01091nas a2200157   4500008004100000022001400041245012300055210006900178260010600247300001400353490000700367520038500374100002200759700002200781856013000803       2008                        eng d  a0040-403900aCo-catalyzed mild and chemoselective reduction of phenyl esters with NaBH(4): a practical synthesis of (R)-tolterodine0 aCocatalyzed mild and chemoselective reduction of phenyl esters w  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN  a3790-37930 v493 a<p>CoCl(2) catalyzes effectively the chemoselective reduction of phenyl carboxylic esters to the corresponding saturated alcohols in high yields using NaBH(4) at ambient conditions. By employing this methodology, the synthesis of (R)-tolterodine, a muscarinic receptor antagonist, has been achieved in high yield and optical purity. (C) 2008 Elsevier Ltd. All rights reserved.</p>1 aJagdale, Arun, R.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/co-catalyzed-mild-and-chemoselective-reduction-phenyl-esters-nabh4-practical-synthesis-r-001180nas a2200217   4500008004100000022001400041245014300055210006900198260010300267300001400370490000700384520030400391653001400695653001400709653001100723653002800734100002200762700002800784700002200812856012800834       2008                        eng d  a0376-469900aCu(OTf)(2) catalyzed Biginelli type condensation of aldehydes, beta-keto esters and carbamates: synthesis of 3,4-dihydro[1,3]oxazin-2-ones0 aCuOTf2 catalyzed Biginelli type condensation of aldehydes betake  aANUSANDHAN BHAWAN, 2 RAFI MARG, NEW DELHI, 110001, INDIAbCOUNCIL SCIENTIFIC & INDUSTRIAL REScJUL  a1091-10950 v473 a<p>Cu(OTf)(2) catalyzes effectively a new multicomponent reaction comprising aldehydes, beta-ketoester and methy carbamate in acetonitrile to afford substituted 3,4-dihydro[1,3]oxazin-2-ones in 60-82% yields. These compounds have been found to show inhibition activity against HL-60 cancer cell.</p>10aaldehydes10aCatalysts10aCopper10aMulticomponent reaction1 aJagdale, Arun, R.1 aParaskar, Abhimanyu, S.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cuotf2-catalyzed-biginelli-type-condensation-aldehydes-beta-keto-esters-and-carbamates-001309nas a2200217   4500008004100000022001400041245014200055210006900197260007500266300001200341520047000353653001300823653001100836653001400847653001100861653001500872100002200887700002800909700002200937856013200959       2009                        eng d  a0039-788100aCobalt(II) chloride hexahydrate-diisopropylamine catalyzed mild and chemoselective reduction of carboxylic esters with sodium borohydride0 aCobaltII chloride hexahydratediisopropylamine catalyzed mild and  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcFEB  a660-6643 a<p>The cobalt-catalyzed reduction of unsaturated alpha-cyano carboxylic esters using sodium borohydride (NaBH(4)) leads to the corresponding saturated cyano alcohols in high yields. In particular, the new catalytic system cobalt(II) chloride-diisopropylamine in combination with NaBH(4) showed excellent activity in the chemoselective reduction of a variety of carboxylic esters to their corresponding alcohols in good to excellent yields under mild conditions.</p>10aAlcohols10aamines10acatalysis10aEsters10areductions1 aJagdale, Arun, R.1 aParaskar, Abhimanyu, S.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cobaltii-chloride-hexahydrate-diisopropylamine-catalyzed-mild-and-chemoselective-reduction-001123nas a2200169   4500008004100000022001400041245013200055210006900187260010600256300001200362490000700374520037500381100002200756700002000778700002300798856013200821       2009                        eng d  a0957-416600aConcise enantioselective synthesis of 1-[(S)-3-(dimethylamino)-3,4 dihydro-6,7-dimethoxyquinolin-1(2H)-yl]propan-1-one, (S)-9030 aConcise enantioselective synthesis of 1S3dimethylamino34 dihydro  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a335-3390 v203 a<p>A concise enantioselective synthesis of (S)-903, an inotropic agent, is described in nine linear steps and 95% ee based on asymmetric dihydroxylation of cinnamate ester and Co-catalyzed Multifunctional reduction of several functional groups leading to the construction of core tetrahydroquinolin-3-ol, as the key steps. (C) 2009 Elsevier Ltd. All rights reserved.</p>1 aJagdale, Arun, R.1 aReddy, Santhosh1 aSudalai, Arurnugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-1-s-3-dimethylamino-34-dihydro-67-dimethoxyquinolin-12h-001191nas a2200241   4500008004100000022001400041245012000055210006900175260010300244300001400347490000700361520029300368653001600661653001300677653001700690653001600707653001100723653001500734100002200749700003200771700002200803856012400825       2009                        eng d  a0376-469900aCu(OTf)(2)-catalyzed alpha-halogenation of ketones with 1,3-dichloro-5,5 `-dimethylhydantoin and N-bromosuccinimide0 aCuOTf2catalyzed alphahalogenation of ketones with 13dichloro55 d  aANUSANDHAN BHAWAN, 2 RAFI MARG, NEW DELHI, 110001, INDIAbCOUNCIL SCIENTIFIC & INDUSTRIAL REScOCT  a1424-14300 v483 a<p>Copper(II) triflate catalyses efficiently the alpha-halogentation of aryl or alkyl ketones with 1,3-dichloro-5,5'-dimethyl-hydantoin and N-bromosaccinimde to give the corresponding alpha,alpha-dichloroketones and alpha-bromoketones in high yield with excellent product selectivity.</p>10aBromination10aCatalyst10achlorination10acopper (II)10aKetone10aLewis acid1 aJagdale, Arun, R.1 aChouthaiwale, Pandurang, V.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/cuotf2-catalyzed-alpha-halogenation-ketones-13-dichloro-55-dimethylhydantoin-and-n-0