02426nas a2200265   4500008004100000022001400041245013100055210006900186260005700255300001400312490000700326520142100333653001801754653004401772653003301816653001401849653003701863100001801900700002401918700002501942700002201967700001701989700002302006856013102029       2009                        eng d  a1530-993200aNovel/conceptual floating pulsatile system using high internal phase emulsion based porous material intended for chronotherapy0 aNovelconceptual floating pulsatile system using high internal ph  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcDEC  a1368-13800 v103 a<p>The aim of the present study was to design a novel/conceptual delivery system using ibuprofen, anticipated for chronotherapy in arthritis with porous material to overcome the formulation limits (multiple steps, polymers, excipients) and to optimize drug loading for a desired release profile suitable for in vitro investigations. The objective of this delivery system lies in the availability of maximum drug amount for absorption in the wee hours as recommended. Drug loading using 3(2) factorial design on porous carrier, synthesized by high internal phase emulsion technique using styrene and divinylbenzene, was done via solvent evaporation using methanol and dichloromethane. The system was evaluated in vitro for drug loading, encapsulation efficiency, and surface characterization by scanning electron, atomic force microscopy, and customized drug release study. This study examined critical parameters such as solvent volume, drug amount, and solvent polarity on investigations related to drug adsorption and release mostly favoring low-polarity solvent dichloromethane. Overall release in all batches ranged 0.98-52% in acidic medium and 71-94% in basic medium. These results exhibit uniqueness in achieving the least drug release of 0.98%, an ideal one, without using any release modifiers, making it distinct from other approaches/technologies for time and controlled release and for chronotherapy.</p>10achronotherapy10afloating pulsatile drug delivery system10ahigh internal phase emulsion10aibuprofen10amultiparticulate porous carriers1 aSher, Praveen1 aIngavle, Ganesh, C.1 aPonrathnam, Surendra1 aBenson, James, R.1 aLi, Nai-Hong1 aPawar, Atmaram, P.  uhttps://library.ncl.res.in/content/novelconceptual-floating-pulsatile-system-using-high-internal-phase-emulsion-based-porous-0