01475nas a2200181   4500008004100000022001400041245017300055210006900228260007100297300001400368490000700382520068800389100001901077700002601096700002601122700001501148856013001163       2006                        eng d  a0022-326300aConvergent approach toward the synthesis of the stereoisomers of C-6 homologues of 1-deoxynojirimycin and their analogues: evaluation as specific glycosidase inhibitors0 aConvergent approach toward the synthesis of the stereoisomers of  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcOCT  a8481-84880 v713 a<p>A new and stereoselective strategy is developed to synthesize an appropriate template 9 to obtain C-6 homologues of 1-deoxyazasugars such as 1-deoxy-D-galactohomonojirimycin ( 5), 1-deoxy-4-hydroxymethyl-D-glucohomonojirimycin (6), and their enantiomers. The template 9 is also used to obtain neutral nonbasic pseudo-glyconolactam (8), C-4 amino, and methyl analogues of 1-deoxy- homonojirimycin as new analogues of 1- deoxyhomoazasugars. Compound 5 is found to be a potent and specific inhibitor to alpha-galactosidase (K-i = 1.7 mu M). Similarly compounds 6 (K-i = 28 mu M), ent-5 (K-i = 129 mu M), and ent-6 K-i = 12 mu M) exhibited specific inhibition of beta-glucosidase.</p>1 aPandey, Ganesh1 aDumbre, Shrinivas, G.1 aKhan, Mohammad, Islam1 aShabab, M.  uhttps://library.ncl.res.in/content/convergent-approach-toward-synthesis-stereoisomers-c-6-homologues-1-deoxynojirimycin-and-001232nas a2200181   4500008004100000022001400041245015000055210006900205260010600274300001400380490000700394520043200401100002800833700002200861700001500883700002600898856012600924       2009                        eng d  a0960-894X00aClick chemistry based rapid one-pot synthesis and evaluation for protease inhibition of new tetracyclic triazole fused benzodiazepine derivatives0 aClick chemistry based rapid onepot synthesis and evaluation for   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a5241-52450 v193 a<p>We describe herein a one-pot synthesis of novel tetracyclic scaffolds that incorporate a fusion of a proline, 1,2,3-triazole ring with [1,4]-benzodiazepin-8(4H)-one ring systems following click chemistry. The expected peptide bond formation followed by in situ 1,3-dipolar cycloaddition in absence of any catalyst led to the formation of new triazole fused benzodiazepine derivatives. (C) 2009 Published by Elsevier Ltd.</p>1 aMohapatra, Debendra, K.1 aMaity, Pradip, K.1 aShabab, M.1 aKhan, Mohammad, Islam  uhttps://library.ncl.res.in/content/click-chemistry-based-rapid-one-pot-synthesis-and-evaluation-protease-inhibition-new-0