01781nas a2200289   4500008004100000022001400041245012200055210006900177260007100246300001400317490000600331520076000337653002101097653001301118653003001131653001401161653001501175653001101190100002401201700002501225700002001250700002901270700001801299700002101317700002901338856012401367       2011                        eng d  a1944-824400aIsobutrin from butea monosperma (flame of the forest): a promising new natural sensitizer belonging to chalcone class0 aIsobutrin from butea monosperma flame of the forest a promising   a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUL  a2440-24440 v33 a<p>In this work, ``isobutrin'', an ecofriendly sensitizer that is extracted from Butea monosperma (commonly known as ``Flame of the Forest'') flowers, is introduced. It is a bright yellow pigment belonging to the chalcone class and is examined as a sensitizer for optoelectronic applications. It is observed that chelation of this dye with Ti ions results into a strong dye-TiO(2) charge transfer (DTCT) band in the visible region. This Ti-Isobutrin chelate is stable, irreversible and its formation is studied using Benesi-Hildebrand plot. The locations of HOMO-LUMO states of the Ti-isobutrin chelate and the corresponding band alignment with TiO(2) are obtained. Also, a thermal stability test revealed that isobutrin is stable above 100 degrees C.</p>10aButea monosperma10achalcone10adye-sensitized solar cell10aisobutrin10asensitizer10aTiO(2)1 aAgarkar, Shruti, A.1 aKulkarni, Roshan, R.1 aDhas, Vivek, V.1 aChinchansure, Ashish, A.1 aHazra, Partha1 aJoshi, Swati, P.1 aOgale, Satishchandra, B.  uhttps://library.ncl.res.in/content/isobutrin-butea-monosperma-flame-forest-promising-new-natural-sensitizer-belonging-001774nas a2200253   4500008004100000022001400041245005400055210005400109260009200163300001400255490000700269520092500276653002401201653001401225653003101239653002901270100002501299700002101324700002301345700001901368700002601387700002101413856008601434       2012                        eng d  a1028-602000aPhyllocladane diterpenes from anisomeles heyneana0 aPhyllocladane diterpenes from anisomeles heyneana  a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcNOV  a1162-11680 v143 a<p>New phyllocladane diterpene, phyllocladan-16 alpha,17-dihydroxy-19-oic acid (1), together with known phyllocladane diterpene, phyllocladan-16 alpha,19-diol (2), cembrane diterpene ovatodiolide (3), sitosteryl-3-O-beta-D-glucoside (4), and verbascoside (5), were isolated from aerial parts of Anisomeles heyneana. The structure of compound 1 was elucidated by 1D and 2D NMR analyses which included HSQC, HMBC, and nuclear overhauser effect spectroscopy (NOESY) experiments as well as X-ray crystallography. This is the first report of phyllocladane diterpenes from genus Anisomeles. Compounds 1, 3, 4, and 5 were evaluated for inhibition of Mycobacterium tuberculosis and 3 was found to exhibit anti-mycobacterial activity with IC90 6.53 mu g/ml. Compounds 1, 3, and 5, at 100 mu g/ml, were also evaluated for inhibition of Thp-1 cell lines, and compounds 1 and 3 showed 59.02% and 96.4% inhibitions, respectively.</p>10aAnisomeles heyneana10aLamiaceae10aMycobacterium tuberculosis10aphyllocladane diterpenes1 aKulkarni, Roshan, R.1 aShurpali, Ketaki1 aGawade, Rupesh, L.1 aSarkar, Dhiman1 aPuranik, Vedavati, G.1 aJoshi, Swati, P.  uhttps://library.ncl.res.in/content/phyllocladane-diterpenes-anisomeles-heyneana-001219nas a2200193   4500008004100000022001400041245006400055210006400119260007100183300001400254490000700268520054200275100002500817700002100842700002600863700001900889700002100908856009600929       2013                        eng d  a0163-386400aAntimycobacterial labdane diterpenes from leucas stelligera0 aAntimycobacterial labdane diterpenes from leucas stelligera  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcOCT  a1836-18410 v763 a<p>Phytochemical investigation of the acetone extract of the aerial parts of Leucas stelligera afforded four new compounds (1-4) belonging to the labdane diterpene series as well as two known flavones, velutin (5) and chrysoeriol (6). Structure elucidation of the new compounds was carried out using ID and 2D NMR spectroscopic data and single-crystal X-ray crystallography of compound 1. Compounds 1-4 exhibited selective antimycobacterial activity against Mycobacterium tuberculosis with IC50 values in the range 5.02-9.80 mu g/mL.</p>1 aKulkarni, Roshan, R.1 aShurpali, Ketaki1 aPuranik, Vedavati, G.1 aSarkar, Dhiman1 aJoshi, Swati, P.  uhttps://library.ncl.res.in/content/antimycobacterial-labdane-diterpenes-leucas-stelligera-002307nas a2200265   4500008004100000022001400041245018200055210006900237260008000306300001200386490000700398520125200405653001801657653002201675653003301697653002301730653002401753100002501777700002201802700002101824700002501845700002301870700002101893856012701914       2013                        eng d  a1612-475800aLavandula gibsoni and plectranthus mollis essential oils: chemical analysis and insect control activities against aedes aegypti, anopheles sfttephensi and culex quinquefasciatus0 aLavandula gibsoni and plectranthus mollis essential oils chemica  aTIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANYbSPRINGER HEIDELBERGcDEC  a713-7180 v863 a<p>Essential oils and acetone extracts from Lavandula gibsoni and Plectranthus mollis, family Lamiaceae, were investigated for their mosquito larvicidal activity against 4th instar larvae of Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus. LC50 values against these three species were 48.3, 62.8 and 54.7 mg/L for L. gibsoni essential oil and 118.5, 137.2 and 128.1 mg/L, respectively, for its acetone extract, while LC50 values for P. mollis essential oil were 25.4, 33.5 and 29.5 mg/L and 195.0, 213.8 and 209.0 mg/L, respectively, for its acetone extract. Repellence of the essential oils was assessed against A. aegypti adults. L. gibsoni essential oil provided 100 % protection for more than 7 h at a concentration of 2.0 mg/cm(2). Under the same conditions, the standard repellent N,N-diethyl-meta-toluamide, at 0.25 mg/cm(2), provided 100 % protection for more than 8 h, while P. mollis essential oil was only weakly repellent. The major components from both essential oils were identified based on GC-MS analysis and linear retention indices. Our results demonstrated promising larvicidal activities of both essential oils against these mosquito species. L. gibsoni essential oil also showed promising repellent activity.</p>10aEssential oil10aLavandula gibsoni10aMosquito larvicidal activity10aMosquito repellent10aPlectranthus mollis1 aKulkarni, Roshan, R.1 aPawar, Pushpa, V.1 aJoseph, Mary, P.1 aAkulwad, Ambadas, K.1 aSen, Avalokiteswar1 aJoshi, Swati, P.  uhttps://library.ncl.res.in/content/lavandula-gibsoni-and-plectranthus-mollis-essential-oils-chemical-analysis-and-insect-001508nas a2200217   4500008004100000022001400041245010100055210006900156260009200225300001400317490000700331520067800338653000601016653002201022653003401044653001401078653002201092100002501114700002101139856013001160       2013                        eng d  a1478-641900aNew 2,2-diphenylpropane and ethoxylated aromatic monoterpenes from Lavandula gibsoni (Lamiaceae)0 aNew 22diphenylpropane and ethoxylated aromatic monoterpenes from  a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcAUG  a1323-13290 v273 a<p>A new substituted 2,2-diphenylpropane (1) and two new ethoxylated aromatic monoterpene alcohols (2 and 4) have been isolated from the acetone extract of the aerial parts of Lavandula gibsoni, along with the known compounds 8-hydroxycarvacrol (3), 8-hydroxythymol (5), coumarin (6), 4-methylresorcinol (7), 7,4-dimethylapigenin (8), salvigenin (9), -sitosteryl-3-O–D-glucopyranosyl-6-O-palmitate (10) and euscaphic acid D (11). The structures of the isolated compounds were assigned on the basis of their H-1- and C-13-NMR spectra and two-dimensional NMR techniques, which included COSY, HSQC, HMBC and NOESY experiments and comparison with the reported literature.</p>10a210a2-diphenylpropane10aaromatic monoterpene alcohols10aLamiaceae10aLavandula gibsoni1 aKulkarni, Roshan, R.1 aJoshi, Swati, P.  uhttps://library.ncl.res.in/content/new-22-diphenylpropane-and-ethoxylated-aromatic-monoterpenes-lavandula-gibsoni-lamiaceae-001991nas a2200289   4500008004100000022001400041245008900055210006900144260009200213300001200305490000700317520096500324653002501289653001501314653002101329653002101350653002801371653001401399100002501413700002201438700002401460700003001484700001901514700002601533700002101559856012101580       2014                        eng d  a1478-641900aAntifungal dimeric chalcone derivative kamalachalcone E from Mallotus philippinensis0 aAntifungal dimeric chalcone derivative kamalachalcone E from Mal  a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcFEB  a245-2500 v283 a<p>From the red coloured extract (Kamala) prepared through acetone extraction of the fresh whole uncrushed fruits of Mallotus philippinensis, one new dimeric chalcone (1) along with three known compounds 1-(5,7-dihydroxy-2,2,6-trimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen -1-one (2), rottlerin (3) and 4 `-hydroxyrottlerin (4) were isolated. The structure of compound 1 was elucidated by 1D and 2D NMR analyses that included HSQC, HMBC, COSY and ROESY experiments along with the literature comparison. Compounds 1-4 were evaluated for antifungal activity against different human pathogenic yeasts and filamentous fungi. The antiproliferative activity of the compounds was evaluated against Thp-1 cell lines. Compounds 1 and 2 both exhibited IC50 of 8, 4 and 16 mu g/mL against Cryptococcus neoformans PRL518, C. neoformans ATCC32045 and Aspergillus fumigatus, respectively. Compound 4, at 100 mu g/mL, showed 54% growth inhibition of Thp-1 cell lines.</p>10a4 `-hydroxyrottlerin10aantifungal10adimeric chalcone10akamalachalcone E10aMallotus philippinensis10arottlerin1 aKulkarni, Roshan, R.1 aTupe, Santosh, G.1 aGample, Suvarna, P.1 aChandgude, Macchindra, G.1 aSarkar, Dhiman1 aDeshpande, Mukund, V.1 aJoshi, Swati, P.  uhttps://library.ncl.res.in/content/antifungal-dimeric-chalcone-derivative-kamalachalcone-e-mallotus-philippinensis-001851nas a2200193   4500008004100000245012800041210006900169260000800238300001200246490000600258520112400264100001901388700002901407700002501436700002401461700001901485700002101504856013201525       2015                        eng d00aRottlerin derivatives and other compounds from mallotus philippinensis fruits and their potential antimycobactrial activity0 aRottlerin derivatives and other compounds from mallotus philippi  cJUN  ae28-e300 v23 a<p>The methanolic extract of the fruits of Mallotus philippinensis afforded 13 compounds, 7,11-diketo-lanost-3-ol (1, as acetate), lanosta-8-ene-3β-ol (2, as acetate), pregnenolone (3, as acetate), trans-chalcone (4), kamalachalcone E (5), oleanolic acid (6), gallic acid (7), kaempferol (8), myricetin (9), 1-(5,7-dihydroxy-2,2,6-trimethyl-2 H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one (10), 4′-hydroxyisorottlerin (11), rottlerin (12), and shikimic acid (13). Compound 1 was isolated as a new natural product and its structure was elucidated by 1D and 2D nuclear magnetic resonance analyses including heteronuclear single quantum correlation, heteronuclear multiple-bond correlation, correlation spectroscopy, and nuclear Overhauser effect spectroscopy experiments. All of the isolated compounds were evaluated for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra. Compounds 11 and 12 exhibited promising inhibitory activity with IC50 values of 0.89 ± 0.33 µg/mL (MIC 2.06 ± 0.41 µg/mL) and 7.59 ± 0.42 µg/mL (MIC 11.56 ± 0.35 µg/mL), respectively.</p>1 aBhardwaj, Rima1 aChinchansure, Ashish, A.1 aKulkarni, Roshan, R.1 aArkile, Manisha, A.1 aSarkar, Dhiman1 aJoshi, Swati, P.  uhttps://library.ncl.res.in/content/rottlerin-derivatives-and-other-compounds-mallotus-philippinensis-fruits-and-their-potential01812nas a2200265   4500008004100000022001400041245009900055210006900154260009200223300001200315490000700327520083500334653002101169653003001190653003101220653001501251653001401266100002501280700002101305700002301326700002601349700001901375700002101394856013101415       2016                        eng d  a1478-641900aNew pimarane diterpenes and other antimycobacterial metabolites from anisochilus verticillatus0 aNew pimarane diterpenes and other antimycobacterial metabolites   a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcMAR  a675-6810 v303 a<p>Phytochemical investigation of the acetone extract of the aerial parts of Anisochilus verticillatus afforded a new 8,9-secopimarane diterpene (1), two new isopimarane diterpenes (2, 3) and the known ursolic acid (4), beta-amyrin (5), -amyrin (6), stigmast-5-en-3-one (7) and hydroxychavicol (8). Structures of the new compounds were elucidated with the help of 1D and 2D nuclear magnetic resonance spectroscopic data, and single crystal X-ray crystallography of compound 3. Compounds 2 and 8 inhibited Mycobacterium tuberculosis H37Ra with an IC50 of 11.3 (IC90 of 20.0g/mL) and 12.5g/mL, respectively. Correspondingly, molecular docking studies with Extra Precision Glide revealed a correlation between score and biological activity for these compounds to describe the molecular basis for the most significant SAR results.</p>10aalanine racemase10aAnisochilus verticillatus10aantimycobacterial activity10aditerpenes10aLamiaceae1 aKulkarni, Roshan, R.1 aShurpali, Ketaki1 aKhedkar, Vijay, M.1 aPuranik, Vedavati, G.1 aSarkar, Dhiman1 aJoshi, Swati, P.  uhttps://library.ncl.res.in/content/new-pimarane-diterpenes-and-other-antimycobacterial-metabolites-anisochilus-verticillatus-0