02335nas a2200217   4500008004100000022001400041245019500055210006900250260000800319300001100327490000800338520148600346653001701832653002101849653002901870653001601899653002301915100002101938700002301959856013501982       2023                        eng d  a0926-669000aEffective valorization of blackstrap molasses to poly gamma glutamic acid (γ-PGA) using L-glutamic acid independent feeding approach and its significance as drought mitigator in wheat plant0 aEffective valorization of blackstrap molasses to poly gamma glut  cOCT  a1169850 v2023 a<p>
	One of the finest approaches towards sustainable waste management is its effective valorization to value-added products (VAPs). Waste valorization is garnering considerable attention since it delivers substantial advantages, including environmental stability and a sustainable and viable platform for producing different VAPs. One such VAP is the poly gamma glutamic acid (&amp; gamma;- PGA), an extortionate biopolymer known to date. Its exorbitant cost is the main barrier preventing &amp; gamma;- PGA from becoming commercially viable. Hence, the key to the successful commercialization of &amp; gamma;- PGA is its sustainable and cost-effective production. In the present study, the ability of Bacillus paralicheniformis NCIM 5769 to utilize molasses for &amp; gamma;-PGA production with minimal nutrients was investigated. Results showed that 30% molasses combined with 2% ammonium nitrate was the optimal medium for &amp; gamma;-PGA production. Additionally, the anti-drought activity of the synthesized &amp; gamma;-PGA was evaluated on wheat plants showing significantly higher shoot length, biomass content, and germination rate compared to the control group. These findings suggest that &amp; gamma;-PGA produced from molasses has the potential to be used as a drought mitigator in wheat plant, thereby achieving the mission of circular economy and sustainable development goal (SGD) 12, i.e. pursuing sustainability patterns for consumption &amp; production.</p>
10aAnti-drought10acircular economy10aPoly gamma glutamic acid10aSustainable10aWaste valorization1 aNair, Pranav, G.1 aDharne, Mahesh, S.  uhttps://library.ncl.res.in/content/effective-valorization-blackstrap-molasses-poly-gamma-glutamic-acid-%CE%B3-pga-using-l-glutamic01864nas a2200193   4500008004100000022001400041245013100055210006900186260000800255520112600263653002201389653002101411653002901432653002301461100001701484700002401501700002301525856012201548       2023                        eng d  a2190-681500aPoly-gamma-glutamic acid biopolymer: a sleeping giant with diverse applications and unique opportunities for commercialization0 aPolygammaglutamic acid biopolymer a sleeping giant with diverse   cAPR3 a<p>Poly-gamma-glutamic acid (gamma-PGA) is a biodegradable, non-toxic, ecofriendly, and non-immunogenic biopolymer. Its phenomenal properties have gained immense attention in the field of regenerative medicine, the food industry, wastewater treatment, and even in 3D printing bio-ink. The gamma-PGA has the potential to replace synthetic non-degradable counterparts, but the main obstacle is the high production cost and lower productivity. Extensive research has been carried out to reduce the production cost by using different waste; however, it is unable to match the commercialization needs. This review focuses on the biosynthetic mechanism of gamma-PGA, its production using the synthetic medium as well as different wastes by L-glutamic acid-dependent and independent microbial strains. Furthermore, various metabolic engineering strategies and the recovery processes for gamma-PGA and their possible applications are discussed. Finally, highlights on the challenges and unique approaches to reduce the production cost and to increase the productivity for commercialization of gamma-PGA are also summarized.</p>
10aCommercialization10aMulti-nutritious10aPoly-gamma-glutamic acid10aWaste valorization1 aNair, Pranav1 aNavale, Govinda, R.1 aDharne, Mahesh, S.  uhttps://library.ncl.res.in/content/poly-gamma-glutamic-acid-biopolymer-sleeping-giant-diverse-applications-and-unique