02674nas a2200253   4500008004100000022001400041245011100055210006900166260005700235300001200292490000700304520174800311653001802059653004402077653003102121653001402152653002102166100001802187700002402205700002502229700001902254700002302273856012402296       2009                        eng d  a1530-993200aModulation and optimization of drug release from uncoated low density porous carrier based delivery system0 aModulation and optimization of drug release from uncoated low de  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcJUN  a547-5580 v103 a<p>The purpose of this research work was to explore an application of uncoated porous drug carrier prepared by single-step drug adsorption for a delivery system based on integration of floating and pulsatile principles intended for chronotherapy. This objective was achieved by utilizing 3(2) factorial design, solvent volume (X (1)) and drug amount (X (2)) as selected variables, for drug adsorption using solvents, methanol, and dichloromethane (DCM), of varying polarity. Nitrogen adsorption (N(2)), scanning electron microscopy of cross-sections, and atomic force microscopy were done to study adsorption patterns and their effect on release pattern. Drug release study was customized by performing for 6 h in acidic environment to mimic gastroretention followed by basic environment akin to transit phase. Correlation between porous data from mercury and N(2) adsorption was probably studied for the first time. Observed regression analysis values for pore volume, surface area, and drug release indicated the influence of selected variables. Total release range in acidic medium was 12.77-24.57% for methanol, 8.79-15.26% for DCM, and final release of 69.45-92.23% for methanol, and 60.16-99.99% for DCM influenced by varying internal geometries was observed. Present form of drug delivery system devoid of any additives/excipients influencing drug release shows distinct behavior from other approaches/technologies in chronotherapy by (a) observing desired low drug release (8%) in acidic medium, (b) overcoming the limitations of process variables caused by multiple formulation steps and different characteristic polymers, (c) reducing time consumption due to single step process, and (d) extending as controlled/extended release.</p>10achronotherapy10afloating pulsatile drug delivery system10alow density porous carrier10apore data10asolvent polarity1 aSher, Praveen1 aIngavle, Ganesh, C.1 aPonrathnam, Surendra1 aPoddar, Pankaj1 aPawar, Atmaram, P.  uhttps://library.ncl.res.in/content/modulation-and-optimization-drug-release-uncoated-low-density-porous-carrier-based-002426nas a2200265   4500008004100000022001400041245013100055210006900186260005700255300001400312490000700326520142100333653001801754653004401772653003301816653001401849653003701863100001801900700002401918700002501942700002201967700001701989700002302006856013102029       2009                        eng d  a1530-993200aNovel/conceptual floating pulsatile system using high internal phase emulsion based porous material intended for chronotherapy0 aNovelconceptual floating pulsatile system using high internal ph  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcDEC  a1368-13800 v103 a<p>The aim of the present study was to design a novel/conceptual delivery system using ibuprofen, anticipated for chronotherapy in arthritis with porous material to overcome the formulation limits (multiple steps, polymers, excipients) and to optimize drug loading for a desired release profile suitable for in vitro investigations. The objective of this delivery system lies in the availability of maximum drug amount for absorption in the wee hours as recommended. Drug loading using 3(2) factorial design on porous carrier, synthesized by high internal phase emulsion technique using styrene and divinylbenzene, was done via solvent evaporation using methanol and dichloromethane. The system was evaluated in vitro for drug loading, encapsulation efficiency, and surface characterization by scanning electron, atomic force microscopy, and customized drug release study. This study examined critical parameters such as solvent volume, drug amount, and solvent polarity on investigations related to drug adsorption and release mostly favoring low-polarity solvent dichloromethane. Overall release in all batches ranged 0.98-52% in acidic medium and 71-94% in basic medium. These results exhibit uniqueness in achieving the least drug release of 0.98%, an ideal one, without using any release modifiers, making it distinct from other approaches/technologies for time and controlled release and for chronotherapy.</p>10achronotherapy10afloating pulsatile drug delivery system10ahigh internal phase emulsion10aibuprofen10amultiparticulate porous carriers1 aSher, Praveen1 aIngavle, Ganesh, C.1 aPonrathnam, Surendra1 aBenson, James, R.1 aLi, Nai-Hong1 aPawar, Atmaram, P.  uhttps://library.ncl.res.in/content/novelconceptual-floating-pulsatile-system-using-high-internal-phase-emulsion-based-porous-0