area, particle size, acid content and morphology, and the metal modification was evaluated to obtain an efficient polymer for drug adsorption in an acidic medium. Contact time, which significantly affects drug adsorption was comparatively evaluated using the cheaply available metals, cobalt and nickel. Interestingly, an adsorption study revealed that gradual drug loading occurs during the initial 12 h. Afterwards, adsorption increases steadily and then stabilizes. Furthermore, theoretical predictions of adsorption, including Langmuir adsorption isotherm and pseudo order kinetics, were also evaluated. Remarkably, polymer supported Co/Ni demonstrated 85 and 78% metoprolol drug adsorption, respectively, at an optimum pH of 3 after 24 h. Langmuir adsorption isotherm revealed monolayer adsorption on the polymer supported Co/Ni. Pseudo first and second order kinetics were also evaluated and demonstrated the adsorption mechanism and equilibrium adsorption capacity, respectively.

1 aMane, Sachin1 aPonrathnam, Surendra1 aChavan, Nayaku uhttps://library.ncl.res.in/content/hyperhydrophilic-three-dimensional-crosslinked-beads-effective-drug-carrier-acidic-medium-001914nas a2200169 4500008004100000022001400041245013300055210006900188260007100257300001400328490000700342520120700349100001701556700002501573700001901598856012701617 2015 eng d a0888-588500aRole of interfacial tension of solvating diluents and hydrophilic-hydrophobic cross-linkers in hyper-cross-linked solid supports0 aRole of interfacial tension of solvating diluents and hydrophili a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUL a6893-69010 v543 a

The properties of a hyper-cross-linked solid support are the outcome Of the interfacial tension created by solvating/nonsolvating diluents, the hydrophilicity/hydrophobicity of the cross-linkers, and their concentrations. Interestingly, a More hydrophobic diluent and cross-linker as well as a higher concentration of cross-linker-containing copolymer revealed an increase In surface area. A high surface area and low cross-link density (CLD) polymer illustrated higher epoxy content. Importantly, maximum surface area (533 m(2)/g) Was obtained at high CLD; inversely, epoxy,content (1.83 mmol/g) was higher at low CLD polymer. Notably, greater rigidity of cross-linker and its higher concentration increased T-max and T-g; contrarily, greater flexibility of cross-linker and its concentration attenuated T-max and T-g. Thermal study demonstrated the thermostability (300 degrees C) and polymer safe temperature (220 degrees C). Indeed, a lower solubility parameter difference between polymer and swelling solvent produces a higher polymer-solvent interaction parameter, resulting in increased polymer swelling. Polymers with high surface area and low CLD demonstrated greater swelling behavior.

1 aMane, Sachin1 aPonrathnam, Surendra1 aChavan, Nayaku uhttps://library.ncl.res.in/content/role-interfacial-tension-solvating-diluents-and-hydrophilic-hydrophobic-cross-linkers-001860nas a2200241 4500008004100000022001400041245008100055210006900136260010200205300001400307490000700321520098000328653001201308653003101320653001201351653003201363653002901395100001701424700001801441700002501459700001901484856011501503 2015 eng d a0250-470700aSynthesis and characterization of thermotropic liquid crystalline polyimides0 aSynthesis and characterization of thermotropic liquid crystallin aC V RAMAN AVENUE, SADASHIVANAGAR, P B \#8005, BANGALORE 560 080, INDIAbINDIAN ACAD SCIENCEScOCT a1553-15590 v383 a

Non-symmetrical and linear dyad-based mesogens were synthesised containing imine or ester bridging group. In the present work, due to the absence of branching in diamine-based mesogen, the structure has-rigidity inversely imine/ester bridging groups between two benzene rings imparts-flexible property to the mesogen and consequently rigid-flexible property has been balanced. The synthesised mesogens were characterized by different techniques including nuclear magnetic resonance and Fourier transform infrared spectroscopy. Liquid crystalline polymers (LCPs) were synthesised using pyromellitic dianhydride and 4-[(4-aminobenzylidene)amino]aniline or 4-aminophenyl-4-aminobenzoate. Subsequently, thermotropic liquid crystalline polymers (TLCPs) have also been evaluated to obtain optical microscopy textures at different temperatures which demonstrated interesting and notable changes. It is worth noting that marble-like textures were observed upto 200A degrees C.

10aDiamine10aliquid crystalline polymer10amesogen10aoptical microscopy textures10apyromellitic dianhydride1 aMane, Sachin1 aRajan, C., R.1 aPonrathnam, Surendra1 aChavan, Nayaku uhttps://library.ncl.res.in/content/synthesis-and-characterization-thermotropic-liquid-crystalline-polyimides-102107nas a2200241 4500008004100000022001400041245009500055210006900150260007100219300001200290490000700302520123300309653002401542653002401566653002201590653001701612653003301629653001501662100001701677700002501694700001901719856012701738 2016 eng d a0091-403700aCrosslinked polymer embedded Cu/Ag for comparative drug adsorption and kinetics evaluation0 aCrosslinked polymer embedded CuAg for comparative drug adsorptio aKARL JOHANS GATE 5, NO-0154 OSLO, NORWAYbTAYLOR & FRANCIS AScJAN a285-2930 v653 a

Two-dimensional crosslinked polymer (2-DCP) was synthesized for evaluation of drug adsorption and kinetics thereof. Further, polymer properties were evaluated and parameters such as contact time and adsorption isotherm were also studied. Herein, contact time demonstrated 83% and 85% of drug loading in an acidic medium for two-dimensional crosslinked polymer embedded copper and silver (2-DCP-Cu/Ag), respectively in 24h. Initial 4h is the exponential drug loading period whereas drug loading was increased gradually after 4h. Salbutamol loading was well-fitted to Langmuir adsorption isotherm, which indicated a monolayer drug adsorption with respect to 2-DCP-Cu/Ag. Pseudo first- and pseudo second-order kinetics was evaluated to perceive the drug adsorption mechanism and equilibrium adsorption capacity. Monolayer drug adsorption with chemisorption mechanism was observed for 2-DCP-Cu/Ag. In addition to this, decomposition temperature of polymer was 440 and 325 degrees C while glass transition temperature of polymer was 280 and 200 degrees C before and after metal modification, respectively. (A=aqueous phase; B=organic phase; C=drug solution; D=drug loaded polymer; E=enlarged drug loaded polymer.) [GRAPHICS] .

10aAdsorption isotherm10aadsorption kinetics10acrosslink polymer10adrug loading10alangmuir adsorption isotherm10asalbutamol1 aMane, Sachin1 aPonrathnam, Surendra1 aChavan, Nayaku uhttps://library.ncl.res.in/content/crosslinked-polymer-embedded-cuag-comparative-drug-adsorption-and-kinetics-evaluation-101975nas a2200229 4500008004100000022001400041245014000055210006900195260007100264300001200335490000700347520109700354653002401451653002401475653001701499653001801516653002401534100001701558700002501575700001901600856012601619 2016 eng d a0091-403700aInterfacial tension approach toward drug loading with two-dimensional crosslinked polymer embedded gold: adsorption kinetics evaluation0 aInterfacial tension approach toward drug loading with twodimensi aKARL JOHANS GATE 5, NO-0154 OSLO, NORWAYbTAYLOR & FRANCIS AScJAN a168-1750 v653 a

Interfacial tension of drugs with hydrophilic polymer (A) embedded gold resulting into selective drug adsorption, which also affected the drug adsorption kinetics. Two-dimensional crosslinked polymer embedded gold was synthesized for drug loading application in an acidic buffer. Lower interfacial tension of pantoprazole sodium (B) revealed the exponential loading inversely loading was gradual for chloroquine (C) having more interfacial tension with adsorbent. Initial 2 h was the exponential adsorption period for a pantoprazole sodium whereas exponential adsorption begins after 12 h for a chloroquine. Monolayer drug adsorption was obtained because Langmuir adsorption isotherm was obeyed by both drugs. Moreover, pseudo first-and pseudo second-order kinetics was also evaluated which demonstrated that reactive sites of the adsorbent are homogeneous and drug adsorption mechanism is chemisorption and not the physisorption. Thermal analysis was evaluated to confirm the polymer thermostability and glass transition temperature during catalytic applications in thermal reactions.

10aAdsorption isotherm10aadsorption kinetics10adrug loading10adrug polarity10aInterfacial tension1 aMane, Sachin1 aPonrathnam, Surendra1 aChavan, Nayaku uhttps://library.ncl.res.in/content/interfacial-tension-approach-toward-drug-loading-two-dimensional-crosslinked-polymer-001627nas a2200133 4500008004100000245005100041210005000092260000800142300001400150490000600164520122300170100001701393856008301410 2016 eng d00aRacemic drug resolution: a comprehensive guide0 aRacemic drug resolution a comprehensive guide cOCT a7567-75860 v83 aThe human body is amazingly chirally selective, and consequently enantiopure drugs are essential for treating disease. Nearly 50% of drugs are chiral wherein pharmacological activity resides with the eutomer (pharmacologically active enantiomer) whereas the distomer (inactive/less potent/equally potent/different pharmacological activity/toxic enantiomer) metabolizes by a different pathway and creates unnecessary burden on the body. A teratogenic (toxic) isomer in a racemic drug creates sideeffects, genetic diseases, or may cause death in the case of high dosage. Nowadays, market approval of enantiopure drugs has increased exponentially whereas it has tremendously decreased for racemic and achiral drugs. An expensive process is the main drawback in obtaining enantiopure drugs. Different methods such as chromatography, spectroscopy, and thermal analysis are available for optical purity determination. However, only a few chromatographic methods are useful on an industrial scale. In the present review, racemic resolution and optical purity determination methods are discussed with examples. In addition to this, eutomers and distomers of different drugs containing a single chiral center are also reported.1 aMane, Sachin uhttps://library.ncl.res.in/content/racemic-drug-resolution-comprehensive-guide02008nas a2200253 4500008004100000022001400041245011100055210006900166260009900235300000900334490000700343520105300350653002801403653002401431653001701455653002701472653002301499100001701522700002501539700001801564700002501582700001901607856012801626 2016 eng d a0032-386100aRole of aliphatic hydrocarbon content in non-solvating porogens toward porosity of cross-linked microbeads0 aRole of aliphatic hydrocarbon content in nonsolvating porogens t aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcMAR a8-140 v863 a

Megaporous spherical acrylate copolymer beads were synthesized by suspension polymerization using non-solvating porogens. Non-solvating porogens with higher aliphatic hydrocarbon content generated megaporous morphology with lower surface area. Surface area increased and inversely megaporosity was decreased with decrease in the aliphatic hydrocarbon content of porogen. Megaporosity (5.47 mu m) and pore volume of 5.52 cm(3)/g was obtained with n-decanol. Thermal property of copolymer is a function of type (rigidity/flexibility/elemental composition) and concentration (cross-link density) of monomer and cross-linker. Copolymer containing rigid cross-linker (divinylbenzene) had better thermal stability over copolymer with flexible cross-linker (ethylene dimethacrylate). Further, higher concentration of rigid cross-linker or lower concentration of flexible cross-linker enhanced the thermal stability. Porous polymers are potentially recognized as a solid support for solid-phase synthesis. (C) 2016 Elsevier Ltd. All rights reserved.

10aCross-linked microbeads10aInterfacial tension10aMegaporosity10aNon-solvating porogens10aThermal properties1 aMane, Sachin1 aBadiger, Manohar, V.1 aRajan, C., R.1 aPonrathnam, Surendra1 aChavan, Nayaku uhttps://library.ncl.res.in/content/role-aliphatic-hydrocarbon-content-non-solvating-porogens-toward-porosity-cross-linked-001927nas a2200229 4500008004100000022001400041245007200055210006900127260006700196300001000263490000800273520116600281653001501447653001501462653001701477653001301494653002701507100001701534700002501551700001901576856010201595 2016 eng d a0021-899500aSelective solid-phase extraction of metal for water decontamination0 aSelective solidphase extraction of metal for water decontaminati a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcJAN a428490 v1333 a

Metal-contaminated industrial effluent is a major concern for human health. Therefore, the removal of metal is of primary importance. In this study, metals were selectively extracted from water. Selective metal recovery was studied with a crown-ether-based polymer, wherein the selectivity was observed for strontium over lead. Parameters influencing the metal recovery, such as the contact time, adsorbent dosage, and metal-ion concentration, were evaluated. Interestingly, the adsorption rate of strontium was exponentially increased for the initial 4 h, and lead was adsorbed exponentially after 6 h. Notably, 98% strontium adsorption and 64% lead adsorption were obtained in 24 h. The Langmuir adsorption isotherm was in good agreement and demonstrated that the reactive sites of the adsorbent were homogeneous with monolayer metal adsorption with an adsorbent. The Freundlich adsorption isotherm was not obeyed by both metals. The pseudo-first-order and pseudo-second-order kinetics indicated that strontium was adsorbed by chemisorption and lead was adsorbed by physisorption. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 132, 42849.

10aAdsorption10acopolymers10acrosslinking10akinetics10aradical polymerization1 aMane, Sachin1 aPonrathnam, Surendra1 aChavan, Nayaku uhttps://library.ncl.res.in/content/selective-solid-phase-extraction-metal-water-decontamination-1