01875nas a2200241   4500008004100000022001400041245013700055210006900192260007300261300001200334490000700346520092200353653002801275653002501303653002201328653003101350653002401381100002301405700002001428700002301448700003001471856013201501       2009                        eng d  a0927-776500aIn situ synthesis of water dispersible bovine serum albumin capped gold and silver nanoparticles and their cytocompatibility studies0 aIn situ synthesis of water dispersible bovine serum albumin capp  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcOCT  a224-2280 v733 a<p>A simple and convenient one step room temperature method is described for the synthesis of bovine serum albumin (BSA) capped gold and silver nanoparticles. BSA reduces silver ions to silver nanoparticles but does not directly reduce gold ions to gold nanoparticles at room temperature and varying pH conditions. However, when silver and gold ions are simultaneously added to BSA, silver ions get reduced to metallic silver first and these in turn reduce gold ions to gold nanoparticles through a galvanic exchange reaction. The so synthesized silver and gold nanoparticles are easily water dispersible and can withstand addition of salt even at high concentrations. It is shown that the capped protein retains its secondary structure and the helicity to a large extent on the nanoparticles surface and that the protein capping makes the nanoparticles cytocompatible. (C) 2009 Elsevier B.V. All rights reserved.</p>10aAg and Au nanoparticles10aBovine serum albumin10aCytocompatibility10aGalvanic exchange reaction10aReductive synthesis1 aMurawala, Priyanka1 aPhadnis, S., M.1 aBhonde, Ramesh, R.1 aPrasad, Bhagavatula L. V.  uhttps://library.ncl.res.in/content/situ-synthesis-water-dispersible-bovine-serum-albumin-capped-gold-and-silver-nanoparticles-0