01174nas a2200241 4500008004100000022001400041245012200055210006900177260006100246300001200307490000800319520032100327653001900648653001000667653001800677653001000695653002900705653001000734100002300744700002100767700001700788856012700805 2008 eng d a1011-372X00aHighly chemoselective catalytic system for hydrogenation of diketones to ketols: an environmentally benevolent system0 aHighly chemoselective catalytic system for hydrogenation of dike a233 SPRING STREET, NEW YORK, NY 10013 USAbSPRINGERcJAN a257-2600 v1203 a

Ru(Phen)(2)Cl-2 [Phen = Phenanthroline] anchored in organo-functionalized MCM-41 [Ru(Phen)(2)Cl-NH-MCM-41] efficiently catalyzes highly chemoselective hydrogenation of diketones to ketols (Sel. similar to 99%) under environmentally benign tri-phasic (solid-liquid-liquid) reaction condition in aqueous medium.

10aChemoselective10adione10aHydrogenation10aketol10aruthenium phenanthroline10aWater1 aDeshmukh, Amit, A.1 aKinage, Anil, K.1 aKumar, Rajiv uhttps://library.ncl.res.in/content/highly-chemoselective-catalytic-system-hydrogenation-diketones-ketols-environmentally-002512nas a2200229 4500008004100000022001400041245015100055210006900206260007300275300001400348490000600362520159700368653002101965653003301986653002402019653001102043100002102054700002102075700002602096700002902122856013102151 2008 eng d a1566-736700aHighly selective synthesis of mono-ethylene glycol phenyl ethers via hydroxyalkoxylation of phenols by cyclic carbonates using large pore zeolites0 aHighly selective synthesis of monoethylene glycol phenyl ethers  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAPR a1649-16550 v93 a

Hydroxyalkoxylation of phenols by cyclic carbonates catalyzed by alkali loaded large pore zeolites has been reported. The study shows that KL type zeolite was recyclable and selective in producing mono-ethylene glycol pheryl ethers in similar to 98.5% yield. Various substituted simple phenols were converted into mono-ethylene glycol ether of phenols with over 90% yields, except 3-bromo and 2-methyl phenols. Mono hydroxyl plienols such as hydroquinone, biphenol and BPA (2,2-bis(4-hydroxyphenyl)propane) also produce corresponding mono- and di-ethylene glycol ethers. The ratio of ethylene carbonate to phenol was found to be critical for selective formation of monoethylene glycol phenyl ether of phenols. A ratio of two results in formation of appreciable amount of diether derivative viz., 2-(2-phenoxyethoxy) ethanol. Compared to ethylene carbonate, a lower reactivity of 1,2-propane carbonate was found for hydroxyalkoxylation of phenol. It was found that ring opening at less hindered methylene carbon of 1,2-propylene carbonate prevailed giving rise to selective formation of beta-hydroxy phenyl ethers. The reactivity of ethylene carbonate towards O-alkylation versus transesterification of phenol has been explained on the basis of HSAB concept. Finally, it has been shown that yield of mono-ethylene glycol phenyl ether is controlled both by basicity and channel architecture of zeolite structure. KL zeolite was found to be the most effective zeolite because of it's intermediate basicity and one dimensional channel architect. (C) 2008 Elsevier B.V. All rights reserved.

10acyclic carbonate10aethylene glycol phenyl ether10ahydroxyalkoxylation10aphenol1 aKinage, Anil, K.1 aGupte, Sunil, P.1 aChaturvedi, Rajiv, K.1 aChaudhari, Raghunath, V. uhttps://library.ncl.res.in/content/highly-selective-synthesis-mono-ethylene-glycol-phenyl-ethers-hydroxyalkoxylation-phenols-002025nas a2200241 4500008004100000022001400041245011900055210006900174260010600243300001400349490000700363520106900370653002401439653003401463653003301497653002501530653001401555100002301569700002101592700001701613700002201630856013101652 2010 eng d a0277-538700aEfficient heterogeneous catalytic system for chemoselective hydrogenation of unsaturated ketones in aqueous medium0 aEfficient heterogeneous catalytic system for chemoselective hydr aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV a3262-32680 v293 a

A highly chemoselective and green heterogeneous catalytic system of immobilized Ru(II)-phenanthroline complexes on amino functionalised MCM-41 material for the chemoselective hydrogenation of unsaturated ketones to unsaturated alcohols is demonstrated using water as a solvent The XRD and FTIR spectra show the highly ordered hexagonal nature of the MCM-41 even after encapsulation of the ruthenium complex The complex retains its configuration after anchoring as was confirmed by FTIR and UV-Vis analysis The detailed reaction parametric effect was studied for the hydrogenation of 3 methylpent-3-en-2-one to achieve complete conversion up to >99% chemoselectivity of 3-methylpent-3-en-2 ol The anchored heterogeneous catalysts were recycled effectively and reused five times with marginal changes in activity and selectivity The use of water as a solvent not only afforded high activity for the hydroge nation reaction compared to organic solvents but also afforded a green process Crown Copyright (C) 2010 Published by Elsevier Ltd All rights reserved

10a1 10 Phenanthroline10aalpha beta Unsaturated ketone10aChemoselective hydrogenation10amesoporous materials10aruthenium1 aDeshmukh, Amit, A.1 aKinage, Anil, K.1 aKumar, Rajiv1 aMeijboom, Reinout uhttps://library.ncl.res.in/content/efficient-heterogeneous-catalytic-system-chemoselective-hydrogenation-unsaturated-ketones-002066nas a2200277 4500008004100000022001400041245012400055210006900179260007300248300001200321490000800333520109900341653002601440653001801466653001901484653001301503653001801516653001901534653001401553653001001567100002301577700002101600700001701621700002201638856012801660 2010 eng d a1381-116900aHeterogenized Ru(II) phenanthroline complex for chemoselective hydrogenation of diketones under biphasic aqueous medium0 aHeterogenized RuII phenanthroline complex for chemoselective hyd aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcDEC a114-1200 v3333 a

The chemoselective hydrogenation of acetylacetone to 4-hydroxypentan-2-one over immobilized ruthenium phenanthroline metal complexes in amino functionalized MCM-41 in biphasic aqueous reaction medium was investigated. The catalyst was characterized by XRD, TEM, surface analysis, FT-IR and UV-vis to understand the morphology, complex geometry, and XPS such that the oxidation state of the metal complex inside the MCM-41 framework could be understood. The use of water as a solvent, not only gives high activity and selectivity for hydrogenation of acetylacetone, but also gives a path for an environmentally safer process. The optimizations of ligand, metal to ligand ratio, the choice of solvent and other reaction parameters were studied in detail. The heterogeneous catalytic system gave a higher degree of chemoselectivity (99%) towards 4-hydroxypentan-2-one as compared to homogeneous catalyst when hydrogenation was carried out using water as a solvent. The immobilized ruthenium-phenanthroline complex was easily separated and reused. (C) 2010 Elsevier B.V. All rights reserved.

10a4-Hydroxypentan-2-one10aacetylacetone10aChemoselective10aDiketone10aHydrogenation10aPhenanthroline10aruthenium10aWater1 aDeshmukh, Amit, A.1 aKinage, Anil, K.1 aKumar, Rajiv1 aMeijboom, Reinout uhttps://library.ncl.res.in/content/heterogenized-ruii-phenanthroline-complex-chemoselective-hydrogenation-diketones-under-001503nas a2200193 4500008004100000022001400041245011300055210006900168260007100237300001600308490000700324520074800331100002301079700002201102700002101124700001701145700002201162856012501184 2010 eng d a0888-588500aRu(II) phenanthroline complex as catalyst for chemoselective hydrogenation of nitro-aryls in a green process0 aRuII phenanthroline complex as catalyst for chemoselective hydro a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcDEC a12180-121840 v493 a

Ru(II) Phenanthroline [Ru(II)(Phen)(n) where n = 1,2,3] complexes were used as highly chemoselective catalysts for hydrogenation of nitro aryls using molecular hydrogen in an aqueous media. Water, universal solvent, was used as a reaction mixture for hydrogenation of nitro-aryls to make the process green. The chemoselectivity in hydrogenation of substituted nitrobenzene to substituted aniline was obtained as high as >99% at about complete conversion of substituted nitrobenzene. The parametric effects, including effect of solvent, effect of ligand, effect of metal to ligand ratio, effect of temperature and pressure, were studied in detail to obtain the best results. The Ru(Phen)(n) was characterized by FTIR, UV-vis, and XPS.

1 aDeshmukh, Amit, A.1 aPrashar, Atul, K.1 aKinage, Anil, K.1 aKumar, Rajiv1 aMeijboom, Reinout uhttps://library.ncl.res.in/content/ruii-phenanthroline-complex-catalyst-chemoselective-hydrogenation-nitro-aryls-green-001780nas a2200229 4500008004100000022001400041245011700055210006900172260007900241300001400320490000700334520086600341653002701207653003801234653003101272653003101303100002101334700002201355700002001377700002601397856012701423 2011 eng d a1044-580300aGrowth of hydrothermally stable meso-porous silica structure interconnected around micro-porous zeolite crystals0 aGrowth of hydrothermally stable mesoporous silica structure inte a360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USAbELSEVIER SCIENCE INCcDEC a1166-11720 v623 a

The growth of hydrothermally stable ordered meso-porous silica with M41S type structure interconnected around zeolite crystals was achieved from seeds normally nucleating the crystallization of micro-porous zeolite. The solid state NMR and FT-IR showed species like Si(OSi)(3)OH and Si(OSi)(2)(OH)(2) (or Q(3) and Q(2) sites, respectively) are formed during first hydrothermal treatment with surfactant and NaOH. These species and surface silanol group of zeolite crystal condense to give meso-porous silica structure interconnected around zeolite crystal during re-crystallization at lower pH. Resulting meso-micro-porous hybrid material is found to be highly active, selective and stable in the synthesis of 2-(phenylamino) ethanol from aniline and ethylene carbonate compare to parent ZSM-5 and pure MCM-41. (C) 2011 Elsevier Inc. All rights reserved.

10aHydrothermal stability10aInterconnected meso-porous silica10aMeso-micro hybrid material10aSynthesis of amino alcohol1 aKinage, Anil, K.1 aPrashar, Atul, K.1 aBerlier, Gloria1 aChaturvedi, Rajiv, K. uhttps://library.ncl.res.in/content/growth-hydrothermally-stable-meso-porous-silica-structure-interconnected-around-micro-001897nas a2200241 4500008004100000022001400041245011900055210006900174260009200243300001000335490000600345520098600351653002501337653002301362653002401385653001501409653001201424100002201436700002101458700002501479700002101504856013001525 2012 eng d a1751-825300aEnvironmentally benign synthesis of beta-hydroxy sulfides using cyclic carbonates catalyzed by large-pore zeolites0 aEnvironmentally benign synthesis of betahydroxy sulfides using c a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcAUG a19-260 v53 a

An efficient one-pot synthesis of beta-hydroxy sulfides from thiophenol and cyclic carbonates catalyzed by large-pore zeolites has been reported. Reaction of thiophenol with ethylene carbonate in the presence of the Na-X zeolite catalyst gave the highest yield of 2-(phenylthio)ethanol (100%), while reaction with propylene carbonate a highest yield of regioselective product 1-(phenylthio)propan-2-ol was obtained (97%). Enantiomerically pure 1,2-propylene carbonate gave highly regioselective and stereospecific phenylthiopropanol, demonstrating that original chirality of propylene carbonate is retained. A plausible mechanism has been proposed for zeolite-catalyzed transformation involving a chemoselective nucleophilic attack of thiophenoloxide ion onto the less-substituted carbon of cyclic carbonate. The Na-X zeolite catalyst is recyclable and provides advantages of green chemistry approach to the synthesis of beta-hydroxy sulfides without the use of any solvent.

10abeta-hydroxy sulfide10aethylene carbonate10apropylene carbonate10athiophenol10azeolite1 aUpare, Pravin, P.1 aKinage, Anil, K.1 aShingote, Savita, K.1 aGupte, Sunil, P. uhttps://library.ncl.res.in/content/environmentally-benign-synthesis-beta-hydroxy-sulfides-using-cyclic-carbonates-catalyzed-000913nas a2200145 4500008004100000245015700041210006900198260000800267300001400275490000600289520030100295100002500596700002100621856012500642 2018 eng d00aChiral amino-acid-amide based ionic liquids as a stereoselective organocatalyst in asymmetric transfer hydrogenation of acetophenone at room-temperature0 aChiral aminoacidamide based ionic liquids as a stereoselective o cMAR a2623-26250 v33 aChiral Ionic Liquids (CILs) of amino acid amide were synthesized and used as novel organo catalyst for Asymmetric Transfer Hydrogenation (ATH) of acetophenone at room temperature. The developed CILs show very high yield and excellent enantio-selectivity in transfer hydrogenation of acetophenone.1 aJavle, Balasaheb, R.1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/chiral-amino-acid-amide-based-ionic-liquids-stereoselective-organocatalyst-asymmetric01562nas a2200253 4500008004100000022001400041245013400055210006900189260000800258300001400266490000800280520068000288653001800968653002100986653001801007653001701025653002901042653001701071100002401088700002501112700002401137700002101161856012601182 2019 eng d a1011-372X00aAmino acid amide based ionic liquid as an efficient organo-catalyst for solvent-free knoevenagel condensation at room temperature0 aAmino acid amide based ionic liquid as an efficient organocataly cSEP a2368-23750 v1493 a

Ionic liquids of amino acid amide were synthesized and used as an efficient catalyst for solvent-free Knoevenagel condensation. Synthesized ionic liquids are an environmentally benign, inexpensive, metal free and plays the dual role of solvent as well as an efficient catalyst for Knoevenagel condensation. A wide range of aliphatic, aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. Additionally, the catalyst is easily separable and recyclable without loss of activity. [GRAPHICS] .

10aAcrylonitrile10aAmino acid amide10aCyanoacrylate10aIonic liquid10aKnoevenagel condensation10aSolvent-free1 aBurate, Pralhad, A.1 aJavle, Balasaheb, R.1 aDesale, Pranjal, H.1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/amino-acid-amide-based-ionic-liquid-efficient-organo-catalyst-solvent-free-knoevenagel01565nas a2200193 4500008004100000245016700041210007100208260000800279300001600287490000700303520077100310100003001081700002301111700002901134700002401163700002401187700002101211856013901232 2023 eng d00aOrganocatalysed one-pot three component synthesis of 3,3′-disubstituted oxindoles featuring an all-carbon quaternary center and [spiro 2H-pyran-3,4′-indoline]0 aOrganocatalysed onepot three component synthesis of 33′disubstit cAPR a13206-132120 v133 a

A simple and efficient methodology for the one-pot synthesis of 3,3 `-disubstituted oxindoles featuring an all-carbon quaternary center has been demonstrated through l-proline catalysed three-component reaction based on sequential Knoevenagel condensation/Michael addition and also one-pot synthesis of spiro[2H-pyran-3,4 `-indoline] through consecutive Knoevenagel condensation/Michael addition/reduction/cyclization reactions from readily available isatin derivatives, malononitrile, and ketones. The present methodology presents several advantages, including simple reaction set-up, short reaction times, and easy to work-up. Also, this strategy offers broad substrate scope with excellent yields and high atom economy, under mild reaction conditions.

1 aNichinde, Chandrakant, B.1 aPatil, Baliram, R.1 aChaudhari, Suryakant, S.1 aMali, Bhupendra, P.1 aGonnade, Rajesh, G.1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/organocatalysed-one-pot-three-component-synthesis-33%E2%80%B2-disubstituted-oxindoles-featuring-all01810nas a2200205 4500008004100000022001400041245012800055210006900183260000800252300001400260490000700274520103600281100002901317700003001346700002301376700002801399700002601427700002101453856013001474 2024 eng d a1477-052000aBase controlled rongalite-mediated reductive aldol/cyclization and dimerization of isatylidene malononitriles/cyanoacetates0 aBase controlled rongalitemediated reductive aldolcyclization and cFEB a1727-17320 v223 a

In this study, we developed a novel methodology involving a base-controlled, rongalite-mediated reductive/aldol reaction, followed by cyclization of isatylidene malononitriles/cyanoacetates, resulting in the synthesis of spiro[2,3-dihydrofuran-3,3 `-oxindole]. Additionally, we have disclosed a rongalite-mediated dimerization process for isatylidene malononitriles, yielding dispiro[cyclopent-3 `-ene]bisoxindole. The utilization of rongalite in this reaction serves a dual purpose, acting both as a reducing agent and a C1 synthon. The developed approach has several advantages like a simple reaction setup, a wide substrate scope, requiring less time, using water as a green solvent, no metal or catalyst is required and products can be easily isolated via filtration with excellent yields under mild reaction conditions. A novel methodology was developed for the synthesis of spiro[2,3-dihydrofuran-3,3 `-oxindole] and dispiro[cyclopent-3 `-ene]bisoxindole under mild reaction conditions using inexpensive reagents.

1 aChaudhari, Suryakant, S.1 aNichinde, Chandrakant, B.1 aPatil, Baliram, R.1 aGirase, Amardipsing, S.1 aKrishna, Gamidi, Rama1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/base-controlled-rongalite-mediated-reductive-aldolcyclization-and-dimerization-isatylidene01410nas a2200181 4500008004100000245015700041210007100198260000800269300001400277490000700291520066600298100002300964700003000987700002901017700002601046700002101072856013501093 2024 eng d00aOrganocatalyzed [4+2] cycloaddition of α,β-unsaturated ketones and isatylidene malononitrile: accessing spiro[3-arylcyclohexanone]oxindole derivatives0 aOrganocatalyzed 42 cycloaddition of αβunsaturated ketones and is cJAN a2873-28770 v143 a

Herein, we developed a series of compounds featuring spiro[3-arylcyclohexanone]oxindoles through Barbas [4 + 2] cycloaddition reactions between isatylidene malononitrile and alpha,beta-unsaturated ketones using l-proline as an organocatalyst. The reported methodology offers many advantages such as mild reaction conditions, diverse substrate scope with high yields, easy reaction setup, and use of easily synthesizable starting materials. An l-proline catalyzed-Barbas-[4 + 2]-cycloaddition reaction is reported for the synthesis of spiro[3-arylcyclohexanone]oxindole derivatives. The method can tolerate a diverse substrate scope with high yields.

1 aPatil, Baliram, R.1 aNichinde, Chandrakant, B.1 aChaudhari, Suryakant, S.1 aKrishna, Gamidi, Rama1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/organocatalyzed-42-cycloaddition-%CE%B1%CE%B2-unsaturated-ketones-and-isatylidene-malononitrile02098nas a2200241 4500008004100000022001400041245012000055210006900175260000800244300001200252490000700264520120300271653002901474653002001503653004301523653004701566653003301613653000901646100002601655700002101681700002901702856012501731 2024 eng d a0360-319900aReaction kinetics for catalytic hydrogenation of quinoline to decahydroquinoline as liquid organic hydrogen carrier0 aReaction kinetics for catalytic hydrogenation of quinoline to de cNOV a102-1120 v923 a

The catalytic hydrogenation of quinoline to decahydroquinoline (DHQ) formation is studied for various parameters such as temperature, hydrogen pressure, reaction time, solvents, reactant-to-solvent ratio, and catalyst loading over 5%Pd loaded on alumina (Pd/Al2O3) to obtain optimal reaction conditions. The hydrogen uptake of quinoline in the liquid phase reaction using isopropylalcohol (IPA) is studied in an autoclave reactor. The optimum reaction parameters of 50 bar H2 pressure and 175oC with reactant to solvent ratio of 1:9 for reaction time of 5 h are observed. The effect of IPA solvent showed that hydrogen uptake of 6.91 wt% with complete hydrogenation of quinoline and DHQ yield of more than 99% is observed. The reaction kinetic model is developed for a simplified reaction mechanism and is simulated using the Markov Chain Monte Carlo (MCMC) simulation tool to predict the rate constants and the experimental observations are validated with the model predictions. The activation energy for quinoline hydrogenation to py-THQ formation is estimated to be 136.57 kJ/mol. It is envisaged that quinoline hydrogenation to pz-THQ is the rate-limiting step in the DHQ formation.

10aDecahydroquinoline (DHQ)10aHydrogen uptake10aLiquid organic hydrogen carrier (LOHC)10aMarkov chain Monte Carlo (MCMC) simulation10aThermal screening unit (TSU)10atool1 aBagwan, Farahanaz, M.1 aKinage, Anil, K.1 aVasireddy, Satyam, Naidu uhttps://library.ncl.res.in/content/reaction-kinetics-catalytic-hydrogenation-quinoline-decahydroquinoline-liquid-organic01674nas a2200193 4500008004100000022001400041245019100055210006900246260000800315300001400323490000700337520088200344100002301226700003001249700002801279700002901307700002101336856012301357 2025 eng d a1477-052000aConjugate addition/cyclization of propanal with isatylidene malononitriles: an efficient one-pot organocatalytic approach for the synthesis of 3′-methyl spiro[2H-pyran-3,4′-indoline]0 aConjugate additioncyclization of propanal with isatylidene malon cJUN a6214-62190 v233 a

The organocatalyzed one-pot Michael addition reaction of propanal to isatylidene malononitriles remains largely unexplored due to challenges in controlling the reaction and preventing side processes such as aldol condensation, self-aldolization, and 1,3-dipolar cycloaddition. In this study, we introduce a one-pot methodology for the synthesis of 3 `-alkyl spiro[2H-pyran-3,4 `-indoline] via an organocatalyzed Michael addition of simple propanal to isatylidene malononitrile derivatives, which are generated in situ from isatin derivatives and malononitrile. Subsequent reduction of the Michael adduct with NaBH4 leads to the target product with high efficiency under mild conditions. This strategy offers several advantages, including environmental sustainability, high to excellent yields, shorter reaction times, cost-effectiveness, and ease of implementation.

1 aPatil, Baliram, R.1 aNichinde, Chandrakant, B.1 aGirase, Amardipsing, S.1 aChaudhari, Suryakant, S.1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/conjugate-additioncyclization-propanal-isatylidene-malononitriles-efficient-one-pot01901nas a2200265 4500008004100000022001400041245014500055210007200200260000800272300001500280490000700295520084600302653003301148653004301181653004701224653002201271653004001293653002901333100002901362700003001391700002301421700002801444700002101472856014201493 2025 eng d a2365-654900aEfficient synthesis of 3,3′-Spirooxindole γ-Butyrolactone via Rongalite-mediated domino reductive aldol and spiro-lactonization reactions0 aEfficient synthesis of 33′Spirooxindole γButyrolactone via Ronga cFEB ae2024059960 v103 a

In this study, we develop a novel methodology involving rongalite-mediated domino reductive/aldol reaction, followed by spiro-lactonization of 2-oxoindolin-3-ylidene acetates/malonates in presence of base to synthesis of 3,3 `-spirooxindole gamma-butyrolactone. The detail study, such as effect of solvent, effect of different base and substrate has been carried out. Scale up of this methodology is also done. Sodium hydroxymethanesulfinate dihydrate (rongalite) concurrently has a dual role in this context; it acts as a reducing agent as well as C1 synthon. This approach offers several advantages, such as being metal- and catalyst-free, involving a simple reaction protocol, having a wide substrate scope, using water as a green solvent, and providing good to excellent yields of the products under mild reaction conditions.

10a(+/-) Coixspirolactam A & [310a3 `-spirooxindole gamma-butyrolactone]10aDomino reductive/aldol/spiro-lactonization10aGood step economy10aRongalite as reductant & C1 synthon10aWater as a green solvent1 aChaudhari, Suryakant, S.1 aNichinde, Chandrakant, B.1 aPatil, Baliram, R.1 aGirase, Amardipsing, S.1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/efficient-synthesis-33%E2%80%B2-spirooxindole-%CE%B3-butyrolactone-rongalite-mediated-domino-reductive02758nas a2200145 4500008004100000245015200041210006900193260000800262490000700270520213700277100002102414700002102435700002902456856012702485 2025 eng d00aEvaluation of reaction kinetics for chemoselective hydrogenation of citral for intensification of citral intermediates using copper-based catalysts0 aEvaluation of reaction kinetics for chemoselective hydrogenation cMAR0 v673 a

Citral intermediates’ formation kinetics is studied using non-noble metal catalyst (Cu/SiO2) to evaluate catalyst performance characteristics via chemoselective hydrogenation of citral. The catalyst is synthesised by the precipitation method and characterised using XRD, FESEM and BET surface area analyser. Hydrogenation experiments are carried out using an Autoclave reactor in the temperature range of 80–120°C, pressure range of 10–50 bar and for catalyst loadings of 0.5, 1 and 1.5 g. The intermediates product distribution comprises aldehyde and alcohol formation such as citronellal, nerol and citronellol formation. The performance of the Cu/SiO2 catalyst is evaluated using the parameters such as citral conversion, citronellol selectivity and yield as 96.96%, 95.30% and 92.30%, respectively under optimal conditions of 50 bar, 120°C and 1 g catalyst for the reaction time of 100 min. The absence of internal and external mass transfer limitations is verified using the Carberry number and Weisz-Prater modulus criterion. The intrinsic kinetics of the gas–liquid phase hydrogenation of citral is determined using the Langmuir–Hinshelwood-Hougen-Watson (LHHW) model for citral intermediates formation. The reaction kinetic parameters show that citronellol formation favours by the nerol route compared to citronellal conversion.

1 aDebtirtha, Banik1 aKinage, Anil, K.1 aVasireddy, Satyam, Naidu uhttps://library.ncl.res.in/content/evaluation-reaction-kinetics-chemoselective-hydrogenation-citral-intensification-citral01595nas a2200205 4500008004100000022001400041245012900055210006900184260000800253300001400261490000700275520082600282100002901108700003001137700002301167700002801190700002501218700002101243856012501264 2025 eng d a1477-052000aRongalite-promoted self-dimerization of 3-acylidene-2-oxindoles: a diastereoselective route to synthesis of bispirooxindoles0 aRongalitepromoted selfdimerization of 3acylidene2oxindoles a dia cOCT a8687-86940 v233 a

A facile and efficient one-pot rongalite-mediated self-dimerization of 3-acylidene-2-oxindoles has been developed for the diastereoselective synthesis of highly functionalized dispirocyclopentanebisoxindoles. The reaction proceeds via a domino sequence involving intermolecular Michael addition followed by intramolecular aldol cyclization under basic conditions. Rongalite, an inexpensive and readily available reagent (similar to\$0.03 per g), plays a crucial role in promoting the transformation, offering significant advantages such as operational simplicity, step economy, scalability to gram-scale synthesis, and potential for post-functionalization. This methodology provides an efficient route to structurally complex oxindole frameworks with high stereocontrol, demonstrating broad synthetic utility.

1 aChaudhari, Suryakant, S.1 aNichinde, Chandrakant, B.1 aPatil, Baliram, R.1 aGirase, Amardipsing, S.1 aKaulage, Sandeep, H.1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/rongalite-promoted-self-dimerization-3-acylidene-2-oxindoles-diastereoselective-route01906nas a2200277 4500008004100000022001400041245017200055210006900227260000800296490000700304520082900311653003601140653004501176653002501221653002001246653005401266100003001320700001701350700002801367700002301395700002901418700002601447700001801473700002101491856011601512 2025 eng d a1434-193X00aSequential nitro-michael addition and reductive cyclization cascade reaction for diastereoselective synthesis of multifunctionalized 3,3′-pyrrolidinyl-spirooxindoles0 aSequential nitromichael addition and reductive cyclization casca cFEB0 v283 a

In this investigation, we elucidated, one-pot two stage efficient synthesis of multifuctionalized spiro[oxindole -3,3 `-pyrrolidine]. The methodology proceeds via organocatalyzed nitro-Michael addition reaction between indolylidenecyanoesters and nitroalkanes to formed nitro-Michael adduct which transformed into multifunctionalized 3,3 `-pyrrolidinyl-spirooxindoles by metal catalyzed reductive cyclization cascade. DFT investigations were conducted to elucidate the mechanism underlying the preferential reduction of the nitro group, with subsequent attack on the nitrile and ester groups remain inert throughout the reaction process. The approach is operationally simple, easily scalable, exhibits compatibility with readily accessible starting material and catalysts, thereby emphasizing cost-effectiveness.

10a3 `-pyrrolidinyl spirooxindoles10aDFT study for regioselective cyclization10aDiastereoselective 310aorganocatalysis10aPd/C catalysed partial reductive spirocyclization1 aNichinde, Chandrakant, B.1 aBhati, Meema1 aGirase, Amardipsing, S.1 aPatil, Baliram, R.1 aChaudhari, Suryakant, S.1 aGamidi, Rama, Krishna1 aJoshi, Kavita1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/sequential-nitro-michael-addition-and-reductive-cyclization-cascade-reaction01883nas a2200253 4500008004100000022001400041245010100055210006900156260000800225300001100233490000700244520100500251653002901256653003001285653002001315653002301335653002201358653002701380100002601407700002401433700002101457700002901478856012201507 2026 eng d a0930-751600aReaction kinetics for dehydrogenation of decahydroquinoline to quinoline for hydrogen generation0 aReaction kinetics for dehydrogenation of decahydroquinoline to q cFEB ae701770 v493 a

Catalytic dehydrogenation of decahydroquinoline (DHQ) to quinoline is a promising pathway for hydrogen release in liquid organic hydrogen carrier systems. In this work, solvent-free DHQ dehydrogenation over Pd/Al2O3 is systematically investigated to evaluate hydrogen release performance and reaction kinetics. High DHQ conversion (83.9%) and degree of dehydrogenation (82.7%) are achieved at optimal reaction conditions. A power-law kinetic model based on a simplified reaction mechanism is developed and simulated using a Markov Chain Monte Carlo (MCMC) approach for estimation of rate constants and validation of concentration profiles with experimental data. The apparent activation energies are determined to be 45.85 kJ/mol for DHQ to 5,6,7,8-tetrahydroquinoline (bz-THQ) and 185.43 kJ/mol for bz-THQ to quinoline formation, identifying latter as the rate-limiting step. This framework provides mechanistic insight and supports the potential of DHQ as an efficient hydrogen carrier.

10aDecahydroquinoline (DHQ)10adegree of dehydrogenation10aDehydrogenation10arate-limiting step10aReaction kinetics10aWeisz-Prater criterion1 aBagwan, Farahanaz, M.1 aDadkar, Sarthak, S.1 aKinage, Anil, K.1 aVasireddy, Satyam, Naidu uhttps://library.ncl.res.in/content/reaction-kinetics-dehydrogenation-decahydroquinoline-quinoline-hydrogen-generation01460nas a2200181 4500008004100000245010600041210006900147260000900216300001400225490000700239520077400246100002301020700003001043700002801073700002901101700002101130856012701151 2026 eng d00aThiophenol-mediated metal-free chemoselective conjugate reduction strategy for 3-alkylidene oxindoles0 aThiophenolmediated metalfree chemoselective conjugate reduction  cFEB  a7702-77060 v163 a

A mild and metal-free thiophenol-mediated chemoselective conjugate reduction of 3-alkylidene oxindoles via a thiol-ene-type Michael addition was effectively carried out. Thiophenol as an efficient reductant is used in DMSO, and the transformation proceeds without the need for metal catalyst, external hydrogen source, or harsh reagents. The reaction displays a broad substrate scope, accommodating both electron-donating and electron-withdrawing substituents, and delivers 3-alkyloxindoles in high yields with excellent beta-selectivity. This sustainable and operationally simple method unveils a distinct thiol-mediated reduction mechanism, providing a green and versatile approach for accessing reduced oxindole derivatives and related Michael acceptors.

1 aPatil, Baliram, R.1 aNichinde, Chandrakant, B.1 aGirase, Amardipsing, S.1 aChaudhari, Suryakant, S.1 aKinage, Anil, K. uhttps://library.ncl.res.in/content/thiophenol-mediated-metal-free-chemoselective-conjugate-reduction-strategy-3-alkylidene