01327nas a2200229 4500008004100000022001400041245013000055210006900185260000900254300001100263490000700274520050900281653002700790653001800817653002000835653002100855100002200876700002100898700002600919700002100945856013100966 2020 eng d a0040-403900aTotal synthesis and absolute configuration determination of Ktedonoketone, a benzenoid metabolite from Thermophilic bacterium0 aTotal synthesis and absolute configuration determination of Kted cNOV  a1525260 v613 a

The successful total synthesis of both enantiomers of ktedonoketone allowed us to decipher an unambiguous assignment of absolute configuration of the natural product. The concise synthesis highlights Wacker oxidation and aldol condensation as key steps. In addition to this, the current synthetic route is suitable to access a library of compounds on the similar skeleton as one can use readily available amino acids and Grignard reagents as variants. (C) 2020 Elsevier Ltd. All rights reserved.

10aAbsolute configuration10aKtedonoketone10aTotal synthesis10aWacker oxidation1 aDandawate, Monica1 aChoudhury, Rahul1 aKrishna, Gamidi, Rama1 aReddy, Srinivasa uhttps://library.ncl.res.in/content/total-synthesis-and-absolute-configuration-determination-ktedonoketone-benzenoid-metabolite