00962nas a2200181   4500008004100000022001400041245006000055210005700115260008000172300001200252490000700264520031500271100002400586700002600610700002600636700002600662856009200688       2009                        eng d  a0971-162700aGreen and sustainable approach to BIS-(INDOLYL) alkanes0 aGreen and sustainable approach to BISINDOLYL alkanes  aC-85 SECTOR-B, ALIGANJ SCHEME, LUCKNOW, INDIA 226020 USAbDR R S VARMAcJAN  a279-2820 v183 a<p>An efficient, high yielding, green and mild method has been developed for the synthesis of bis (indolyl) methanes using dodecylsulphonic acid as an effective surfactant type Bronsted acid catalyst in aq media. The method is excellent for various new bis-(indolyl) methanes derived from pyrazolaldehydes.</p>1 aGholap, Somnath, S.1 aWakchaure, Prasad, B.1 aPandhare, Gajanan, R.1 aGill, Charansingh, H.  uhttps://library.ncl.res.in/content/green-and-sustainable-approach-bis-indolyl-alkanes-002099nas a2200205   4500008004100000022001500041245009900056210006900155260000900224300001700233490000600250520137800256100002601634700002001660700001901680700002701699700001801726700002401744856012501768       2018                        eng d  a 2365-654900aDesign, synthesis and biological screening of novel 1,3,4-oxadiazoles as antitubercular agents0 aDesign synthesis and biological screening of novel 134oxadiazole  c DEC  a 13304-133100 v33 aA series of novel 2,5-disubstitued 1,3,4-oxadiazole derivatives bearing 2,2-dimethyl-2,3-dihydrobenzofuran scaffold has been synthesized and screened for antitubercular activity. All the synthesized compounds were characterized by IR, H-1 NMR, C-13-NMR and Mass spectral study. The in vitro antitubercular activity of the synthesized compounds was evaluated against Mycobacterium tuberculosis H37Ra(ATCC 25177) strain. Among the synthesized compounds, four compound displayed good antitubercular activity IC50 values in low micro-gram range (<10 mu g/mL). The antitubercular data suggested that growth inhibition MTB can be imparted by the introduction of a 4- trifluoromethyl phenyl acetylene substituent. Specificity of these compounds was checked by screening them for their anti-bacterial activity against four bacterial strains (Gram-negative strains: E. coli, S. aureus; Gram-positive strains: P. aeruginosa and B. subtilis). None of the compound displayed antibacterial activity against any of the seleted strain. Molecular docking studies were carried out on InhA (FabI/ENR) which shows that the synthesized compounds bind at the catalytic site in a most favourable manner suggesting their potential as anti-mycobacterial agents. The research presented here was found to be adventitious for the development of new therapeutic agents against Mycobacterium infection.1 aTambe, Macchindra, S.1 aChoudhari, Amit1 aSarkar, Dhiman1 aSangshetti, Jaiprakash1 aPatil, Rajesh1 aGholap, Somnath, S.  uhttps://library.ncl.res.in/content/design-synthesis-and-biological-screening-novel-134-oxadiazoles-antitubercular-agents