01153nas a2200253   4500008004100000022001400041245007400055210006900129260010600198300001400304490000700318520025700325653001400582653002300596653003700619653001800656653001900674653002300693100001900716700001900735700001900754700002600773856010000799       2005                        eng d  a0040-403900aCarbohydrate-based approach for the total synthesis of strictifolione0 aCarbohydratebased approach for the total synthesis of strictifol  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a4073-40750 v463 a<p>A chiral pool approach starting with D-glucose, using the Yamaguchi protocol and a Z-selective HWE reaction followed by lactonization, has been applied to execute the total synthesis of strictifolione. (c) 2005 Elsevier Ltd. All rights reserved.</p>10aD-Glucose10adouble elimination10aHorner-Wadsworth-Emmons reaction10alactonization10astrictifolione10aYamaguchi protocol1 aRamana, C., V.1 aRaghupathi, N.1 aGurjar, M., K.1 aChorghade, Mukund, S.  uhttps://library.ncl.res.in/content/carbohydrate-based-approach-total-synthesis-strictifolione-001084nas a2200241   4500008004100000022001400041245007200055210006900127260010600196300001400302490000700316520021500323653002000538653001300558653002200571653003400593653002100627100001900648700002400667700002600691700002300717856010200740       2007                        eng d  a0040-403900aCarbohydrate based approach towards the synthesis of aspercyclide C0 aCarbohydrate based approach towards the synthesis of aspercyclid  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a7524-75270 v483 a<p>A formal total synthesis of aspercyclide C (3) is described in which D-ribose is employed as a chiral pool material. The key step is a ring closing metathesis. (C) 2007 Elsevier Ltd. All rights reserved.</p>10achiron approach10aD-ribose10aMukaiyama reagent10aring closing metathesis (RCM)10aUllmann coupling1 aRamana, C., V.1 aMondal, Mohabul, A.1 aPuranik, Vedavati, G.1 aGurjar, Mukund, K.  uhttps://library.ncl.res.in/content/carbohydrate-based-approach-towards-synthesis-aspercyclide-c-001129nas a2200229   4500008004100000022001400041245009100055210006900146260010600215300001400321490000700335520024600342653001800588653002300606653002800629653003700657653002200694100001900716700002400735700002300759856011700782       2007                        eng d  a0040-403900aCentral core of uprolides D and E: a survey of some ring closing metathesis approaches0 aCentral core of uprolides D and E a survey of some ring closing   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a1013-10160 v483 a<p>A preliminary study dealing with the feasibility of ring closing metathesis and ene-yne ring closing metathesis to construct the central bicyclic cores of uprolides D and E was investigated. (c) 2006 Elsevier Ltd. All rights reserved.</p>10acembranolides10aene-yne metathesis10aRing closing metathesis10aSharpless asymmetric epoxidation10auprolides D and E1 aRamana, C., V.1 aSalian, Sumanth, R.1 aGurjar, Mukund, K.  uhttps://library.ncl.res.in/content/central-core-uprolides-d-and-e-survey-some-ring-closing-metathesis-approaches01086nas a2200157   4500008004100000022001400041245009300055210006900148260007100217300001400288490000700302520045900309100001900768700002200787856011900809       2008                        eng d  a0022-326300aCarbohydrate-based approach for the total synthesis of aculeatin D and 6-epi-aculeatin D0 aCarbohydratebased approach for the total synthesis of aculeatin   a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY  a3915-39180 v733 a<p>A concise approach for the total synthesis of aculeatin D and 6-epi-aculeatin D employing differentially protected anti,anti-1,3,5-triol alkyne prepared from alpha-D-glucoheptonic-gamma-lactone derivative is documented. Phenol protecting group manipulation for selective O-debenzylation during the hydrogenation of the diyne intermediate and one-pot phenolic oxidation with concomitant spiroketalization highlight the accomplished total synthesis.</p>1 aRamana, C., V.1 aSrinivas, Burgula  uhttps://library.ncl.res.in/content/carbohydrate-based-approach-total-synthesis-aculeatin-d-and-6-epi-aculeatin-d-001401nas a2200253   4500008004100000022001400041245009700055210006900152260010600221300001400327490000700341520044000348653001700788653002100805653002300826653002100849653002500870100001900895700002900914700002600943700002300969700003000992856012501022       2008                        eng d  a0040-403900aC-glycosides of dodecanoic acid: new capping/reducing agents for glyconanoparticle synthesis0 aCglycosides of dodecanoic acid new cappingreducing agents for gl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT  a6227-62300 v493 a<p>A concise synthesis of 12-C-glycosylated dodecanoic acids employing an olefin cross-metathesis reaction is developed. Examination of these acids as capping agents for the synthesis of metal nanoparticles reveals that they do not cap the Co-metal nanoparticles synthesized in aqueous phase, but that two of them can reduce and cap the Ag nanoparticles in water without any aggregation. (C) 2008 Elsevier Ltd. All rights reserved.</p>10aC-Glycosides10aCross metathesis10aglyconanoparticles10aGrubbs' catalyst10asilver nanoparticles1 aRamana, C., V.1 aDurugkar, Kulbhushan, A.1 aPuranik, Vedavati, G.1 aNarute, Sachin, B.1 aPrasad, Bhagavatula L. V.  uhttps://library.ncl.res.in/content/c-glycosides-dodecanoic-acid-new-cappingreducing-agents-glyconanoparticle-synthesis-001258nas a2200181   4500008004100000022001400041245013700055210006900192260011000261300001200371490000700383520046000390100001900850700002500869700002900894700002400923856012900947       2009                        eng d  a1466-803300aClick synthesis of isomeric compounds for assessing the efficiency of the bifurcated Br center dot center dot center dot NO2 synthon0 aClick synthesis of isomeric compounds for assessing the efficien  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT  a143-1500 v113 a<p>We report herein the extention of the azide-alkyne ``click reaction'' to crystal engineering and synthesize a collection of isomeric compounds with modular positioning of Br and NO2 on a tricyclic template and crystal structural analyses of the derived isomers. It is quite remarkable to notice that none of the isomers displayed the bifurcated three-center NO2 center dot center dot center dot Br supramolecular synthon in their crystal structures</p>1 aRamana, C., V.1 aChatterjee, Soumitra1 aDurugkar, Kulbhushan, A.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/click-synthesis-isomeric-compounds-assessing-efficiency-bifurcated-br-center-dot-center-001140nas a2200169   4500008004100000022001400041245007200055210006500127260010600192300001400298490000700312520047700319100002900796700002400825700001900849856010200868       2009                        eng d  a0040-402000aCu(I)-promoted one-pot `SNAr-click reaction' of fluoronitrobenzenes0 aCuIpromoted onepot SNArclick reaction of fluoronitrobenzenes  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY  a3974-39790 v653 a<p>A one-pot two-step sequence involving a nucleophilic aromatic substitution (SNAF) of activated fluorobenzenes with azide nucleophile and in situ Huisgen cycloaddition of the resulting aryl azides with alkynes has been developed for a rapid access to 1,4-substituted triazoles. Control experiments revealed that both the steps are catalyzed by Cu(I) and also the course of reaction as SNAr followed by [3+2]-cycloaddition. (C) 2009 Elsevier Ltd. All rights reserved.</p>1 aDurugkar, Kulbhushan, A.1 aGonnade, Rajesh, G.1 aRamana, C., V.  uhttps://library.ncl.res.in/content/cui-promoted-one-pot-snar-click-reaction-fluoronitrobenzenes-001868nas a2200205   4500008004100000022001400041245010300055210006900158260011000227300001200337490000700349520105000356100002301406700002001429700002101449700001901470700003001489700002101519856012201540       2010                        eng d  a1463-926200aContinuous flow synthesis of functionalized silver nanoparticles using bifunctional biosurfactants0 aContinuous flow synthesis of functionalized silver nanoparticles  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a609-6150 v123 a<p>Silver nanoparticles were synthesized by continuous flow methods using biosurfactants, namely, oleic acid sophorolipid (OASL) and stearic acid sophorolipid (SASL). Both the sophorolipids can act as reducing and capping agents. The effect of temperature on the completion of nanoparticle formation and the particle growth dynamics (size) were studied in batch mode. While the completion of the reaction using oleic acid sophorolipid needed 20 min, only 5 min were required with the stearic acid sophorolipid as capping and reducing agent. Hence all the continuous flow experiments were carried out using the stearic acid sophorolipid. The continuous flow synthesis of silver nanoparticles was carried out in a stainless steel helical coil and also in a spiral polymeric minichannel reactor. The DLS results show that higher flow rate leads to the formation of bigger and polydisperse particles because of incomplete reactions. Higher residence time allowed the completion of reaction leading to spherical, small and monodisperse particles.</p>1 aKumar, D., V. Ravi1 aKasture, Manasi1 aPrabhune, Asmita1 aRamana, C., V.1 aPrasad, Bhagavatula L. V.1 aKulkarni, A., A.  uhttps://library.ncl.res.in/content/continuous-flow-synthesis-functionalized-silver-nanoparticles-using-bifunctional-001430nas a2200217   4500008004100000022001400041245018000055210006900235260010600304300001400410490000700424520051300431653001300944653002000957653003400977653001801011653001401029100001901043700001901062856013101081       2010                        eng d  a0040-402000a [Cu]-Catalyzed S(N)AR reactions: direct amination of electron deficient aryl halides with sodium azide and the synthesis of arylthioethers under Cu(II)-ascorbate redox system0 aCuCatalyzed SNAR reactions direct amination of electron deficien  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a7642-76500 v663 a<p>A one pot [Cu]-promoted SNAr reaction of electron-deficient halobenzenes with sodium azide and the reduction of the intermediate aryl azides under the same Cu(II) ascorbate redox conditions leading to anilines has been documented. Control experiments revealed that both ascorbate and proline play important role in the reaction path way. Further, the use of this catalytic Cu(II) ascorbate redox system has been explored for the synthesis of arylthioethers. (C) 2010 Elsevier Ltd. All rights reserved.</p>10aAnilines10aAzide reduction10aCu(II)-ascorbate redox system10aSNAr reaction10aThioether1 aGoriya, Yogesh1 aRamana, C., V.  uhttps://library.ncl.res.in/content/cu-catalyzed-snar-reactions-direct-amination-electron-deficient-aryl-halides-sodium-azide-001597nas a2200205   4500008004100000022001400041245010300055210006900158260011000227300001200337490000700349520078500356100001801141700002301159700002101182700001901203700001701222700003001239856012201269       2010                        eng d  a1144-054600aCytotoxic and genotoxic assessment of glycolipid-reduced and -capped gold and silver nanoparticles0 aCytotoxic and genotoxic assessment of glycolipidreduced and capp  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a294-3010 v343 a<p>A systematic cytotoxic and genotoxic evaluation of glycolipid-conjugated silver and gold nanoparticles is carried out. These glycolipid nanoparticle conjugates are obtained by exploiting the reductive capability of a class of glycolipids called sophorolipids that play the role of capping agent as well. Further, when tested for their cytotoxicity and genotoxicity on HepG2 cells, these nanoparticles are found to be cytocompatible up to 100 mu M metal concentrations. Of the two metallic systems investigated, gold nanoparticles are found to be more cytocompatible than the same concentrations of silver nanoparticles. Similarly, it is also demonstrated that at 100 mu M, silver nanoparticles cause more DNA damage compared to gold nanoparticles of similar concentrations.</p>1 aSingh, Sanjay1 aD'Britto, Virginia1 aPrabhune, Asmita1 aRamana, C., V.1 aDhawan, Alok1 aPrasad, Bhagavatula L. V.  uhttps://library.ncl.res.in/content/cytotoxic-and-genotoxic-assessment-glycolipid-reduced-and-capped-gold-and-silver-0