02609nas a2200325   4500008004100000022001400041245011700055210006900172260000800241300001400249490000600263520156100269653002701830653001201857653002201869653001501891653001801906100002301924700001601947700001701963700002301980700001802003700001902021700001602040700002202056700002502078700002502103700002402128856013102152       2022                        eng d  a2637-610500aAlgal biomass-loaded hydrogel scaffolds as a biomimetic platform with antibacterial and wound healing activities0 aAlgal biomassloaded hydrogel scaffolds as a biomimetic platform   cAUG  a5800-58120 v43 a<p>
	The confluence of hydrogel scaffolds and dried algal biomass (AB), consisting of all the bioactive compounds, offers the possibility to facilitate wound healing while simultaneously instilling antibacterial benefits. For this purpose, a single-step synthesis of algal (Chlorella sorokiniana) biomass-loaded hydrogel scaffolds (AHS) was achieved. C. sorokiniana has been used in different areas for several years and has proved attractive to the pharmaceutical and cosmetic industries. Of note, the presence of phytochemicals and various bioactive compounds provides an added health benefit. Hitherto, we report AHS with accelerated wound healing along with potent anti-inflammatory and antibacterial properties. AHS consisting of different concentrations of AB was applied for 14 days on excisional wounds in mice. Microscopic analyses, assessment of proinflammatory and anti-inflammatory cytokines, and histological studies were performed to investigate wound healing. These scaffolds were extensively characterized and studied using Fourier transform infrared, X-ray diffraction, Raman, atomic force microscopy, transmission electron microscopy, scanning electron microscopy, swelling, rheological, thermal, and mechanical analyses. AHS have excellent biocompatibility in addition to significant antibacterial activity against Escherichia coli (99%) and Staphylococcus aureus (98%). We believe that the as-synthesized AHS have the potential to broaden the arsenal of more effective wound healing processes along with antibacterial activities.</p>
10aantibacterial activity10aBiomass10ahydrogel scaffold10amicroalgae10awound Healing1 aAgarwal, Aakanksha1 aKumar, Arun1 aGarg, Piyush1 aChakraborty, Arnab1 aVerma, Ranjan1 aSarwat, Maryam1 aGupta, Ajay1 aSasmal, Pijus, K.1 aVerma, Yogesh, Kumar1 aChowdhury, Chiranjit1 aMukherjee, Monalisa  uhttps://library.ncl.res.in/content/algal-biomass-loaded-hydrogel-scaffolds-biomimetic-platform-antibacterial-and-wound-healing