01313nas a2200193   4500008004100000022001400041245004800055210004800103260007100151300001300222490000700235520067400242100002300916700002600939700002800965700002200993700002201015856008201037       2008                        eng d  a1083-616000aContinuous flow nitration of salicylic acid0 aContinuous flow nitration of salicylic acid  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcSEP  a995-10000 v123 a<p>Continuous flow nitration of salicylic acid using HNO3/AcOH was studied in the SS316 tubular microreactor. At specific reaction conditions, complete conversion of the reactant was achieved in less than 7 min. It yielded only mononitro derivatives with a higher selectivity of 5-nitrosalicylic acid. Presence of the lower amount of acetic acid in the reaction mixture was seen to be detrimental, leading to precipitation of the desired product (5-nitrosalicylic acid). Reaction at higher temperatures yielded byproducts. The continuous mode operation using the system comprising the microdevices was demonstrated for 2 h with consistent composition at the outlet.</p>1 aKulkarni, Amol, A.1 aNivangune, Nayana, T.1 aKalyani, Vishwanath, S.1 aJoshi, Ramesh, A.1 aJoshi, Rohini, R.  uhttps://library.ncl.res.in/content/continuous-flow-nitration-salicylic-acid-0