01694nas a2200169   4500008004100000022001400041245013600055210006900191260007100260300001600331490000700347520096900354100002601323700002601349700002801375856012101403       2005                        eng d  a0022-326300aPreorganizing linear (self-complementary) quadruple hydrogen-bonding arrays using intramolecular hydrogen bonding as the sole force0 aPreorganizing linear selfcomplementary quadruple hydrogenbonding  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a10067-100720 v703 a<p>In this article we describe a rational approach for prefixing multiple cooperative binding sites in an ideal spatial arrangement on a structurally rigid backbone, constrained exclusively by intramolecular hydrogen bonding. The idea is exemplified by the ability of the self-assembling constructs la-e and 2a,b to form hydrogen-bonded dimers, whose structural preorganization has been solely effected by intramolecular hydrogen bonding. The readily accessible amidinourea backbone has been used as a common platform for the construction of a variety of such self-assembling systems. ESI mass spectrometry and single-crystal X-ray diffraction studies have been particularly effective in investigating the self-assembling propensities of these systems. Remarkably, most the H-bonded dimers reported herein undergo an unusual mode of self-assembly, using intermolecular four-membered ring hydrogen-bonded interaction, affording extended supramolecular networks.</p>1 aPrabhakaran, Panchami1 aPuranik, Vedavati, G.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/preorganizing-linear-self-complementary-quadruple-hydrogen-bonding-arrays-using-001473nas a2200253   4500008004100000022001400041245011900055210006900174260007700243300001400320520056200334653001100896653001100907653002300918653001100941653002000952653001300972100002400985700002001009700002601029700002101055700001501076856012801091       2005                        eng d  a1434-194800aPyrazole-tethered heteroditopic ligands and their transition metal complexes: synthesis, structure, and reactivity0 aPyrazoletethered heteroditopic ligands and their transition meta  aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcAPR  a1254-12633 a<p>Various pyrazole-based PN (2a-c) and N,N (3a-b) ligands have been synthesized. Using representative ligands, Ni-II, Co-II, Cu-II, and Cu-I complexes have been prepared and structurally characterized by crystallography. During complexation of Co-II and Cu-II salts, the phosphane part of the PN ligand oxidized to phosphane oxide. For N,N donor ligands, a dimeric chloro-bridged Ni-III complex was obtained. Ni-II complex 4 is an active catalyst for ethylene oligomerization. ((c) Wiley-VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheirn, Germany, 2005).</p>10acobalt10aCopper10ahemilabile ligands10aNickel10aoligomerization10aPyrazole1 aMukherjee, Anuradha1 aSubramanyam, U.1 aPuranik, Vedavati, G.1 aMohandas, T., P.1 aSarkar, A.  uhttps://library.ncl.res.in/content/pyrazole-tethered-heteroditopic-ligands-and-their-transition-metal-complexes-synthesis-001272nas a2200217   4500008004100000022001400041245007500055210006700130260007500197300001400272520050900286653001900795653001700814653001600831653001200847653001400859100002400873700002600897700003100923856010000954       2007                        eng d  a0039-788100aPractical formal synthesis of D-(+)-biotin from 4-formylazetidin-2-one0 aPractical formal synthesis of Dbiotin from 4formylazetidin2one  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcAPR  a1159-11643 a<p>A practical synthesis of (3S,6R)-1,3-dibenzyltetrahydro-1H-furo[3,4-d]imidazole-2,4-dione, an important intermediate in the synthesis of biotin, from 4-formyl-3-mesyloxyazetidin-2-one has been achieved. Acid-catalyzed azetidin-2-one ring opening followed by a one-pot conversion of diamine hydrochloride to a cyclic urea and hydroxymethylene to chloromethylene by triphosgene to obtain (4S,5R)-methyl-1,3-dibenzyl-5-chloromethyl-2-oxoimidazolidine-4-carboxyl ate is the key step in this synthesis.</p>10aazetidin-2-one10abeta-Lactams10acyclization10aLactone10areduction1 aKale, Ajaykumar, S.1 aPuranik, Vedavati, G.1 aDeshmukh, Abdul, Rakeeb A.  uhttps://library.ncl.res.in/content/practical-formal-synthesis-d-biotin-4-formylazetidin-2-one-102521nas a2200277   4500008004100000022001400041245012800055210006900183260007300252300001200325490000700337520149500344653003001839653002601869653002401895653001901919100002001938700002801958700001401986700001702000700002602017700002102043700003102064700002002095856012802115       2008                        eng d  a0924-857900aPotential plasmid-curing agent, 8-epidiosbulbin E acetate, from dioscorea bulbifera L. against multidrug-resistant bacteria0 aPotential plasmidcuring agent 8epidiosbulbin E acetate from dios  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcNOV  a405-4100 v323 a<p>Bioassay-guided fractionation of an aqueous methanolic extract of Dioscorea bulbifera L. bulbs was performed using organic solvents. A novel plasmid-curing compound was identified as 8-epidiosbulbin E acetate (EEA) (norditerpene) on the basis of modern spectroscopic analysis and X-ray crystallography. EEA exhibited broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. EEA cured antibiotic resistance plasmids (R-plasmids) from clinical isolates of Enterococcus faecalis, Escherichia coli, Shigella sonnei and Pseudomonas aeruginosa with 12-48% curing efficiency. The reference plasmids of Bacillus subtilis (pUB110), E. coli (RP4), P. aeruginosa (RIP64) and Salmonella typhi (R136) were cured with efficiency ranging from 16% to 64%. EEA-mediated R-plasmid curing decreased the minimal inhibitory concentration of antibiotics against MDR bacteria, thus making antibiotic treatment more effective. The antibiotic resistance pattern revealed that the compound was effective in the reversal of bacterial resistance to various antibiotics. In addition, the compound did not show any cytotoxicity against a broad range of human cancer cell lines, namely MCF-7 (breast cancer), SiHa (cervical cancer) and A431 (epidermal carcinoma), and hence has the potential to be used as a lead compound for drug discovery programmes. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.</p>10a8-Epidiosbulbin E acetate10aAntibiotic resistance10aDioscorea bulbifera10aPlasmid curing1 aShriram, Varsha1 aJahagirdar, Sheetal, S.1 aLatha, C.1 aKumar, Vinay1 aPuranik, Vedavati, G.1 aRojatkar, Supada1 aDhakephalkar, Prashant, K.1 aShitole, M., G.  uhttps://library.ncl.res.in/content/potential-plasmid-curing-agent-8-epidiosbulbin-e-acetate-dioscorea-bulbifera-l-against-001056nas a2200205   4500008004100000022001400041245005300055210005300108260007600161300001000237490000700247520036000254100002300614700002500637700002300662700002500685700002600710700002700736856008700763       2011                        eng d  a0018-019X00aPhytochemical investigation of artemisia pallens0 aPhytochemical investigation of artemisia pallens  aCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAbWILEY-BLACKWELLcJAN  a73-770 v943 a<p>Two new eudesmanolides, pallensin (1) and 4-epipallensin (2), along with a known eudesmanolide, santonin, and a known flavone, 4-epivalgarin, have been isolated from the aerial part of A. pallens. Their structures were established by detailed spectral studies (1D and 2D) and by comparison of their spectroscopic data with those of known compounds.</p>1 aRuikar, Anjali, D.1 aJadhav, Ravindra, B.1 aPhalgune, Usha, D.1 aRojatkar, Supada, R.1 aPuranik, Vedavati, G.1 aDeshpande, Nirmala, R.  uhttps://library.ncl.res.in/content/phytochemical-investigation-artemisia-pallens-001774nas a2200253   4500008004100000022001400041245005400055210005400109260009200163300001400255490000700269520092500276653002401201653001401225653003101239653002901270100002501299700002101324700002301345700001901368700002601387700002101413856008601434       2012                        eng d  a1028-602000aPhyllocladane diterpenes from anisomeles heyneana0 aPhyllocladane diterpenes from anisomeles heyneana  a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcNOV  a1162-11680 v143 a<p>New phyllocladane diterpene, phyllocladan-16 alpha,17-dihydroxy-19-oic acid (1), together with known phyllocladane diterpene, phyllocladan-16 alpha,19-diol (2), cembrane diterpene ovatodiolide (3), sitosteryl-3-O-beta-D-glucoside (4), and verbascoside (5), were isolated from aerial parts of Anisomeles heyneana. The structure of compound 1 was elucidated by 1D and 2D NMR analyses which included HSQC, HMBC, and nuclear overhauser effect spectroscopy (NOESY) experiments as well as X-ray crystallography. This is the first report of phyllocladane diterpenes from genus Anisomeles. Compounds 1, 3, 4, and 5 were evaluated for inhibition of Mycobacterium tuberculosis and 3 was found to exhibit anti-mycobacterial activity with IC90 6.53 mu g/ml. Compounds 1, 3, and 5, at 100 mu g/ml, were also evaluated for inhibition of Thp-1 cell lines, and compounds 1 and 3 showed 59.02% and 96.4% inhibitions, respectively.</p>10aAnisomeles heyneana10aLamiaceae10aMycobacterium tuberculosis10aphyllocladane diterpenes1 aKulkarni, Roshan, R.1 aShurpali, Ketaki1 aGawade, Rupesh, L.1 aSarkar, Dhiman1 aPuranik, Vedavati, G.1 aJoshi, Swati, P.  uhttps://library.ncl.res.in/content/phyllocladane-diterpenes-anisomeles-heyneana-001445nas a2200205   4500008004100000022001400041245009200055210006900147260011000216300001600326490000600342520063800348100001400986700002201000700002301022700002601045700002401071700002801095856011601123       2014                        eng d  a2046-206900aProbing the folding induction ability of orthanilic acid in peptides: some observations0 aProbing the folding induction ability of orthanilic acid in pept  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN  a13018-130250 v43 a<p>This paper describes the ability of orthanilic acid (2-aminobenzenesulfonic acid, (S)Ant) to promote folding when introduced in a peptide sequence. Three peptide sequences, containing orthanilic acid (SAnt) with a sulfonamide moiety in the turn segment, have been synthesized in the solution phase using suitable coupling agents, and their structural aspects investigated using NMR and X-ray crystallographic studies. Solid- and solution-state conformational analyses reveal that the peptide sequences containing orthanilic acid in their backbone exist in a folded conformation featuring long-range 15-membered ring H-bonding.</p>1 aRoy, Arup1 aKotmale, Amol, S.1 aGawade, Rupesh, L.1 aPuranik, Vedavati, G.1 aRajamohanan, P., R.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/probing-folding-induction-ability-orthanilic-acid-peptides-some-observations