01689nas a2200277   4500008004100000022001400041245010500055210006900160260007700229300001200306490000700318520072700325653001201052653002501064653001301089653001501102653001401117100002401131700002701155700002301182700001601205700001801221700002301239700001801262856013101280       2012                        eng d  a1439-422700aAntagonism of microRNA function in zebrafish embryos by using locked nucleic acid enzymes (LNAzymes)0 aAntagonism of microRNA function in zebrafish embryos by using lo  aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcMAR  a584-5890 v133 a<p>MicroRNAs (miRNAs) have crucial functions in many cellular processes, such as differentiation, proliferation and apoptosis; aberrant expression of miRNAs has been linked to human diseases, including cancer. Tools that allow specific and efficient knockdown of miRNAs would be of immense importance for exploring miRNA function. Zebrafish serves as an excellent vertebrate model system to understand the functions of miRNAs involved in a variety of biological processes. We designed and employed a strategy based on locked nucleic acid enzymes (LNAzymes) for in vivo knockdown of miRNA in zebrafish embryos. We demonstrate that LNAzyme can efficiently knockdown miRNAs with minimal toxicity to the zebrafish embryos.</p>10aenzymes10alocked nucleic acids10amicroRNA10amorpholino10azebrafish1 aSuryawanshi, Hemant1 aLalwani, Mukesh, Kumar1 aRamasamy, Soundhar1 aRana, Rajiv1 aScaria, Vinod1 aSivasubbu, Sridhar1 aMaiti, Souvik  uhttps://library.ncl.res.in/content/antagonism-microrna-function-zebrafish-embryos-using-locked-nucleic-acid-enzymes-lnazymes-000987nas a2200265   4500008004100000022001400041245013600055210006900191260007600260300001400336490000700350653001400357653001900371653002000390653001500410653000800425100001800433700003100451700002400482700002100506700002500527700002300552700001800575856012800593       2012                        eng d  a1433-785100aTuberculosis drug streptomycin as a potential cancer therapeutic: inhibition of miR-21 function by directly targeting its precursor0 aTuberculosis drug streptomycin as a potential cancer therapeutic  aCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAbWILEY-BLACKWELLcDEC  a1019-10230 v5110aApoptosis10adrug discovery10aGene expression10ainhibitors10aRNA1 aBose, Debojit1 aJayaraj, Gopal, Gunanathan1 aSuryawanshi, Hemant1 aAgarwala, Prachi1 aPore, Subrata, Kumar1 aBanerjee, Rajkumar1 aMaiti, Souvik  uhttps://library.ncl.res.in/content/tuberculosis-drug-streptomycin-potential-cancer-therapeutic-inhibition-mir-21-function-0