01549nas a2200169   4500008004100000022001400041245015200055210006900207260010600276300001200382490000700394520077900401100002501180700002301205700002401228856012701252       2005                        eng d  a0040-402000aChelation controlled regiospecific O-substitution of myo-inositol orthoesters: convenient access to orthogonally protected myo-inositol derivatives0 aChelation controlled regiospecific Osubstitution of myoinositol   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a529-5360 v613 a<p>A general method for the completely regioselective protection of the three secondary hydroxyl groups of orthoester derivatives of myo-mositol, utilizing the subtle differences in reactivity exhibited by its alkali metal alkoxides due to differences in their ability to form chelates, is described. This method provides convenient access to orthogonally protected myo-inositol derivatives. A comparison of the methylation of racemic 4-0-trityl-myo-inositol 1,3,5-orthoformate in the presence of sodium or lithium ions showed that stabilization of the C4-alkoxide by chelation with lithium overrides steric hindrance offered by the C6-axial substituent in deciding the regioselectivity during the nucleophilic O-substitution. (C) 2004 Elsevier Ltd. All rights reserved.</p>1 aDevaraj, Subramanian1 aShashidhar, M., S.1 aDixit, Shailesh, S.  uhttps://library.ncl.res.in/content/chelation-controlled-regiospecific-o-substitution-myo-inositol-orthoesters-convenient-001734nas a2200241   4500008004100000022001400041245018600055210006900241260010600310300001400416490000700430520077100437653001601208653001301224653001301237653001101250653001201261653001801273100002401291700002301315700002501338856012901363       2006                        eng d  a0040-402000aCyclitol based metal complexing agents. preference for the extraction of lithium by myo-inositol based crown-4-ethers depends on the relative orientation of crown ether oxygen atoms0 aCyclitol based metal complexing agents preference for the extrac  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY  a4360-43630 v623 a<p>myo-Inositol derived crown-4-ethers in which two of the oxygen atoms in the crown ether moiety have different relative orientations were prepared. Metal picrate binding studies revealed that the crown ether having 1,3-diaxial orientation shows the highest selectivity for binding to lithium although the crown ether having 1,2-diequatorial orientation exhibited the highest binding constant for lithium picrate. These results suggest that relative binding affinity of metal ions to crown ethers can be tuned by varying the relative orientation of crown ether oxygen atoms. The relevance of these results to the previously observed regioselectivity during the O-substitution of myo-inositol orthoesters is discussed. (c) 2606 Elsevier Ltd. All rights reserved.</p>10acrown ether10aCyclitol10aInositol10aligand10alithium10ametal complex1 aDixit, Shailesh, S.1 aShashidhar, M., S.1 aDevaraj, Subramanian  uhttps://library.ncl.res.in/content/cyclitol-based-metal-complexing-agents-preference-extraction-lithium-myo-inositol-based-001712nas a2200229   4500008004100000022001400041245016500055210006900220260010600289300001400395490000700409520079500416653001601211653001301227653001301240653001101253653001801264653001801282100002401300700002701324856013101351       2008                        eng d  a0040-402000aInositol derived crown ethers: effect of auxiliary protecting groups and the relative orientation of crown ether oxygen atoms on their metal ion binding ability0 aInositol derived crown ethers effect of auxiliary protecting gro  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a2160-21710 v643 a<p>The binding constants of crown ethers prepared from tetra-O-substituted myo- and scyllo-inositol derivatives and 2-O-substituted myo- and scyllo-inositol-1,3,5-orthoformates, with metal picrates show that the O-substituents and the relative orientation of the crown ether oxygen atoms contribute significantly to the binding of crown ethers with metal ions. In particular, the binding efficiency of myo-inositol derived crown ethers to silver and potassium ions could be enhanced by introducing benzyl ethers in the inositol ring. Hence binding efficacy and selectivity of metal ions to inositol derived crown ethers can be tuned by varying substituents on the myo-inositol ring and/or the relative orientation of crown ether oxygen atoms. (C) 2007 Elsevier Ltd. All rights reserved.</p>10acrown ether10aCyclitol10aInositol10aligand10ametal complex10asupramolecule1 aDixit, Shailesh, S.1 aShashidhar, Mysore, S.  uhttps://library.ncl.res.in/content/inositol-derived-crown-ethers-effect-auxiliary-protecting-groups-and-relative-orientation-002382nas a2200313   4500008004100000022001400041245008600055210006900141260009200210300001400302490000600316520133700322653001701659653001901676653001501695653002001710653003301730653001301763653001401776100002401790700001901814700001901833700001901852700001901871700001601890700002001906700002801926856011401954       2016                        eng d  a1947-293500aAnti-oxidant properties of ficus religiosa L. Bark extract on human keratinocytes0 aAntioxidant properties of ficus religiosa L Bark extract on huma  a26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USAbAMER SCIENTIFIC PUBLISHERScJUN  a1221-12260 v83 a<p>Ficus religiosa (Sacred Fig) is a medicinally important tree, native to the Indian subcontinent. It has been extensively pharmacologically researched species having wide spectrum of medicinal properties. All parts of F. religiosa tree are known to possess important medicinal properties such as anti-oxidant, anti-inflammatory, wound healing and skin diseases etc. However, effects of F. religiosa on skin cells line HaCaT was not studied for its antioxidant properties. In this report we have investigated F. religiosa bark aqueous extract for its antioxidant properties on human keratinocytes (HaCaT) cell line using DPPH, superoxide dismutase 1, superoxide dismutase 2 and catalase assay. We observed that F. religiosa bark aqueous extract efficiently scavenged (80%) DPPH radicals. Superoxide dismutase1 assay of F. religiosa bark aqueous extract effectively scavenged superoxide radicals (O-2(-)) and showed dose dependent activity. Reactive oxygen species were trapped by superoxide dismutase 2 assay of F. religiosa bark aqueous extract and form hydrogen peroxide. Catalase assay results revelled that hydrogen peroxide was further decomposed to give water and oxygen. Thus various anti-oxidant assays of F. religiosa bark aqueous extract indicate that it efficiently reduced the reactive oxygen species in skin cells.</p>10aAnti-Oxidant10aCatalase Assay10aDPPH Assay10aFicus religiosa10aKeratinocyte HaCaT Cell Line10aMoraceae10aSOD Assay1 aDixit, Shailesh, S.1 aKulkarni, Atul1 aSeo, Hyo, Hyun1 aGadgil, Jayant1 aDingre, Medini1 aUmar, Ahmad1 aMoh, Sang, Hyun1 aParasharami, Varsha, A.  uhttps://library.ncl.res.in/content/anti-oxidant-properties-ficus-religiosa-l-bark-extract-human-keratinocytes