01301nas a2200205   4500008004100000022001400041245013300055210006900188260007100257300001400328490000700342520049000349100002100839700001900860700001700879700001900896700002500915700002300940856013200963       2005                        eng d  a0022-326300aCopper- and ligand-free sonogashira reaction catalyzed by Pd(0) nanoparticles at ambient conditions under ultrasound irradiation0 aCopper and ligandfree sonogashira reaction catalyzed by Pd0 nano  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUN  a4869-48720 v703 a<p>The Sonogashira reaction proceeds at ambient temperature (30 degrees C) in acetone or room-temperature ionic liquid, 1,3-di-n-butylimidazolium tetrafluoroborate ([bbim]BF4), as solvent under ultrasound irradiation to give enhanced reaction rates, excellent chemoselectivity, and high yields in the absence of a copper cocatalyst and a phosphine ligand. TEM analysis showed the formation of stable, crystalline, and polydispersed Pd(0) nanoparticles as catalyst for the reaction.</p>1 aGholap, Atul, R.1 aVenkatesan, K.1 aPasricha, R.1 aDaniel, Thomas1 aLahoti, Rajgopal, J.1 aSrinivasan, K., V.  uhttps://library.ncl.res.in/content/copper-and-ligand-free-sonogashira-reaction-catalyzed-pd0-nanoparticles-ambient-conditions-101322nas a2200253   4500008004100000022001400041245017700055210006900232260009500301300001000396490000800406520026600414653003600680653002300716653002300739653005100762653002700813100002100840700001900861700001900880700002500899700002300924856012100947       2006                        eng d  a0021-951700aRemarkably rapid regioselective synthesis of beta-enaminones using silica chloride in a heterogeneous as well as an ionic liquid in a homogeneous medium at room temperature0 aRemarkably rapid regioselective synthesis of betaenaminones usin  a525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USAbACADEMIC PRESS INC ELSEVIER SCIENCEcFEB  a37-460 v2453 a<p>{Silica chloride as a heterogeneous catalyst has been used for the regioselective synthesis of P-amino-a,P unsaturated esters and ketones. Similar regioselective synthesis was also performed using an ionic liquid 1-n-butyl imidazolium tetrafluoroborate [</p>10adirect oxidation of H-2 to H2O210aH2O2 decomposition10aH2O2 hydrogenation10aPromoting action of chloride or bromide anions10asupported Pd catalysts1 aGholap, Atul, R.1 aChakor, N., S.1 aDaniel, Thomas1 aLahoti, Rajgopal, J.1 aSrinivasan, K., V.  uhttps://library.ncl.res.in/content/remarkably-rapid-regioselective-synthesis-beta-enaminones-using-silica-chloride-101684nas a2200277   4500008004100000022001400041245016300055210006900218260010600287300001400393490000700407520057500414653002400989653003101013653002801044653003101072653002101103100002101124700002001145700001901165700001801184700002301202700002601225700002601251856012901277       2007                        eng d  a0968-089600aSynthesis and evaluation of antifungal properties of a series of the novel 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and its analogues0 aSynthesis and evaluation of antifungal properties of a series of  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6705-67150 v153 a<p>A series of 2-amino-5-oxo-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile and various analogues have been synthesized in excellent isolated yields starting from various arylidenemalononitrile and 3-amino-2-cyclohexen-1-one in 1-propanol as solvent at reflux temperature in the absence of any added catalyst. All the synthesized compounds were evaluated for their antifungal activity. The relationship between functional group variation and biological activity of the evaluated compounds is discussed in the article. (C) 2007 Elsevier Ltd. All rights reserved.</p>10aAntifungal activity10aantiproliferative activity10aarylidenemalononitriles10aarylquinoline carbonitrile10aMichael addition1 aGholap, Atul, R.1 aToti, Kiran, S.1 aShirazi, Fazal1 aKumari, Ratna1 aBhat, Manoj, Kumar1 aDeshpande, Mukund, V.1 aSrinivasan, Kumar, V.  uhttps://library.ncl.res.in/content/synthesis-and-evaluation-antifungal-properties-series-novel-2-amino-5-oxo-4-phenyl-5678-001714nas a2200265   4500008004100000022001400041245016400055210006900219260010600288300001600394490000700410520067400417653002601091653002401117653001701141653001401158653001601172653002001188100002101208700002001229700001901249700002601268700002601294856012801320       2008                        eng d  a0040-402000aEfficient synthesis of antifungal pyrimidines via palladium catalyzed Suzuki/Sonogashira cross-coupling reaction from Biginelli 3,4-dihydropyrimidin-2(1H)-ones0 aEfficient synthesis of antifungal pyrimidines via palladium cata  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a10214-102230 v643 a<p>An efficient regioselective approach to the synthesis of tetrasubstituted pyrimidines was developed by sequential functionalization of easily available Biginelli 3,4-dihydropyrimidine-2(1H)-ones via dehydrogenation, chlorination followed by palladium catalyzed C-C Suzuki/Sonogashira coupling reaction. All the synthesized compounds were evaluated in vitro for their antifungal activities against Candida albicans, Cryptococcus neoformans, Benjaminiella poitrasii, Yarrowia lipolytica, and Fusarium oxysporum, and antibacterial activities against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. (c) 2008 Elsevier Ltd. All rights reserved.</p>10aAntifungal activities10aBiginelli compounds10achlorination10aOxidation10aPyrimidines10aSuzuki coupling1 aGholap, Atul, R.1 aToti, Kiran, S.1 aShirazi, Fazal1 aDeshpande, Mukund, V.1 aSrinivasan, Kumar, V.  uhttps://library.ncl.res.in/content/efficient-synthesis-antifungal-pyrimidines-palladium-catalyzed-suzukisonogashira-cross-001625nas a2200217   4500008004100000022001400041245010200055210006900157260008600226300001400312490000700326520081000333653001701143653001601160653002101176653002301197100002101220700001801241700002601259856012201285       2008                        eng d  a0039-791100aNovel process for the synthesis of class I antiarrhythmic agent (+/-)-cibenzoline and its analogs0 aNovel process for the synthesis of class I antiarrhythmic agent   a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcAUG  a2967-29820 v383 a<p>Synthesis of (+/-)-cibenzoline and its analogs has been achieved by a simple sequence of reactions. The diaryl cyanoolefin intermediate 3 could be prepared by Knoevenagel condensation of benzophenone with ethylcyanoacetate to form the tetra-substituted olefin intermediate 2 followed by Krapcho deethoxycarbonylation or from beta-hydroxynitrile intermediate 2' followed by the elimination of hydroxyl group respectively. The 2,2-diphenylcyclopropanecarbonitrile 4 was synthesized from intermediate 3 by cyclopropanation, which was converted to (+/-)-2-(2,2-diphenylcyclopropyl)-2-imidazoline 5 by reaction with ethylenediamine in the presence of a catalytic amount of sulfur. Moreover, the obtained 2-imidazolines were smoothly oxidized to the corresponding imidazoles 6 in good to moderate yields.</p>10aBenzophenone10acibenzoline10acyclopropanation10adiaryl cyanoolefin1 aGholap, Atul, R.1 aPaul, Vincent1 aSrinivasan, Kumar, V.  uhttps://library.ncl.res.in/content/novel-process-synthesis-class-i-antiarrhythmic-agent-cibenzoline-and-its-analogs-0