01126nas a2200157   4500008004100000022001400041245014200055210006900197260010600266300001200372490000700384520040300391100002600794700002000820856012800840       2007                        eng d  a0040-402000aGeneral and efficient route to 3 `-deoxy-3 `-N-, S-, and C-substituted altropyranosyl thymines from 2',3'-O-anhydro-mannopyranosylthymine0 aGeneral and efficient route to 3 deoxy3 N S and Csubstituted alt  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a602-6080 v633 a<p>An efficient route to 1-(2,3-O-anhydro-4,6-O-phenylmethylene–D-mannopyranosyl) thymine from 1,2,4,6-tetra-O-acetyl-3-O-tosyl-beta-D-glucopyranose has been devised. This newly synthesized epoxide is opened up regioselectively at the C-3'-position by N-, S-, and C-nucleophiles to afford a wide range of new 3-deoxy-3'-substituted altropyranosyl thymines. (c) 2006 Published by Elsevier Ltd.</p>1 aDeshpande, Sachin, G.1 aPathak, Tanmaya  uhttps://library.ncl.res.in/content/general-and-efficient-route-3-deoxy-3-n-s-and-c-substituted-altropyranosyl-thymines-23-o01705nas a2200229   4500008004100000022001400041245010000055210006900155260009900224300001400323490000800337520079800345653001101143653003001154653002101184653002801205653003901233100002601272700003001298700002001328856012701348       2008                        eng d  a0008-621500aStudies on the synthesis and unusual behavior of vinyl sulfone-modified hexenopyranosylthymines0 aStudies on the synthesis and unusual behavior of vinyl sulfonemo  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcMAY  a1163-11700 v3433 a<p>Although vinyl sulfone-modified- (VSM) pent-2-enofuranosyl nucleosides 2 and hex-2-enopyranosyl glycoside 4 are easily synthesized from the corresponding mesylated sulfones le and 3c, respectively, via an oxidation-mesylation-elimination route, the 3'-C-sulfonyl-hex-2'-enopyranosylthymine 11 is not obtained from 10 and a glycal derivative 12 is formed instead. On the other hand, 3-C-sulfonyl-hex-3'-enopyranosylthymine 20 is easily synthesized from the mesylated sulfone 19. Again unlike the reaction patterns of VSM-pent-T-enofuranosyl nucleosides 2 and hex-2-enopyranosyl glycosides 4 as Michael acceptors, the reactions of nucleophiles with 3'-C-sulfonyl-hex-3'-enopyranosylthymine 20 yielded a rearranged product 21 instead of Michael adducts. (c) 2008 Published by Elsevier Ltd.</p>10aglycal10ahexopyranosyl nucleosides10aMichael addition10aunsaturated nucleosides10avinyl sulfone-modified nucleosides1 aDeshpande, Sachin, G.1 aSuresh, Cheravakkattu, G.1 aPathak, Tanmaya  uhttps://library.ncl.res.in/content/studies-synthesis-and-unusual-behavior-vinyl-sulfone-modified-hexenopyranosylthymines-0