01463nas a2200193   4500008004100000022001400041245011000055210006900165260011000234300001400344490000600358520065200364100001901016700002601035700002401061700002601085700002601111856013201137       2009                        eng d  a1477-052000aSynthesis of polyfunctional quinolizidine alkaloids: development towards selective glycosidase inhibitors0 aSynthesis of polyfunctional quinolizidine alkaloids development   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUN  a3300-33070 v73 a<p>A highly divergent route to a variety of quinolizidine alkaloids is described. The enantiomeric precursors 22a and 22b utilized for the synthesis of these alkaloids were constructed stereospecifically from the PET cyclization of the corresponding acetylene tethered alpha-trimethylsilyl amine moieties 21a and 21b, respectively, both of which were synthesised from D-ribose. The polyhydroxy quinolizidine alkaloid 7 was found to be a selective inhibitor of alpha-galactosidase with Ki 83.9 mu M. The amine analogs 18, 12 and 10 are found to be selective and potent inhibitors of alpha-glucosidase with Ki 28, 120 and 140 mu M, respectively.</p>1 aPandey, Ganesh1 aGrahacharya, Debasish1 aShashidhara, K., S.1 aKhan, Mohammad, Islam1 aPuranik, Vedavati, G.  uhttps://library.ncl.res.in/content/synthesis-polyfunctional-quinolizidine-alkaloids-development-towards-selective-glycosidase-0