01806nas a2200301   4500008004100000022001400041245008900055210006900144260007300213300001400286490000800300520081000308653002701118653001601145653001301161653001701174653002501191653001001216653001001226100001801236700002201254700002701276700001601303700001701319700002601336700002601362856011601388       2008                        eng d  a0014-579300aTaxol and 10-deacetylbaccatinIII induce distinct changes in the dynamics of caveolae0 aTaxol and 10deacetylbaccatinIII induce distinct changes in the d  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcOCT  a3595-36000 v5823 a<p>Taxol treatment of HeLa cells resulted in a transient recruitment of Caveolin-1 to the cell surface followed by internalization. Interestingly, 20 min after 10-deacetylbaccatinIII (10-DAB) treatment, the caveolae displayed faster `kiss and run' dynamics while BaccatinIII (BacIII) did not induce any change. Sustained phosphorylation of Caveolin-1 is observed upon treatment and between Taxol and 10-DAB, the former shows phosphorylated Raf-1, ERK1/2 and hyperphosphorylated Bcl-2 while the later showed much less magnitude of the same. BacIII treatment did not induce phosphorylation of Raf-1 or Bcl-2. It is possible that Taxol might act on multiple targets and the side chain may be crucial. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.</p>10a10-DeacetylbaccatinIII10aBaccatinIII10aCaveolae10aCytotoxicity10aKiss and run dynamic10aTaxol10aTIRFM1 aAhmed, Neesar1 aDasari, Sreekanth1 aSrivastava, Saumya, S.1 aSneh, Amita1 aAhmad, Absar1 aKhan, Mohammad, Islam1 aKrishnasastry, M., V.  uhttps://library.ncl.res.in/content/taxol-and-10-deacetylbaccatiniii-induce-distinct-changes-dynamics-caveolae-002321nas a2200289   4500008004100000022001400041245013600055210006900191260011100260300001200371490000700383520126500390653002001655653003401675653001401709653001601723653001601739100001401755700001801769700001501787700001401802700002201816700002601838700002301864700001801887856012601905       2012                        eng d  a1566-524000aAndrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 Kinase/Akt signaling pathway0 aAndrographolide inhibits osteopontin expression and breast tumor  aEXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATESbBENTHAM SCIENCE PUBL LTDcSEP  a952-9660 v123 a<p>Breast cancer is one of the most common cancers among women in India and around the world. Despite recent advancement in the treatment of breast cancer, the results of chemotherapy to date remain unsatisfactory, prompting a need to identify natural agents that could target cancer efficiently with least side effects. Andrographolide (Andro) is one such molecule which has been shown to possess inhibitory effect on cancer cell growth. In this study, Andro, a natural diterpenoid lactone isolated from Andrographis paniculata has been shown to inhibit breast cancer cell proliferation, migration and arrest cell cycle at G2/M phase and induces apoptosis through caspase independent pathway. Our experimental evidences suggest that Andro attenuates endothelial cell motility and tumor-endothelial cell interaction. Moreover, Andro suppresses breast tumor growth in orthotopic NOD/SCID mice model. The anti-tumor activity of Andro in both in vitro and in vivo model was correlated with down regulation of PI3 kinase/Akt activation and inhibition of pro-angiogenic molecules such as OPN and VEGF expressions. Collectively, these results demonstrate that Andro may act as an effective anti-tumor and anti-angiogenic agent for the treatment of breast cancer.</p>10aAndrographolide10aangiogenesis and breast tumor10amigration10aosteopontin10aPI 3 kinase1 aKumar, S.1 aPatil, H., S.1 aSharma, P.1 aKumar, D.1 aDasari, Sreekanth1 aPuranik, Vedavati, G.1 aThulasiram, H., V.1 aKundu, G., C.  uhttps://library.ncl.res.in/content/andrographolide-inhibits-osteopontin-expression-and-breast-tumor-growth-through-down-0