00627nas a2200133 4500008004100000022001400041245009600055210006900151260010400220300001200324490000600336100003200342856011900374 2008 eng d a1741-427X00aSecond world ayurveda congress (Theme: Ayurveda for the Future) inaugural address: part III0 aSecond world ayurveda congress Theme Ayurveda for the Future ina a410 PARK AVENUE, 15TH FLOOR, \#287 PMB, NEW YORK, NY 10022 USAbHINDAWI PUBLISHING CORPORATIONcDEC a367-3690 v51 aMashelkar, Raghunath, Anant uhttps://library.ncl.res.in/content/second-world-ayurveda-congress-theme-ayurveda-future-inaugural-address-part-iii00597nas a2200133 4500008004100000022001400041245009700055210006900152260007200221300001200293490000600305100003200311856012000343 2008 eng d a1741-427X00aSecond world ayurveda congress (Theme: Ayurveda for the Future) - inaugural address: part II0 aSecond world ayurveda congress Theme Ayurveda for the Future ina aGREAT CLARENDON ST, OXFORD OX2 6DP, ENGLANDbOXFORD UNIV PRESScSEP a243-2450 v51 aMashelkar, Raghunath, Anant uhttps://library.ncl.res.in/content/second-world-ayurveda-congress-theme-ayurveda-future-inaugural-address-part-ii-000627nas a2200133 4500008004100000022001400041245009600055210006900151260010400220300001200324490000600336100003200342856011900374 2008 eng d a1741-427X00aSecond world ayurveda congress (Theme: Ayurveda for the Future) - inaugural address: part I0 aSecond world ayurveda congress Theme Ayurveda for the Future ina a410 PARK AVENUE, 15TH FLOOR, \#287 PMB, NEW YORK, NY 10022 USAbHINDAWI PUBLISHING CORPORATIONcJUN a129-1310 v51 aMashelkar, Raghunath, Anant uhttps://library.ncl.res.in/content/second-world-ayurveda-congress-theme-ayurveda-future-inaugural-address-part-i-002288nas a2200181 4500008004100000022001400041245011900055210006900174260007100243300001400314490000700328520154400335100002401879700002101903700002301924700003201947856012701979 2009 eng d a0888-588500aSelf-similar dynamics of a flexible ring polymer in a fixed obstacle environment: a coarse-grained molecular model0 aSelfsimilar dynamics of a flexible ring polymer in a fixed obsta a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV a9514-95220 v483 a

In this contribution we concern ourselves with an interesting problem, namely, the dynamics of ideal flexible ring polymers constrained in tin array of fixed obstacles. The fundamental issue in this problem is to understand how a topologically constrained polymer chain is able to relax its conformation in the absence of chain ends. The key physics was provided in tin elegant scaling theory by Rubinstein and co-workers (Obukhov, S. P; Rubinstein, M.; Duke, T. Dynamics of a Ring Polymer in a Gel. Phys. Rev. Lett. 1994, 73, 1263-1267). In this work we develop a coarse-grained mean-field model based oil the physical arguments of the scaling theory and derive constitutive relations for rings in fixed obstacle and melt environments. The model is composed of three distinct steps. In the first step the dynamics of an arbitrary section of a ring chain is worked out based oil fractal Blob-Spring (BS) dynamics, and the center of mass diffusion and the relaxation spectrum of this section are determined. In the second step the center of mass diffusion obtained using the BS dynamics is used to model the one-dimensional diffusion of the section in a topologically constrained environment. In the final step we invoke the idea of dynamic self-similarity and argue that the dynamics described in the first and the second step, for any arbitrary section of the chain, applies to all sections of the chain. The constitutive relation is obtained consequently as the superposition of dynamic response of all sections of the ring chain.

1 aIyer, Balaji, V. S.1 aLele, Ashish, K.1 aJuvekar, Vinay, A.1 aMashelkar, Raghunath, Anant uhttps://library.ncl.res.in/content/self-similar-dynamics-flexible-ring-polymer-fixed-obstacle-environment-coarse-grained-001521nas a2200205 4500008004100000022001400041245008000055210006900135260007100204300001400275490000700289520077400296100002301070700001901093700002101112700002101133700002401154700003201178856010501210 2009 eng d a0888-588500aSome mechanistic insights into the gelation of regenerated silk fibroin sol0 aSome mechanistic insights into the gelation of regenerated silk  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcSEP a8014-80230 v483 a

We provide some new insights into the kinetics and mechanism of sol-gel transition as it pertains to regenerated silk fibroin, which is the principle structural protein of silkworm silk fiber. Silk fibroin was dissolved in lithium bromide and dialyzed against deionized water to prepare a regenerated fibroin solution. This solution was found to be unstable at lower pH and transformed into a colloidal gel. The kinetics and mechanism of the sol-gel transition were investigated using rheology and light scattering. We show that gelation proceeds in two steps. In the first step, a weak gel is formed almost immediately upon lowering the pH, while in the second step further gelation proceeds rapidly after a long induction time to form a self-similar structure.

1 aNagarkar, Shailesh1 aPatil, Avinash1 aLele, Ashish, K.1 aBhat, Suresh, K.1 aBellare, Jayesh, R.1 aMashelkar, Raghunath, Anant uhttps://library.ncl.res.in/content/some-mechanistic-insights-gelation-regenerated-silk-fibroin-sol-003180nas a2200301 4500008004100000022001400041245013900055210006900194260009800263300001400361490000700375520203500382100002502417700001702442700002202459700002302481700001902504700002902523700002202552700001902574700003102593700001802624700003202642700002102674700002702695700002502722856013102747 2013 eng d a0008-547200aSupramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy0 aSupramolecular nanoparticles that target phosphoinositide3kinase a615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USAbAMER ASSOC CANCER RESEARCHcDEC a6987-69970 v733 a

The centrality of phosphoinositide-3-kinase (PI3K) in cancer etiology is well established, but clinical translation of PI3K inhibitors has been limited by feedback signaling, suboptimal intratumoral concentration, and an insulin resistance ``class effect.'' This study was designed to explore the use of supramolecular nanochemistry for targeting PI3K to enhance antitumor efficacy and potentially overcome these limitations. PI3K inhibitor structures were rationally modified using a cholesterol-based derivative, facilitating supramolecular nanoassembly with L-alpha-phosphatidylcholine and DSPE-PEG [1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polythylen e glycol)]. The supramolecular nanoparticles (SNP) that were assembled were physicochemically characterized and functionally evaluated in vitro. Antitumor efficacy was quantified in vivo using 4T1 breast cancer and K-Ras(LSL/+)/Pten(fl/fl) ovarian cancer models, with effects on glucose homeostasis evaluated using an insulin sensitivity test. The use of PI103 and PI828 as surrogate molecules to engineer the SNPs highlighted the need to keep design principles in perspective; specifically, potency of the active molecule and the linker chemistry were critical principles for efficacy, similar to antibody-drug conjugates. We found that the SNPs exerted a temporally sustained inhibition of phosphorylation of Akt, mTOR, S6K, and 4EBP in vivo. These effects were associated with increased antitumor efficacy and survival as compared with PI103 and PI828. Efficacy was further increased by decorating the nanoparticle surface with tumor-homing peptides. Notably, the use of SNPs abrogated the insulin resistance that has been associated widely with other PI3K inhibitors. This study provides a preclinical foundation for the use of supramolecular nanochemistry to overcome current challenges associated with PI3K inhibitors, offering a paradigm for extension to other molecularly targeted therapeutics being explored for cancer treatment. (C)2013 AACR.

1 aKulkarni, Ashish, A.1 aRoy, Bhaskar1 aRao, Poornima, S.1 aWyant, Gregory, A.1 aMahmoud, Ayaat1 aRamachandran, Madhumitha1 aSengupta, Poulomi1 aGoldman, Aaron1 aKotamraju, Venkata, Ramana1 aBasu, Sudipta1 aMashelkar, Raghunath, Anant1 aRuoslahti, Erkki1 aDinulescu, Daniela, M.1 aSengupta, Shiladitya uhttps://library.ncl.res.in/content/supramolecular-nanoparticles-target-phosphoinositide-3-kinase-overcome-insulin-resistance-0