01698nas a2200217   4500008004100000022001400041245011300055210006900168260009500237300001200332490000800344520091200352653001201264653001201276653001301288653000901301653000901310100001301319700002401332856012401356       2010                        eng d  a0012-160600aInteraction between ataxin-2 binding protein 1 and cubitus-interruptus during wing development in drosophila0 aInteraction between ataxin2 binding protein 1 and cubitusinterru  a525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USAbACADEMIC PRESS INC ELSEVIER SCIENCEcMAY  a389-3990 v3413 a<p>Animal growth and development is dependent on reiterative use of key signaling pathways such as Hedgehog (Hh) pathway. It is widely believed that Cubitus-interruptus (Ci) mediates all functions of Hh pathway. Here we report that CG32062, the Drosophila homologue of Ataxin-2 Binding Protein 1 (dA2BP1), functions as a cofactor of Ci to specify intervein region between L3 and L4 veins of the adult wing. Specifically, Ci-mediated transactivation of knot/collier (kn) in this region of the developing wing imaginal disc is dependent on dA2BP1 function. Protein interaction studies and chromatin-immunoprecipiation experiments suggest that Ci helps dA2BP1 to bind kn promoter, which in turn may help Ci to activate kn expression. These results suggest a mechanism by which Ci may activate targets such as kn, which do not have classical Ci/Gli-binding sites. (C) 2010 Elsevier Inc. All rights reserved.</p>10aCG3206210aCollier10aHedgehog10aKnot10aSCA21 aUsha, N.1 aShashidhara, L., S.  uhttps://library.ncl.res.in/content/interaction-between-ataxin-2-binding-protein-1-and-cubitus-interruptus-during-wing-0