02789nas a2200217 4500008004100000022001400041245014400055210006900199260007100268300001200339490000700351520192500358100002102283700002302304700002302327700002102350700002602371700002402397700002602421856012402447 2011 eng d a0020-166900aSynthesis, electronic structure, DNA and protein binding, DNA cleavage, and anticancer activity of fluorophore-labeled copper(II) complexes0 aSynthesis electronic structure DNA and protein binding DNA cleav a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJAN a545-5580 v503 a

Two mononuclear fluorophore-labeled copper(II) complexes [Cu(nip)(acac)](+) (2) and [Cu(nip)(2)](2+) (3), where fluorophore is 2-(naphthalen-1-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (nip) (1) and acac is acetylacetone, have been synthesized aid characterized by various techniques. The ligand 1 and complex 2 are structurally characterized by single-crystal X-ray diffraction. The coordination geometries around the copper are square planar in solid as well as solution state as evidenced by electron paramagnetic resonance (EPR) spectroscopy. The density functional calculations carried out on 1-3 have shown that electron-rich regions in the highest occupied orbital are localized on the naphthalene end partly on the phenanthroline moiety. Both complexes 2 and 3 in dimethyl sulfoxide (DMSO) exhibit near square planar structure around the metal ion in their ground state. Time-dependent density functional theory (TD-DFT) calculations reveal that Cu(II) ion in complex 2 shows tetrahedral coordination around the metal while 3 retains its square planar geometry in the lowest excited state. The interaction of complexes with calf-thymus DNA (CT DNA) has been explored by using absorption, emission, thermal denaturation, and viscosity studies, and the intercalating mode of DNA binding has been proposed. The complexes cleave DNA oxidatively without any exogenous additives. The protein binding ability has been monitored by quenching of tryptophan emission in the presence of complexes using bovine serum albumin (BSA) as model protein. The compounds showed dynamic quenching behavior. Further, the anticancer activity of the complexes on MCF-7 (human breast cancer), HeLa (human cervical cancer), HL-60 (human promyelocytic leukemia), and MCF-12A (normal epithelial) cell lines has been studied. It has been observed that 3 exhibits higher cytotoxicity than 2, and the cells undergo apoptotic cell death.

1 aBhat, Satish, S.1 aKumbhar, Anupa, A.1 aHeptullah, Hussain1 aKhan, Ayesha, A.1 aGobre, Vivekanand, V.1 aGejji, Shridhar, P.1 aPuranik, Vedavati, G. uhttps://library.ncl.res.in/content/synthesis-electronic-structure-dna-and-protein-binding-dna-cleavage-and-anticancer-002273nas a2200229 4500008004100000022001300041245012200054210006900176260000800245300001400253490000700267520144600274100002501720700002101745700002701766700002401793700002401817700002501841700002401866700002301890856013001913 2018 eng d a1466803300aWater mediated proton conductance in a hydrogen-bonded Ni(II)-bipyridine-glycoluril chloride self-assembled framework0 aWater mediated proton conductance in a hydrogenbonded NiIIbipyri cJAN a1094-11000 v203 a

Proton conducting properties have been investigated in a new Ni(II)-based hydrogen-bonded porous framework synthesized using a urea-fused bipyridine-glycoluril (BPG) tecton. This hydrogen-bonded self-assembled structure encapsulates water molecules in the channels with hydrogen-bonding networks which exhibits a significant temperature dependent proton conductance of 1.5 × 10−4 S cm−1 at 95 °C and 95% RH with a low activation energy (Ea) of 0.54 eV, implying a Grotthuss proton hopping mechanism mediated by hydrogen-bonded water molecules in the channels. In addition, this framework exhibited a very high water uptake under humid conditions. A continuous array of water molecules and chloride ions embedded in the highly hydrophilic porous channels of the hydrogen-bonded framework acts as the proton conducting medium.

 

 

1 aTayade, Sakharam, B.1 aBhat, Satish, S.1 aIllathvalappil, Rajith1 aDhavale, Vishal, M.1 aKawade, Vitthal, A.1 aKumbhar, Avinash, S.1 aKurungot, Sreekumar1 aNäther, Christian uhttps://library.ncl.res.in/content/water-mediated-proton-conductance-hydrogen-bonded-niii-bipyridine-glycoluril-chloride-self01220nas a2200301 4500008004100000022001400041245015700055210006900212260000800281300001100289490000800300520020800308653002300516653001700539653001700556653001600573653001400589100002100603700002500624700002300649700001700672700001900689700002100708700002600729700001700755700001700772856012900789 2020 eng d a0162-013400aTris-heteroleptic ruthenium(II) polypyridyl complexes: Synthesis, structural characterization, photophysical, electrochemistry and biological properties0 aTrisheteroleptic rutheniumII polypyridyl complexes Synthesis str cFEB a1109030 v2033 a

{Three water-soluble tris-heteroleptic ruthenium(II) polypyridyl complexes [Ru(bpy)(phen)(bpg)](2+) (1), [Ru (bpy)(dppz)(bpg)]2+ (2), and [Ru(phen)(dppz)(bpg)]2+ (3) (where bpy = 2,2'-bipyridine

10aCircular dichroism10aCytotoxicity10afluorescence10aPolypyridyl10aruthenium1 aBhat, Satish, S.1 aKumbhar, Avinash, S.1 aPurandare, Neeraja1 aKhan, Ayesha1 aGrampp, Gunter1 aLoennecke, Peter1 aHey-Hawkins, Evamarie1 aDixit, Ruchi1 aVanka, Kumar uhttps://library.ncl.res.in/content/tris-heteroleptic-rutheniumii-polypyridyl-complexes-synthesis-structural-characterization