01893nas a2200193   4500008004100000022001400041245011200055210006900167260011000236300001400346490000700360520110200367100002001469700002001489700001801509700002001527700002201547856013001569       2011                        eng d  a0959-942800aSynthesis and characterization of poly-L-lysine grafted SBA-15 using NCA polymerization and click chemistry0 aSynthesis and characterization of polyLlysine grafted SBA15 usin  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a6690-66970 v213 a<p>Poly-L-lysine (PLL) grafted ordered mesoporous material was prepared by a combination of NCA polymerization and click chemistry. Large pore SBA-15 with a mesopore diameter of similar to 12 nm was synthesized using a previously reported method. The surface of this SBA-15 material was modified with azidopropyl groups. This ``clickable'' SBA-15 was then reacted with an alkyne terminated poly-L-lysine synthesized by the ring-opening polymerization of 3-cbz-L-lysine NCA with N-TMS propargylamine as the initiator. This procedure allows grafting of a uniform polymer film with a high polymer loading. No appreciable pore blocking was observed upon grafting of PLL. No change in the periodic structure of the SBA-15 was observed throughout the grafting process. The SBA-15 PLL conjugate was characterized using (13)C and (29)Si NMR, XRD, FT-IR, N(2) adsorption-desorption and thermogravimetry. The results indicate that polypeptides can be easily grafted onto various ordered mesoporous materials by this ``grafting to'' methodology with accessible pores and high loadings of the polypeptide.</p>1 aKar, Mrityunjoy1 aMalvi, Bharmana1 aDas, Anindita1 aPanneri, Suyana1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/synthesis-and-characterization-poly-l-lysine-grafted-sba-15-using-nca-polymerization-and-0