01782nas a2200277   4500008004100000022001400041245011000055210006900165260010200234300001200336490000800348520074900356653001701105653001501122653003501137653002301172100002901195700001901224700002301243700002601266700001701292700002001309700002701329700002101356856012701377       2014                        eng d  a0974-362600aDesign, synthesis and cytotoxicity of novel N-benzylpiperidin-4-one oximes on human cervical cancer cells0 aDesign synthesis and cytotoxicity of novel Nbenzylpiperidin4one   aC V RAMAN AVENUE, SADASHIVANAGAR, P B \#8005, BANGALORE 560 080, INDIAbINDIAN ACAD SCIENCEScMAY  a861-8730 v1263 a<p>A series of fifteen diversified N-benzylpiperidin-4-one oximes were synthesized and characterized by their NMR spectral data. Additionally, single-crystal XRD analysis was performed for the representative symmetrically and unsymmetrically substituted molecules. All the synthesized oximes from unsymmetrical ketones existed as E-isomer as witnessed by their NMR and XRD data. Among the synthesized target compounds that evaluated for their in vitro cytotoxicity against human cervical carcinoma (HeLa) cells, five compounds were potent with IC50 &lt; 17 mu M. 1-Benzyl-2,6-bis(4-isopropylphenyl)-3-methylpiperidin-4-one oxime 3c with an IC50 of 13.88 mu M was found to be the best active compound as depicted by the microscopic analysis.</p>10aCytotoxicity10aHeLa cells10aN-benzylpiperidin-4-one oximes10asingle-crystal XRD1 aDindulkar, Someshwar, D.1 aBhatnagar, Ira1 aGawade, Rupesh, L.1 aPuranik, Vedavati, G.1 aKim, Se-Kwon1 aAnh, Dong, Hyun1 aParthiban, Paramasivam1 aJeong, Yeon, Tae  uhttps://library.ncl.res.in/content/design-synthesis-and-cytotoxicity-novel-n-benzylpiperidin-4-one-oximes-human-cervical-0