00866nas a2200181   4500008004100000245008800041210006900129260000800198300001400206490000700220520025200227100001900479700002100498700001700519700001700536700001700553856011400570       2006                        eng d00aConcise asymmetric route to the antibiotic macrolides patulolide A and pyrenophorin0 aConcise asymmetric route to the antibiotic macrolides patulolide  cSEP  a6623-66260 v473 aIn this letter, we describe an enantiospecific route to patulolide A and pyrenophorin through the synthesis of known protected seco acid precursors starting from commercially available (S)-ethyl lactate. (c) 2006 Elsevier Ltd. All rights reserved.1 aRao, Srinivasa1 aReddy, Srinivasa1 aMukkanti, K.1 aPal, Manojit1 aIqbal, Javed  uhttps://library.ncl.res.in/content/concise-asymmetric-route-antibiotic-macrolides-patulolide-and-pyrenophorin02381nas a2200241   4500008004100000022001400041245014100055210006900196260000900265300001600274490000700290520150900297100002701806700001801833700001801851700002501869700002101894700002801915700001901943700002701962700002101989856012902010       2023                        eng d  a0022-326300aComprehensive study on solomonamides: total synthesis, stereochemical revision, and SAR studies toward identification of simplified lead0 aComprehensive study on solomonamides total synthesis stereochemi  cDEC   a17088-171330 v883 a<p>
	Solomonamides, a pair of macrocyclic peptide natural products originating from marine sources, have garnered significant attention within the synthetic community owing to their marked anti-inflammatory efficacy and intricate molecular architectures. In this paper, we present a very detailed investigation into solomonamides, including the challenges associated with the total synthesis, the evolution of our synthetic strategies, structural reassignment, synthesis of all possible stereoisomeric macrocycles, biological assessment, structure-activity relationship (SAR) studies, etc. Within the ambit of this total synthesis, diverse strategies for macrocyclization were rigorously explored, encompassing the Friedel-Crafts acylation, cyclization involving the aniline NH2 moiety, macrolactamization utilizing Gly-NH2, and Heck macrocyclization methodologies. In addition, an array of intriguing chemical transformations were devised, including but not limited to photo-Fries rearrangement, Wacker oxidation, ligand-free Heck macrocyclization, oxidative cleavage of indole, synthesis of contiguous stereocenters via substrate/reagent-controlled protocols, and simultaneous making and breaking of olefinic moieties. The findings of this investigation revealed a structurally simplified lead compound. Remarkably, the lead compound, while possessing structural simplification in comparison to the intricate solomonamide counterparts, demonstrates equipotent in vivo anti-inflammatory efficacy.</p>
1 aJachak, Gorakhnath, R.1 aKashinath, K.1 aVasudevan, N.1 aAthawale, Paresh, R.1 aChoudhury, Rahul1 aDange, Santoshkumar, S.1 aAgarwal, Heena1 aBarthwal, Manoj, Kumar1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/comprehensive-study-solomonamides-total-synthesis-stereochemical-revision-and-sar-studies