01669nas a2200193   4500008004100000022001400041245006700055210006700122260009900189300001200288490000700300520098400307653001701291653001901308653001101327100002001338700001901358856009801377       2012                        eng d  a0144-861700aRecent applications of starch derivatives in nanodrug delivery0 aRecent applications of starch derivatives in nanodrug delivery  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcJAN  a987-9940 v873 a<p>Starch has found use in industries as diverse as food, textiles, cosmetics, plastics, adhesives, paper, and pharmaceuticals. From a pharmaceutical standpoint, starch finds its value in solid-oral dosage forms, where it has been used as a binder, diluent, and disintegrant. However, only recently has the use of starch in nanotechnology started to make significant advances in biomedical applications, including newer drug delivery techniques. There has been a considerable effort to develop biodegradable nanoparticles as effective drug delivery systems. Being cheap, non-toxic, renewable, biodegradable and compatible with many other materials for industrial applications, starch is attracting the interest of drug delivery scientists. We have put together in a short and concise format, recent applications of starch derivatives in the emerging field of nanodrug delivery with the conclusion that a lot still needs to be done. (C) 2011 Elsevier Ltd. All rights reserved.</p>10aApplications10ananotechnology10aStarch1 aRodrigues, Asha1 aEmeje, Martins  uhttps://library.ncl.res.in/content/recent-applications-starch-derivatives-nanodrug-delivery-002207nas a2200229   4500008004100000022001400041245020100055210006900256260005700325300001400382490000800396520130300404653001201707653002001719653002601739653001301765100001901778700001901797700001701816700001901833856012501852       2014                        eng d  a0932-011300aAntiplasmodial activity-aided isolation and identification of quercetin-4 `-methyl ether in chromolaena odorata leaf fraction with high activity against chloroquine-resistant plasmodium falciparum0 aAntiplasmodial activityaided isolation and identification of que  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcDEC  a4415-44220 v1133 a<p>The present study was undertaken to evaluate the antiplasmodial activity of Chromolaena odorata leaf extract and gradient fractions through in vivo and in vitro tests, aimed at identifying its antiplasmodial constituents. Sub-fractions obtained from the most active gradient fraction were further tested for cytotoxicity against THP-1 cells, chloroquine-sensitive (HB3) and chloroquine-resistant (FCM29) Plasmodium falciparum. Our results showed the dichloromethane gradient fraction was most effective, significantly (P&lt;0.05) suppressing infection by 99.46 % at 100 mg/kg body weight. Amongst its 13 sub-fractions (DF1-DF13), DF11 was highly active, with IC50 of 4.8 and 6.74 mu g/ml against P. falciparum HB3 and FCM29, respectively. Cytotoxicity of DF11 was estimated to be above 50 mu g/ml, and its separation by column chromatography yielded a flavonoid which was characterized as 3, 5, 7, 3' tetrahydroxy-4'-methoxyflavone from its spectroscopic data. It significantly suppressed infection (65.43-81.48 %) in mice at 2.5-5 mg/kg doses and compared favourably with the effects of chloroquine and artemisinin. It may therefore serve as a useful phytochemical and antiplasmodial activity marker of C. odorata leaves, which exhibit potential for development as medicine against malaria.</p>10amalaria10aMedicinal plant10aPlasmodium falciparum10aToxicity1 aEzenyi, I., C.1 aSalawu, O., A.1 aKulkarni, R.1 aEmeje, Martins  uhttps://library.ncl.res.in/content/antiplasmodial-activity-aided-isolation-and-identification-quercetin-4-methyl-ether-0