02225nas a2200241   4500008004100000022001400041245009500055210006900150260010000219300001200319490000700331520133700338653001501675653001901690653002601709653002401735100002701759700001801786700002501804700001701829700001901846856011801865       2011                        eng d  a0254-870400aActive pharmaceutical ingredient (api) from an estuarine fungus, microdochium nivale (Fr.)0 aActive pharmaceutical ingredient api from an estuarine fungus mi  aC/O KIRAN DALELA, 1/206 VIKAS NAGAR, KURSI RD, LUCKNOW 226 022, INDIAbTRIVENI ENTERPRISEScSEP  a653-6580 v323 a<p>Various marine habitats sustain variety of bio-sources of ecological and biotech potentials. Pharmaceutical potential compound Cyclosporine A was reported from marine fungus Microdochium nivale associated with Porteresia coarctata, a marine salt marsh grass from mangrove environment distributed along the Central West Coast (CWC) of India. This study involves association of M. nivale with P. coarctata plant, fermentation conditions, purification of Cyclosporine A, chemical characterization etc. Its antifungal inhibition and MIC (Minimum inhibitory concentration) against Aspergillus strains (A. niger, A. japonicus, A. fresenii), yeasts and dermatophytes (Candida sp., Cryptococcus neoformans, Trichophyton mentagrophytes, T tonsurans, T violaceum, Microsporium gypsum and Fusarium sp.) were evaluated. However, the MIC against A. japonicus, C. neoformans, Candida sp. and T. tonsurans were confirmed to be as low as 12.5-25 mg disc(-1). The antifungal properties of Cyclosporine A against Aspergillus species, yeast and dermatophytes revealed that Cyclosporine A would be a potential compound for life threatening diseases caused by above fungi in both human and animals. Furthermore, we have reported herewith another source of Cyclosporin A derived from filamentous fungus, M. nivale. occurring in marine environment.</p>10aantifungal10aCyclosporine A10aEstuarine environment10aMicrodochium nivale1 aBhosale, Siddharth, H.1 aPatil, K., B.1 aParameswaran, P., S.1 aNaik, C., G.1 aJagtap, T., G.  uhttps://library.ncl.res.in/content/active-pharmaceutical-ingredient-api-estuarine-fungus-microdochium-nivale-fr-0