01085nas a2200169   4500008004100000022001400041245013600055210006900191260009300260300001200353490000700365520035900372100002500731700002100756700002200777856011600799       2007                        eng d  a0004-942500aSyntheses of 1,2-amino alcohols and their applications for oxazaborolidine catalyzed enantioselective reduction of aromatic ketones0 aSyntheses of 12amino alcohols and their applications for oxazabo  a150 OXFORD ST, PO BOX 1139, COLLINGWOOD, VICTORIA 3066, AUSTRALIAbCSIRO PUBLISHINGcAPR  a196-2040 v603 a<p>Six new chiral 1,2-amino alcohol derivatives have been synthesized starting from (1R, 2R)-2-amino-1-phenylpropane-1,3- diol. Asymmetric reduction of aryl ketones with in-situ generated oxazaborolidine from these amino alcohol derivatives and BH3 center dot Me2S afforded secondary alcohols with good yield and moderate to high enantiomeric excess.</p>1 aVatmurge, Namdev, S.1 aHazra, Braja, G.1 aPore, Vandana, S.  uhttps://library.ncl.res.in/content/syntheses-12-amino-alcohols-and-their-applications-oxazaborolidine-catalyzed01337nas a2200205   4500008004100000022001400041245009700055210006900152260010600221300001400327490000700341520051900348100002500867700002100892700002200913700001900935700002400954700002600978856012701004       2008                        eng d  a0960-894X00aSynthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole0 aSynthesis and antimicrobial activity of betalactambile acid conj  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a2043-20470 v183 a<p>Synthesis of novel 1,2,3-triazole-linked beta-lactam-bile acid conjugates 17-24 using 1,3-dipolar cycloaddition reaction of azido beta-lactam and terminal alkyne of bile acids in the presence of Cu( I) catalyst ( click chemistry) have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and moderate antibacterial activity against all the tested strains. (c) 2008 Elsevier Ltd. All rights reserved.</p>1 aVatmurge, Namdev, S.1 aHazra, Braja, G.1 aPore, Vandana, S.1 aShirazi, Fazal1 aChavan, Pradnya, S.1 aDeshpande, Mukund, V.  uhttps://library.ncl.res.in/content/synthesis-and-antimicrobial-activity-beta-lactam-bile-acid-conjugates-linked-triazole-001609nas a2200229   4500008004100000022001400041245010700055210006900162260011000231300001400341490000600355520070600361100002501067700002101092700002201113700001901135700002601154700002301180700002501203700002401228856012701252       2008                        eng d  a1477-052000aSynthesis and biological evaluation of bile acid dimers linked with 1,2,3-triazole and bis-beta-lactam0 aSynthesis and biological evaluation of bile acid dimers linked w  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT  a3823-38300 v63 a<p>We report herein the synthesis and biological evaluation of bile acid dimers 11-18 linked through 1,2,3-triazole and bis-beta-lactam. The dimers 11-18 were synthesized using 1,3-dipolar cycloaddition reaction of diazido bis-beta-lactams 3, 4 and terminal alkynes 7-10 derived from cholic acid/deoxycholic acid in the presence of Cu(I) catalyst (click chemistry). These novel molecules were evaluated in vitro for their antifungal and antibacterial activity. Most of the compounds exhibited significant antifungal as well as antibacterial activity against all the tested fungal and bacterial strains. Moreover, their in vitro cytotoxicities towards HEK-293 and MCF-7 cells were also established.</p>1 aVatmurge, Namdev, S.1 aHazra, Braja, G.1 aPore, Vandana, S.1 aShirazi, Fazal1 aDeshpande, Mukund, V.1 aKadreppa, Sreenath1 aChattopadhyay, Samit1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/synthesis-and-biological-evaluation-bile-acid-dimers-linked-123-triazole-and-bis-beta-0