01616nas a2200181   4500008004100000022001400041245014000055210006900195260007200264300000900336490000700345520086300352100001801215700002401233700002201257700002601279856012901305       2007                        eng d  a0305-104800aVersatile method for the preparation of conjugates of peptides with DNA/PNA/analog by employing chemo-selective click reaction in water0 aVersatile method for the preparation of conjugates of peptides w  aGREAT CLARENDON ST, OXFORD OX2 6DP, ENGLANDbOXFORD UNIV PRESScDEC  ae1390 v353 a<p>The specific 1,3 dipolar Hisgen cycloaddition reaction known as `click-reaction' between azide and alkyne groups is employed for the synthesis of peptideoligonucleotide conjugates. The peptide nucleic acids (PNA)/DNA and peptides may be appended either by azide or alkyne groups. The cycloaddition reaction between the azide and alkyne appended substrates allows the synthesis of the desired conjugates in high purity and yields irrespective of the sequence and functional groups on either of the two substrates. The versatile approach could also be employed to generate the conjugates of peptides with thioacetamido nucleic acid (TANA) analog. The click reaction is catalyzed by Cu (I) in either water or in organic medium. In water, similar to 3-fold excess of the peptide-alkyne/azide drives the reaction to completion in 2 h with no side products.</p>1 aGogoi, Khirud1 aMane, Meenakshi, V.1 aKunte, Sunita, S.1 aKumar, Vaijayanti, A.  uhttps://library.ncl.res.in/content/versatile-method-preparation-conjugates-peptides-dnapnaanalog-employing-chemo-selective-000954nas a2200145   4500008004100000022001400041245012800055210006900183260011000252300001200362520025800374100001800632700002600650856013200676       2008                        eng d  a1359-734500aChimeric (alpha-amino acid plus nucleoside-beta-amino acid)(n) peptide oligomers show sequence specific DNA/RNA recognition0 aChimeric alphaamino acid plus nucleosidebetaamino acidn peptide   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN  a706-7083 a<p>An alpha/beta-peptide backbone oligonucleotide comprising natural alpha-amino acids alternating with a beta-amino acid component derived from thymidine sequence specifically recognizes and binds to deoxy- and ribo-oligoadenylates in triplex mode.</p>1 aGogoi, Khirud1 aKumar, Vaijayanti, A.  uhttps://library.ncl.res.in/content/chimeric-alpha-amino-acid-plus-nucleoside-beta-amino-acidn-peptide-oligomers-show-sequence-001528nas a2200169   4500008004100000022001400041245019800055210006900253260007100322300001400393490000700407520074700414100002401161700001801185700002601203856012901229       2010                        eng d  a0022-326300aProbing binding preferences of DNA and RNA: backbone chirality of thioacetamido-linked nucleic acids and iso-thioacetamido-linked nucleic acids to differentiate DNA versus RNA selective binding0 aProbing binding preferences of DNA and RNA backbone chirality of  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a7431-74340 v753 a<p>Subtle differences in RNA and DNA duplex geometry could be sensed by the changed stereochemistry at 3 `-amino function in the 5-atom thioacetamido linker of thioacetamido-linked nucleic acids and iso-thioacetamido-linked nucleic acids modified oligomers. In contrast to the preferred N-type sugar conformations for either 3 `- ribo- or xylo amino nucleosides, predominant S-type sugar conformations were found in the dimers. Although the CD spectral differences for the dimer blocks were found to be identical for those found in phosphodiester linked ribo/xylo dimers, the 5-atom thioactamido linker could reverse the RNA binding selectivity to DNA binding selectivity by the change in configuration at the 3 `-amino-substituted sugar.</p>1 aGokhale, Sachin, S.1 aGogoi, Khirud1 aKumar, Vaijayanti, A.  uhttps://library.ncl.res.in/content/probing-binding-preferences-dna-and-rna-backbone-chirality-thioacetamido-linked-nucleic-0