01663nas a2200253 4500008004100000022001400041245015600055210006900211260010300280300001200383490000700395520063000402653002501032653004301057653001701100653002901117653001901146100002701165700002201192700002001214700001801234700002801252856012901280 2013 eng d a1631-074800aDiethylamine: a smart organocatalyst in eco-safe and diastereoselective synthesis of medicinally privileged 2-amino-4H-chromenes at ambient temperature0 aDiethylamine a smart organocatalyst in ecosafe and diastereosele a23 RUE LINOIS, 75724 PARIS, FRANCEbELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERcAUG a689-6950 v163 a

Diethylamine has been demonstrated to be an efficient organocatalyst in the diastereoselective synthesis of Bcl-2 protein antagonist (HA-14-1) and of its structural analogues by one-pot condensation between salicylaldehyde and three different C-H acids, viz, ethyl cyanoacetate, phenylsulfonyl acetonitrile, and malononitrile. Easy commercial availability of the catalyst at extremely low cost and avoidance of conventional work-up as well as purification procedures qualifies this scalable protocol for a ``near-ideal synthesis''. (c) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

10a2-amino-4H-chromenes10aActive methylene compounds (C-H acids)10adiethylamine10amulticomponent reactions10aorganocatalyst1 aKulkarni, Makarand, A.1 aPandit, Kapil, S.1 aDesai, Uday, V.1 aLad, Uday, P.1 aWadgaonkar, Prakash, P. uhttps://library.ncl.res.in/content/diethylamine-smart-organocatalyst-eco-safe-and-diastereoselective-synthesis-medicinally-001141nas a2200181 4500008004100000245012900041210006900170260000800239300001400247490000700261520044000268100002600708700002200734700002000756700002700776700002800803856012800831 2016 eng d00aDiethylamine-catalyzed environmentally benign synthesis of 1-oxo-hexahydroxanthenes and bis-coumarins at ambient temperature0 aDiethylaminecatalyzed environmentally benign synthesis of 1oxohe cJUL a6313-63250 v423 aAn extremely simple, economical and environmentally benign protocol has been described for one-pot synthesis of 1-oxo-hexahydroxanthenes by pseudo three-component condensation between salicylaldehydes and dimedone, cyclohexane-1,3dione or 5-methyl cyclohexane-1,3-dione using diethylamine as the catalyst. Based upon the mechanism of the reaction, the protocol has been extended towards the synthesis of tetraketones and bis-coumarins.1 aKupwade, Ravindra, V.1 aPandit, Kapil, S.1 aDesai, Uday, V.1 aKulkarni, Makarand, A.1 aWadgaonkar, Prakash, P. uhttps://library.ncl.res.in/content/diethylamine-catalyzed-environmentally-benign-synthesis-1-oxo-hexahydroxanthenes-and-bis01324nas a2200181 4500008004100000245021200041210006900253260000800322300001600330490000600346520054700352100002600899700001800925700002100943700002000964700002800984856013001012 2017 eng d00aDiethylamine Dess-Martin periodinane: an efficient catalyst-oxidant combination in a sequential, one-pot synthesis of difficult to access 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature0 aDiethylamine DessMartin periodinane an efficient catalystoxidant cAUG a38877-388830 v73 aHerein, diethylamine Dess–Martin periodinane has been demonstrated for the first time as an efficient catalyst–oxidant combination in a sequential, one-pot synthesis of medicinally privileged but difficult to access 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines via a pseudo-four component reaction between 2,6-disubstituted benzaldehydes, malononitrile, and thiols. Ambient reaction conditions, excellent yields, and total avoidance of conventional isolation as well as purification are the noteworthy merits of this developed protocol.1 aKupwade, Ravindra, V.1 aKhot, Supriya1 aKulkarni, M., A.1 aDesai, Uday, V.1 aWadgaonkar, Prakash, P. uhttps://library.ncl.res.in/content/diethylamine-dess-martin-periodinane-efficient-catalyst-oxidant-combination-sequential-one02369nas a2200157 4500008004100000245010500041210006900146260000800215300001400223490000700237520176800244100002102012700002202033700002802055856012802083 2018 eng d00aDesign, synthesis, and gas permeation properties of polyimides containing pendent imidazolium groups0 aDesign synthesis and gas permeation properties of polyimides con cAUG a1721-17290 v563 aFilm-forming polymers containing ionic groups have attracted considerable attention as emerging materials for gas separation applications. The aim of this article was to synthesize new film-forming polyimides containing imidazolium groups (PI-IMs) and establish their structure-performance relationship. In this context, a new aromatic diamine, namely, N-1-(4-aminophenyl)-N-1-(4-(2-phenyl-1H-imidazol-1-yl)phenyl)benzene-1,4-diamine (ImTPADA), was synthesized and polycondensed with three aromatic dianhydrides, namely, 4,4-(hexafluoroisopropylidene)diphthalic anhydride, 4,4-(4,4-isopropylidenediphenoxy) bis(phthalic anhydride), and 4,4-oxydiphthalic anhydride to form the corresponding polyimides containing pendent 2-phenylimidazole groups (PI-IEs). Next, PI-IMs were prepared by N-quaternization of pendent 2-phenylimidazole groups present in PI-6FDA using methyl iodide followed by anion exchange with bis(trifluoromethane)sulfonimide lithium salt (LiTf2N). PI-IEs and PI-IMs exhibited reasonably high molecular weights, amorphous nature, good solubility, and could be cast into self-standing films from their DMAc solutions. Thermogravimetric analysis showed that 10% weight loss temperature of PI-IEs and PI-IMs were in the range 545-475 degrees C and 303-306 degrees C, respectively. Gas permeability analysis of films of PI-IEs and PI-IMs was investigated by variable-volume method and it was observed that incorporation of ionic groups into PI-6FDA resulted in increased permeability while maintaining selectivity. In particular, polymer bearing Tf2N- anion exhibited high CO2 permeability (33.3 Barr) and high selectivity for CO2/CH4 (41.1) and CO2/N-2 (35.4). (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1721-17291 aShrimant, Bharat1 aKharul, Ulhas, K.1 aWadgaonkar, Prakash, P. uhttps://library.ncl.res.in/content/design-synthesis-and-gas-permeation-properties-polyimides-containing-pendent-imidazolium02437nas a2200253 4500008004100000022001400041245009100055210006900146260000900215300001200224490000700236520160100243653001701844653002001861653001701881653001501898653002001913100002501933700002301958700002101981700003002002700002802032856012302060 2019 eng d a0887-624X00aDesign and synthesis of aromatic polyesters bearing pendant clickable maleimide groups0 aDesign and synthesis of aromatic polyesters bearing pendant clic cMAR  a630-6400 v573 a

A bisphenol bearing pendant maleimide group, namely, N-maleimidoethyl-3, 3-bis(4-hydroxyphenyl)-1-isobenzopyrrolidone (PPH-MA) was synthesized starting from phenolphthalein. Aromatic (co)polyesters bearing pendant maleimide groups were synthesized from PPH-MA and aromatic diacid chlorides, namely, isophthaloyl chloride (IPC), terephthaloyl chloride (TPC), and 50:50 mol % mixture of IPC and TPC by low temperature solution polycondensation technique. Copolyesters were also synthesized by polycondensation of different molar proportions of PPH-MA and bisphenol A with IPC. Inherent viscosities and number-average molecular weights of aromatic (co)polyesters were in the range of 0.52-0.97 dL/g and 20,200-32,800 g/mol, respectively indicating formation of medium to reasonably high-molecular-weight polymers. C-13 NMR spectral analysis of copolyesters revealed the formation of random copolymers. The 10% weight loss temperature of (co)polyesters was found in the range 470-484 degrees C, indicating their good thermal stability. A selected aromatic polyester bearing pendant maleimide groups was chemically modified via thiol-maleimide Michael addition reaction with two representative thiol compounds, namely, 4-chlorothiophenol and 1-adamantanethiol to yield post-modified polymers in a quantitative manner. Additionally, it was demonstrated that polyester containing pendant maleimide groups could be used to form insoluble crosslinked gel in the presence of a multifunctional thiol crosslinker. (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 630-640

10acrosslinking10amaleimide group10amodification10apolyesters10athiol-maleimide1 aNagane, Samadhan, S.1 aKuhire, Sachin, S.1 aJadhav, Uday, A.1 aDhanmane, Sushilkumar, A.1 aWadgaonkar, Prakash, P. uhttps://library.ncl.res.in/content/design-and-synthesis-aromatic-polyesters-bearing-pendant-clickable-maleimide-groups01897nas a2200205 4500008004100000245011300041210006900154260000800223300001100231490000600242520113500248100002701383700002501410700002701435700002501462700002801487700002601515700002201541856012801563 2025 eng d00aDevelopment of reversed-phase HPLC method for purity assessment of aryl porphyrins and their metal complexes0 aDevelopment of reversedphase HPLC method for purity assessment o cMAY ae700580 v83 a

A gradient reversed-phase HPLC method was developed for in-process monitoring of the formation of aryl porphyrins and their corresponding metallo-aryl porphyrins. The method also proved effective for determining their quantitative purity. Optimal results achieving proper peak shape and separation of peaks in the chromatogram were obtained using C8 column and gradient of acetic acid-water and acetonitrile. The detector wavelength was selected for simultaneous detection of starting materials and products for in-process analysis for conversion of aryl aldehydes to corresponding tetraaryl porphyrins at 254 nm and metallo-aryl porphyrins formation from tetraaryl porphyrin at 413 nm, respectively; while the purity of products could be determined at 413 nm. The developed method is efficient, versatile, accurate, and easy to carry out and could serve as a handy tool for the reaction monitoring and determination of purity in the processes development of synthetic porphyrins and metalloporphyrins.

1 aUjagare, Ashish, Mohan1 aUzagare, Matthew, C.1 aGhogare, Bhausaheb, N.1 aGupta, Lokesh, Kumar1 aWadgaonkar, Prakash, P.1 aPatil, Vishwanath, R.1 aDonde, Kamini, J. uhttps://library.ncl.res.in/content/development-reversed-phase-hplc-method-purity-assessment-aryl-porphyrins-and-their-metal