00913nas a2200145   4500008004100000245015700041210006900198260000800267300001400275490000600289520030100295100002500596700002100621856012500642       2018                        eng d00aChiral amino-acid-amide based ionic liquids as a stereoselective organocatalyst in asymmetric transfer hydrogenation of acetophenone at room-temperature0 aChiral aminoacidamide based ionic liquids as a stereoselective o  cMAR  a2623-26250 v33 aChiral Ionic Liquids (CILs) of amino acid amide were synthesized and used as novel organo catalyst for Asymmetric Transfer Hydrogenation (ATH) of acetophenone at room temperature. The developed CILs show very high yield and excellent enantio-selectivity in transfer hydrogenation of acetophenone.1 aJavle, Balasaheb, R.1 aKinage, Anil, K.  uhttps://library.ncl.res.in/content/chiral-amino-acid-amide-based-ionic-liquids-stereoselective-organocatalyst-asymmetric01674nas a2200193   4500008004100000022001400041245019100055210006900246260000800315300001400323490000700337520088200344100002301226700003001249700002801279700002901307700002101336856012301357       2025                        eng d  a1477-052000aConjugate addition/cyclization of propanal with isatylidene malononitriles: an efficient one-pot organocatalytic approach for the synthesis of 3′-methyl spiro[2H-pyran-3,4′-indoline]0 aConjugate additioncyclization of propanal with isatylidene malon  cJUN  a6214-62190 v233 a<p>
	The organocatalyzed one-pot Michael addition reaction of propanal to isatylidene malononitriles remains largely unexplored due to challenges in controlling the reaction and preventing side processes such as aldol condensation, self-aldolization, and 1,3-dipolar cycloaddition. In this study, we introduce a one-pot methodology for the synthesis of 3 `-alkyl spiro[2H-pyran-3,4 `-indoline] via an organocatalyzed Michael addition of simple propanal to isatylidene malononitrile derivatives, which are generated in situ from isatin derivatives and malononitrile. Subsequent reduction of the Michael adduct with NaBH4 leads to the target product with high efficiency under mild conditions. This strategy offers several advantages, including environmental sustainability, high to excellent yields, shorter reaction times, cost-effectiveness, and ease of implementation.</p>
1 aPatil, Baliram, R.1 aNichinde, Chandrakant, B.1 aGirase, Amardipsing, S.1 aChaudhari, Suryakant, S.1 aKinage, Anil, K.  uhttps://library.ncl.res.in/content/conjugate-additioncyclization-propanal-isatylidene-malononitriles-efficient-one-pot