01368nas a2200181   4500008004100000022001400041245011500055210006900170260010600239300001400345490000700359520059900366100002600965700002300991700002601014700001901040856012701059       2008                        eng d  a0040-402000aFacile air-oxidation of N-homopiperonyl-5,6-dimethoxyhomophthalimide: simple and efficient access to nuevamine0 aFacile airoxidation of Nhomopiperonyl56dimethoxyhomophthalimide   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a1786-17910 v643 a<p>A facile six-step synthesis of naturally occurring (+/-)-nuevamine with 55% overall yield has been described, starting from methyl 2-(6-formyl-2,3-dimethoxyphenyl)acetate via the quantitative benzylic air-oxidation of the corresponding N-homopiperonyl-5,6-dimethoxy-homophthalimide to N-homopiperonyl-5,6-dimethoxyisoquinoline-1,3,4-trione as the key reaction, followed by base catalyzed regioselective alcoholysis of the trione with ring contraction, acid catalyzed dehydrative ring closure of the formed lactamol and decarboxylation pathway. (C) 2007 Elsevier Ltd. All rights reserved.</p>1 aWakchaure, Prasad, B.1 aEaswar, Srinivasan1 aPuranik, Vedavati, G.1 aArgade, N., P.  uhttps://library.ncl.res.in/content/facile-air-oxidation-n-homopiperonyl-56-dimethoxyhomophthalimide-simple-and-efficient-001630nas a2200217   4500008004100000022001400041245005700055210005700112260007500169300001400244520088800258653001601146653001801162653002701180653002401207653002601231100002601257700002301283700001901306856008701325       2009                        eng d  a0039-788100aSynthesis of the reported protoberberine gusanlung D0 aSynthesis of the reported protoberberine gusanlung D  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcMAY  a1667-16723 a<p>Starting from homopiperonylamine or phenethylamine with homophthalic anhydride or 3,4-methylenedioxyhomophthalic acid, respectively, facile syntheses of the reported structures of (+/-)-gusanlung D and (+/-)-isogusanlung d were accomplished via regioselective reductive dehydration of the corresponding homophthalimides followed by an intramolecular acid-catalyzed or radical cyclization pathway. Starting from the corresponding suitably ortho-halogenated homophthalimides, the syntheses of dehydrogusanlung and dehydroisogusanhing D were completed via regioselective reductive dehydration followed by an intramolecular Heck coupling reaction as the key steps. The analytical and spectral data obtained for all four synthetic compounds differed from the reported data for natural gusanling D, and therefore the structural assignment of the natural product needs to be revised.</p>10agusanlung D10aHeck reaction10ahomophthalic anhydride10ahomopiperonyl amine10areductive dehydration1 aWakchaure, Prasad, B.1 aEaswar, Srinivasan1 aArgade, N., P.  uhttps://library.ncl.res.in/content/synthesis-reported-protoberberine-gusanlung-d-0