02221nas a2200157   4500008004100000022001400041245014900055210006900204260011000273300001600383490000600399520148800405100002901893700002201922856011901944       2014                        eng d  a2046-206900aSelective synthesis of propofol (2,6-diisopropylphenol), an intravenous anesthetic drug, by isopropylation of phenol over H-beta and H-mordenite0 aSelective synthesis of propofol 26diisopropylphenol an intraveno  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUL  a32467-324740 v43 a<p>Propofol (2,6-diisopropylphenol/DIPP) is the world's most widely used intravenous general anesthetic and is typically synthesized by isopropylation of phenol over an acid catalyst. It is highly difficult to stabilize bio-oil containing phenolic compounds. The isopropylation of this phenol (a model compound representing species in bio-oils) is one of the options to stabilize the bio-oil and convert it into valuable products. Probably for the first time, H-beta- and H-mordenite-catalysed vapour phase isopropylation of phenol with isopropyl alcohol (IPA) was studied to selectively synthesize DIPP. The optimization of various operating parameters such as molar ratio (phenol : IPA), weight hourly space velocity (WHSV), reaction temperature and time on stream were performed. H-beta (94% phenol conv. and 56% DIPP sel.) was found to be a potential and more active catalyst than H-mordenite (68% phenol conv. and 43% DIPP sel.) at optimized process parameters. A kinetic model is proposed to probe the intricate reaction kinetics and validated (R-2 &gt; 0.98) by the experimental results. H-beta catalyst was observed to be stable for more than 25 h with 94% phenol conversion and 56% selectivity towards DIPP at optimized process parameters. The phenol conversion and DIPP selectivity obtained in the present study are higher than those reported so far. The activation energy obtained for isopropylation of phenol with IPA over H-beta is calculated to be 25.39 kJ mol(-1).</p>1 aNandiwale, Kakasaheb, Y.1 aBokade, Vijay, V.  uhttps://library.ncl.res.in/content/selective-synthesis-propofol-26-diisopropylphenol-intravenous-anesthetic-drug-001387nas a2200229   4500008004100000022001400041245012200055210006900177260000800246300001200254490000700266520058600273653001300859653001400872653002000886653002900906653001600935100002900951700002400980700002201004856013101026       2015                        eng d  a1863-065000aSynthesis of non-toxic triethyl citrate plasticizer by esterification of renewable citric acid using modified zeolite0 aSynthesis of nontoxic triethyl citrate plasticizer by esterifica  cJUN  a927-9310 v433 a<p>Triethyl citrate (TEC), a non-toxic plasticizer, was synthesized by esterification of renewable citric acid (CA, from entire waste of oranges) with ethanol over modified H-ZSM-5 (HZ-5) zeolite. Different micro-meso composites (M-HZ-5) with varying crystallinities were prepared by alkaline treatment of HZ-5. M-HZ-5(0.6) (87% crystallinity) was observed to be a potential and environmentally benign catalyst with 96% CA conversion, 64% TEC selectivity (61.44% TEC yield), and a reusability of six cycles. The probable catalytic mechanism of esterification was also proposed.</p>10aBiowaste10aCatalysts10agreen chemistry10aMicro-mesopre composites10areusability1 aNandiwale, Kakasaheb, Y.1 aBorikar, Sanjay, P.1 aBokade, Vijay, V.  uhttps://library.ncl.res.in/content/synthesis-non-toxic-triethyl-citrate-plasticizer-esterification-renewable-citric-acid-using