01663nas a2200253   4500008004100000022001400041245015600055210006900211260010300280300001200383490000700395520063000402653002501032653004301057653001701100653002901117653001901146100002701165700002201192700002001214700001801234700002801252856012901280       2013                        eng d  a1631-074800aDiethylamine: a smart organocatalyst in eco-safe and diastereoselective synthesis of medicinally privileged 2-amino-4H-chromenes at ambient temperature0 aDiethylamine a smart organocatalyst in ecosafe and diastereosele  a23 RUE LINOIS, 75724 PARIS, FRANCEbELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERcAUG  a689-6950 v163 a<p>Diethylamine has been demonstrated to be an efficient organocatalyst in the diastereoselective synthesis of Bcl-2 protein antagonist (HA-14-1) and of its structural analogues by one-pot condensation between salicylaldehyde and three different C-H acids, viz, ethyl cyanoacetate, phenylsulfonyl acetonitrile, and malononitrile. Easy commercial availability of the catalyst at extremely low cost and avoidance of conventional work-up as well as purification procedures qualifies this scalable protocol for a ``near-ideal synthesis''. (c) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.</p>10a2-amino-4H-chromenes10aActive methylene compounds (C-H acids)10adiethylamine10amulticomponent reactions10aorganocatalyst1 aKulkarni, Makarand, A.1 aPandit, Kapil, S.1 aDesai, Uday, V.1 aLad, Uday, P.1 aWadgaonkar, Prakash, P.  uhttps://library.ncl.res.in/content/diethylamine-smart-organocatalyst-eco-safe-and-diastereoselective-synthesis-medicinally-001472nas a2200265   4500008004100000022001400041245015100055210006900206260009200275300001200367490000600379520044600385653002200831653001700853653002000870653002900890653001900919653001500938100002000953700002700973700002201000700002501022700002801047856013101075       2014                        eng d  a1751-825300aSimple, economical, and environmentally benign protocol for the synthesis of 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines at ambient temperature0 aSimple economical and environmentally benign protocol for the sy  a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcJUN  a228-2350 v73 a<p>A simple, economical, and environmentally benign protocol has been described for one-pot synthesis of medicinally privileged 2-amino-3,5-dicarbonitrile-6-sulfanylpyridines by three-component condensation between aldehyde, malononitrile, and thiol using diethylamine as a catalyst. Ambient temperature and avoidance of conventional work-up as well as purification procedure qualify this cost-effective protocol for ``green synthesis.''</p>10a5-dicarbonitriles10adiethylamine10agreen chemistry10amulticomponent reactions10aorganocatalyst10apyridine-31 aDesai, Uday, V.1 aKulkarni, Makarand, A.1 aPandit, Kapil, S.1 aKulkarni, Aparna, M.1 aWadgaonkar, Prakash, P.  uhttps://library.ncl.res.in/content/simple-economical-and-environmentally-benign-protocol-synthesis-2-amino-35-dicarbonitrile-601856nas a2200277   4500008004100000022001400041245017400055210006900229260007100298300001400369490000600383520075300389653004201142653004201184653001701226653002001243653002901263653001901292100002201311700002601333700002301359700002001382700002801402700002101430856012701451       2016                        eng d  a2168-048500aProblem solving and environmentally benign approach toward diversity oriented synthesis of novel 2-amino-3-phenyl (or Alkyl) sulfonyl-4H-chromenes at ambient temperature0 aProblem solving and environmentally benign approach toward diver  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUN  a3450-34640 v43 a<p>A problem solving, environmentally benign, and diversity oriented protocol has been described for multi component synthesis of medicinally privileged 2-amino-3-phenyl (or methyl) sulfonyl-4H-chromenes by one-pot, three component condensation among aldehydes, phenyl (or methyl) sulphonyl acetonitrile, and alpha-naphthol, 3-dimethylamino phenol, 4-hydroxy-N-methyl-quinoline-2-one as well as 4-hydroxycarbazole, using diethylamine as an efficient organo catalyst. The catalyst employed is commercially available, inexpensive, and nontoxic. Ambient reaction conditions, very high yields, wide scope, and avoidance of conventional isolation as well as chromatographic purification have improved the practical utility of this protocol manifold.</p>10a2-Amino-3-methylsulfonyl-4H-chromenes10a2-Amino-3-phenylsulfonyl-4H-chromenes10adiethylamine10agreen chemistry10aMulticomponent synthesis10aorganocatalyst1 aPandit, Kapil, S.1 aKupwade, Ravindra, V.1 aChavan, Pramod, V.1 aDesai, Uday, V.1 aWadgaonkar, Prakash, P.1 aKodam, Kisan, M.  uhttps://library.ncl.res.in/content/problem-solving-and-environmentally-benign-approach-toward-diversity-oriented-synthesis01505nas a2200253   4500008004100000245015300041210006900194260000800263300001600271490000700287520064100294653001700935653002000952653001400972653001000986653001300996653001501009100002001024700001701044700001601061700001801077700002801095856012801123       2018                        eng d00aErratum to: catalyst-free oxidation of sulfides to sulfoxides and diethylamine catalyzed oxidation of sulfides to sulfones using oxone as an oxidant0 aErratum to catalystfree oxidation of sulfides to sulfoxides and   cFEB  a1437–14370 v443 a<p>We describe here our journey from the failure of our attempts in controlled oxidation of sulfides to sulfoxides using an Oxone®–KBr combination to our success in the development of a catalyst-free protocol for the oxidation of sulfides to sulfoxides using Oxone as an oxidant. We also describe the failure of our attempts at the oxidation of sulfides to sulfones using an excess of Oxone–KBr as well as Oxone, and our success towards the development of a rapid, scalable and chromatography-free protocol for the oxidation of sulfides to sulfones using diethylamine–Oxone as an unprecedented catalyst–oxidant combination.</p>10adiethylamine10aorganocatalysis10aOxidation10aOxone10aSulfones10aSulfoxides1 aKupwade, R., V.1 aKhot, S., S.1 aLad, U., P.1 aDesai, U., V.1 aWadgaonkar, Prakash, P.  uhttps://library.ncl.res.in/content/erratum-catalyst-free-oxidation-sulfides-sulfoxides-and-diethylamine-catalyzed-oxidation