02219nas a2200193   4500008004100000022001400041245011400055210006900169260007100238300001600309490000700325520145100332100002001783700002001803700002101823700002701844700002201871856013201893       2011                        eng d  a0743-746300aSynthesis of poly-L-glutamic acid grafted silica nanoparticles and their assembly into macroporous structures0 aSynthesis of polyLglutamic acid grafted silica nanoparticles and  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcOCT  a12124-121330 v273 a<p>Polypeptide-coated silica nanoparticles represent an interesting class of organic inorganic hybrids since the ordered secondary structure of the polypeptide grafts imparts functional properties to these nanoparticles. The synthesis of a poly-L-glutamic acid (PLGA) silica nanoparticle hybrid by employing N-carboxyanhydride (NCA) polymerization to synthesize the polypeptide chains and Cu catalyzed azide alkyne cycloaddition reaction to graft these chains onto the silica surface is reported. This methodology enables the synthesis of well-defined polypeptide chains that are attached onto the silica surface at high surface densities. The PLGA-silica conjugate particles are well dispersed in water, and have been thoroughly characterized using multinuclear (C-13, Si-29) solid state NMR, thermogravimetric analysis, Fourier transform infrared, dynamic light scattering, and transmission electron microscopy. The pH-dependent reversible aggregation of the PLGA-silica particles, driven by the change in PLGA structure, has also been studied. Preliminary results on the use of aqueous dispersions of silica-PLGA for the preparation of three-dimensional macroporous structures with oriented pores by ice templating methodology are also demonstrated. These macroporous materials, comprising a biocompatible polymer shell covalently attached to rigid inorganic cores, adopts an interesting lamellar structure with fishbone-type architecture.</p>1 aKar, Mrityunjoy1 aPauline, Minois1 aSharma, Kamendra1 aKumaraswamy, Guruswamy1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/synthesis-poly-l-glutamic-acid-grafted-silica-nanoparticles-and-their-assembly-macroporous-0