01710nas a2200217   4500008004100000022001400041245008800055210006900143260010600212300001400318490000700332520088500339653001601224653001201240653002801252653002001280653002101300100002501321700002401346856012201370       2010                        eng d  a0040-402000aBase dependent pyrrolidine ring pucker in aep-PNA monomers NMR and PSEUROT analysis0 aBase dependent pyrrolidine ring pucker in aepPNA monomers NMR an  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a9165-91700 v663 a<p>The aep-PNA is a chiral and cyclic PNA analogue which has a stronger and base dependent binding affinity with complementary DNA To understand the base dependent properties at monomer level the structural studies of aep-PNA-(T/C/A) monomers have been carried out focussing on the conformational analysis of pyrrolidine ring pucker in aep-PNA by H-1 NMR and the coupling constant data fitted into PSEUROT software The results indicate that the type of pyrrolidine pucker depends on the electronic nature of substituent implying the effect of pyrimidine or purine substituents in determining the ring pucker in monomers This may consequently influence the aep-PNA oligomer conformation Since pyrrolidine nucleic acids have emerged as an important class of PNA analogues present results may have importance for their future development (C) 2010 Elsevier Ltd All rights reserved</p>10aA T G and C10aaep PNA10aConformational analysis10aDNA RNA and PNA10aPyrrolidine ring1 aSharma, Nagendra, K.1 aGanesh, Krishna, N.  uhttps://library.ncl.res.in/content/base-dependent-pyrrolidine-ring-pucker-aep-pna-monomers-nmr-and-pseurot-analysis-001420nas a2200157   4500008004100000022001400041245009200055210006900147260011000216300001200326490000600338520074800344100002501092700002401117856012101141       2011                        eng d  a1477-052000aEnhanced stability of G-quadruplexes from conformationally constrained aep-PNA backbone0 aEnhanced stability of Gquadruplexes from conformationally constr  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a725-7290 v93 a<p>Nucleic (DNA) acids having contiguous stretch of G sequence form quadruplex structure, which is very critical to control cell division. Recently the existence of G-quadruplex in RNA is also reported in presence of monovalent metal ion. PNA is a promising DNA analogue which binds strongly to DNA to form PNA: DNA duplex or PNA(2) : DNA triplex. PNA also forms quadruplexes such G-quadruplex and i-motif in G and C-rich sequences respectively. aep-PNA containing a prolyl ring is one of several PNA analogues that provide rigidity and chirality in backbone and has binding affinity to natural DNA which is higher than that of PNA. Here we examine the ability of aep-PNA-G to form a quadruplex by UV, CD and mass spectroscopic techniques.</p>1 aSharma, Nagendra, K.1 aGanesh, Krishna, N.  uhttps://library.ncl.res.in/content/enhanced-stability-g-quadruplexes-conformationally-constrained-aep-pna-backbone-0